Laser holographic interferometry is the newest method to measure the mass diffusion coefficient and has been widely used in recent years. The processing of interference fringe images is a critical step of getting the final precise experimental results. On the basis of Fourier transformation and phase measurements, a new method of processing Mach-Zehnder interference fringes is introduced in this article. By experimental verification and uncertainty analysis, the accuracy of this method is validated. Mass diffusion coefficients of ethylene glycol dimethyl ether and diethylene glycol dimethyl ether, two new fuel additives in air were measured with the method introduced in this study.