New organocobaloximes with biphenylglyoxime ligands: Synthesis, spectroscopic and structural characterization

Erdem-Tuncmen, Mukadder; Karipçin, Fatma

doi:10.3233/mgc-140124

Cited by 4 publications

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“…5 Afterwards, large numbers of copper(II) complexes and other metal complexes, particularly of the first row transition metals, have been synthesized, characterized, and evaluated for their nuclease mimicking and anticancer activities. [6][7][8] The two modes of binding with DNA residues have been identified, i.e., intercalating and covalent binding.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, structure characterization, DNA binding, and cleavage properties of mononuclear and tetranuclear cluster of copper(II) complexes

Vafazadeh

Willis²,

Heidari³

et al. 2015

ACSi

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Two copper(II) complexes, cluster 1, and mononuclear 2, have been synthesized by reacting acetylacetone and benzohydrazide (1:1 ratio for 1 and 1:2 ratio for 2) with CuCl 2 in a methanol solution. In 2, which is a new complex, the ligand acts as a tetradentate which binds the metal ion via two amide-O atoms and two imine-N atoms providing an N 2 O 2 square-planar around the copper(II) ion. The absorption spectra data evidence strongly suggested that the two copper(II) compounds could interact with CT-DNA (intrinsic binding constant, K b = 0.45 × 10 4 M-1 for 1 and K b = 2.39 × 10 4 M-1 for 2). The super coiled plasmid pBR322 DNA cleavage ability was studied with 1 and 2 in the presence and absence of H 2 O 2 as an oxidant. In both the absence and the presence of an oxidizing agent, complex 2 exhibited no nuclease activity. However, even in the absence of an oxidant, complex 1 exhibited significant DNA cleavage activity.

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Section: Introductionmentioning

confidence: 99%

Synthesis, structure characterization, DNA binding, and cleavage properties of mononuclear and tetranuclear cluster of copper(II) complexes

Vafazadeh

Willis²,

Heidari³

et al. 2015

ACSi

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“…4‐(Napthyl‐1‐amino)biphenylglyoxime was prepared in accordance with previous report . A solution containing napthyl‐1‐amine (2 mmol, 0.315 g) and triethylamine (2.2 mmol, 309 µL) in methanol (10 mL) was added dropwise to a suspension of 4‐biphenylchloroglyoxime (2 mmol, 0.55 g) in methanol (50 mL) over 15 min.…”

Section: Methodsmentioning

confidence: 99%

Synthesis and Characterization of Novel Organocobaloximes as Potential Catecholase and Antimicrobial Activity Agents

Erdem-Tuncmen

Karipçin

Sarıboğa

2013

Archiv der Pharmazie

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An asymmetric, potentially bidentate dioxime ligand (H₂L) was formed by condensation of 4-biphenylchloroglyoxime and napthyl-1-amine. Two equivalents of H₂L were reacted with CoCl₂ · 6H₂O under appropriate conditions with deprotonation of the dioxime ligand. A series of new organocobaloxime derivatives of the type [CoR(HL)₂Py], [CoRL₂PyB₂F₄], and [CoRL₂Py(Cu(phen))₂] (H₂L = 4-(napthyl-1-amino)biphenylglyoxime; phen = 1,10-phenathroline; R = izopropyl and benzyl; Py = pyridine) were synthesized. The products were characterized by elemental analysis, molar conductance, FT-IR, ¹H NMR, and magnetic susceptibility measurements. Catecholase-like activity properties of all complexes were also studied. All complexes are catalysts for the oxidation of 3,5-di-tert-butylcatechol to 3,5-di-tert-butyl-1,2-benzoquinone in methanol. Antimicrobial activity studies of H₂L and the six complexes were carried out on standard strains (human pathogenic) of bacteria (Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), Bacillus cereus, Enterococcus faecalis, Streptococcus pneumoniae, Listeria monocytogenes, Bacillus subtilis, Escherichia coli, Pseudominas aeruginosa, Salmonella typhi) and the yeast Candida albicans. The compounds showed a significant inhibition of the growth of the Gram-positive bacteria tested. Among the tested microorganisms, S. aureus was the most sensitive strain, especially to H₂L and its complexes.

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“…1B curve c), revealing that Cu-N bonds formed between Cu 2+ and nitrogen of ATP and MB. 29 It could be conjectured that the thiol of ATP was placed in an appropriate location aer the Cu-N bonds formed so that the chromophore and auxochromous groups of MB could be reduced completely. Thus, it could be proposed that the special complex was formed as shown in Fig.…”

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A simple and novel system for colorimetric detection of cobalt ions

Liu

Jia

Bian

et al. 2014

Analyst

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New organocobaloximes with biphenylglyoxime ligands: Synthesis, spectroscopic and structural characterization

Cited by 4 publications

References 0 publications

Synthesis, structure characterization, DNA binding, and cleavage properties of mononuclear and tetranuclear cluster of copper(II) complexes

Synthesis, structure characterization, DNA binding, and cleavage properties of mononuclear and tetranuclear cluster of copper(II) complexes

Synthesis and Characterization of Novel Organocobaloximes as Potential Catecholase and Antimicrobial Activity Agents

A simple and novel system for colorimetric detection of cobalt ions

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