New-onset versus chronic atrial fibrillation in acute myocardial infarction: differences in short- and long-term follow-up

Maagh, Petra; Butz, Thomas; Wickenbrock, Ingo; Prull, M.W.; Plehn, Gunnar; Trappe, Hans‐Joachim; Meißner, Axel

doi:10.1007/s00392-010-0227-6

Cited by 20 publications

(27 citation statements)

References 32 publications

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“…The most common type of AF in this study was new-onset AF accounting for almost half of the AF population followed by paroxysmal and chronic AF. Other, smaller studies have reported previous AF to be more common than new-onset AF during MI 6 14. AF in this study was also more common in patients with NSTEMI than in patients with STEMI.…”

Section: Discussioncontrasting

confidence: 41%

All types of atrial fibrillation in the setting of myocardial infarction are associated with impaired outcome

Batra

Svennblad

Held

et al. 2016

Heart

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Section: Discussioncontrasting

confidence: 41%

All types of atrial fibrillation in the setting of myocardial infarction are associated with impaired outcome

Batra

Svennblad

Held

et al. 2016

Heart

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“…All of these factors lead to a decrease in cardiac output and an increase in left ventricular filling pressure [ 17 ]. Patients with pre-existing AF generally have greater cardiovascular disease burden and more co-morbidities than those without AF owing to AF being present for longer [ 18 , 19 ]. In contrast, patients with new-onset AF were relatively younger and had fewer co-morbidities than patients with pre-existing AF [ 4 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…Results from previous studies evaluating the prognostic significance of pre-existing and new-onset AF in patients with ACS are conflicting [ 8 – 11 , 18 , 21 ]. In a prospective multicenter study of 3393 patients with ACS, pre-existing AF was associated with a significantly higher risk of mortality (HR 1.4, 95% CI 1.01–1.99) than no AF, while new-onset AF was not [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Adverse Outcomes Associated with Pre-Existing and New-Onset Atrial Fibrillation in Patients with Acute Coronary Syndrome: A Retrospective Cohort Study

et al. 2019

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Introduction Atrial fibrillation (AF) often occurs in patients with acute coronary syndrome (ACS). It remains unclear whether pre-existing or new-onset AF confers different risk in patients with ACS. Methods We conducted a retrospective cohort study using Taiwan’s National Health Insurance Research Database. Patients who were hospitalized with a primary diagnosis of ACS from 2005 to 2009 were studied. Major outcomes were mortality, heart failure, and combined ischemic stroke/systemic embolism (IS/SE). The date of the first ACS diagnosis was defined as the index date. Pre-existing AF was defined as AF occurring before the index date. New-onset AF was defined as AF that started after or at the same time as the ACS diagnosis. Results Among 6663 patients with ACS, 488 (7.3%) had pre-existing AF and 479 (7.2%) had new-onset AF. Compared to patients with pre-existing AF, those with new-onset AF were younger, less likely to have co-morbidities, and more likely to receive evidence-based therapy. The un-adjusted risks of adverse outcomes in both groups were similar. Compared to pre-existing AF, new-onset AF was significantly associated with a higher adjusted risk of death (hazard ratio 1.27, 95% confidence interval 1.06–1.52) and IS/SE (hazard ratio 1.49, 95% confidence interval 1.01–2.20). The significant associations between new-onset AF and adverse outcomes were more likely to be observed in elderly patients with ACS. Conclusions New-onset AF during ACS was associated with a significantly increased risk of adverse outcomes, especially in the elderly patients.

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“…Previous evidence indicated that among patients with acute myocardial infarction, those with chronic AF had a higher in-hospital mortality rate than those with newly diagnosed AF or no AF. 12 Therefore, we carried out a systematic review and meta-analysis to investigate the effect of AF on clinical outcomes in patients with IS undergoing thrombolysis.…”

Section: Introductionmentioning

confidence: 99%

Atrial Fibrillation is Associated With Poor Outcomes in Thrombolyzed Patients With Acute Ischemic Stroke

Yue¹,

et al. 2016

Medicine

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The influence of atrial fibrillation (AF) on the clinical outcomes of patients with ischemic stroke (IS) has not been completely determined. We aimed to perform a systematic review and meta-analysis to assess the relationship between AF and adverse events in patients with acute IS treated with thrombolysis.PubMed, EMBASE, and the Cochrane Library were searched for relevant studies regarding the association between AF and the outcomes of patients with IS treated with thrombolysis. Random and fixed effect models were used for pooling data.Twelve cohort studies involving 14,801 patients with acute IS were included. Meta-analysis revealed that patients with AF were more likely to die within 90 days after thrombolysis (odds ratio [OR], 2.13; 95% confidence interval [CI]: 1.68–2.70, P < 0.001), whereas this association was not observed in hospitalized patients (OR, 1.50; 95% CI, 0.86–2.60; P = 0.150). AF was associated with a reduced incidence of favorable outcomes (modified Rankin Scale ≤ 2) (OR, 1.95; 95% CI: 1.33–2.85, P = 0.001) and an increased risk of symptomatic intracerebral hemorrhage (OR, 1.28; 95% CI: 1.08–1.52, P = 0.006). No evident publication bias was found by Begg's test or Egger's test.Comorbidity of AF may increase the risk of adverse outcomes for patients with IS undergoing thrombolysis. Further well-designed trials are warranted to confirm this association.

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New-onset versus chronic atrial fibrillation in acute myocardial infarction: differences in short- and long-term follow-up

Cited by 20 publications

References 32 publications

All types of atrial fibrillation in the setting of myocardial infarction are associated with impaired outcome

All types of atrial fibrillation in the setting of myocardial infarction are associated with impaired outcome

Adverse Outcomes Associated with Pre-Existing and New-Onset Atrial Fibrillation in Patients with Acute Coronary Syndrome: A Retrospective Cohort Study

Atrial Fibrillation is Associated With Poor Outcomes in Thrombolyzed Patients With Acute Ischemic Stroke

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