New Opportunities for Diagnosis and Prognosis of Stroke: The Benefits of Across Border Approaches

Abstract

Ischemic stroke is a leading cause of disability, with its treatment not yet optimal. It is thus mandatory to make preclinical research on this topic more efficient. This review summarizes current development of research aimed to improve diagnosis and prognosis of ischemic stroke. For more details, see our recent review published in Lancet Neurology.

In vivo whole brain microvascular imaging in mice using transcranial 3D Ultrasound Localization Microscopy

“…Alterations of the morphology and/or function of this cerebral vascular network are common features of neurological disorders such as stroke, aneurysms, vascular cognitive impairment, neurodegenerative diseases. 1 , 2 , 3 , 4 , 5 Non-invasive high-resolution imaging of the cerebral vascular morphology and function is therefore key for the study of these pathologies. Imaging the vascular networks in the whole brain remains however challenging in vivo , as it spans multiple spatial scales (from micron-sized capillaries to millimeter-sized vessels) and multiple scales of velocity (detection from ∼1 mm/s in capillaries to ∼100 mm/s in larger vessels).…”