New Onset Severe Anemia and Fulminant Idiopathic Intracranial Hypertension

Waisberg, Ethan; Yu, Caberry W.; Micieli, Jonathan A

doi:10.1017/cjn.2021.203

Cited by 10 publications

(10 citation statements)

References 5 publications

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“…Waisberg, et al 22 reported on five consecutive cases of fulminant IIH and new onset severe anemia (Hb<80g/L). This case series concluded that a CBC should be performed on all new cases of papilledema since severe anemia is temporally associated with fulminant IIH cases and that the treatment of anemia can be enough to normalize the ICP.…”

Section: Introductionmentioning

confidence: 99%

Anemia and Spaceflight Associated Neuro-Ocular Syndrome (SANS)

Waisberg

Ong

Masalkhi

et al. 2023

Prehosp. Disaster med.

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Spaceflight associated neuro-ocular syndrome (SANS) is a collection of distinct findings seen in some astronauts following prolonged spaceflight and is characterized by: optic disc edema, globe flattening, and choroidal folds. In this manuscript, we describe the potential mechanisms linking anemia and SANS. Future research aimed at understanding the relationship between these conditions may help to develop countermeasures and mitigation efforts for SANS.

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Section: Introductionmentioning

confidence: 99%

Anemia and Spaceflight Associated Neuro-Ocular Syndrome (SANS)

Waisberg

Ong

Masalkhi

et al. 2023

Prehosp. Disaster med.

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“…For example, the recently-drawn link between idiopathic intracranial hypertension and anemia can possibly be explained by theories based on human physiology, such as anemic hypoxia. 4,5 The altered human physiology in space provides many interesting learning points for medical students. These interesting learning points also provide practical examples of human physiology which may lead to a better understanding of these concepts by medical students.…”

Section: Introductionmentioning

confidence: 99%

“…For example, the recently-drawn link between idiopathic intracranial hypertension and anemia can possibly be explained by theories based on human physiology, such as anemic hypoxia. 4,5…”

Section: Introductionmentioning

confidence: 99%

Space Medicine: The Next Frontier of Medical Education

Waisberg

Ong

Masalkhi

et al. 2023

Prehosp. Disaster med.

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Spaceflight has always been met with awe by the general public and may also have strong implications for medical training for future physicians, regardless of specialty or practice. Within the near future, the commercialization of spaceflight will lead to an unprecedented surge in travelers to space. With this increase, the understanding of space medicine and potential physiological risks of microgravity will only become more important for doctors to understand. Historically, teaching education on how the body responds to various different environments and environmental changes has been a longstanding core to medical education. Thus, education about the physiological, pathologic, and histologic changes to weightlessness over prolonged periods of time will likely provide additional insights to space medicine, as well as how medicine can be practiced here on Earth. The addition of space medicine to the medical curriculum will likely not only benefit future space medicine physicians, but also likely benefit all physicians and human health on Earth. In this manuscript, we discuss the various risks that astronauts undergo, as well as current space medicine education initiatives on Earth.

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“…Previous studies have documented IIH developing in the context of new or chronic anemia diagnoses (4,5). Several large prevalence studies have examined the association between anemia and IIH.…”

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confidence: 99%

Anemia and Idiopathic Intracranial Hypertension: A Case–Control Study

Yu¹,

Margolin²,

Micieli³

2022

Journal of Neuro-Ophthalmology

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Background:Idiopathic intracranial hypertension (IIH) is a condition that mostly affects obese women of childbearing age but has been reported to be temporally related to new diagnoses of anemia. Despite these reports, the association between anemia and IIH remains controversial. The present study aimed to understand the strength of association between anemia and IIH through a case–control design.Methods:Consecutive IIH patients were recruited from neuro-ophthalmology clinics and matched by age and sex to consecutive patients attending neuro-ophthalmology clinics with diagnoses other than IIH. Complete blood counts (CBCs) were reviewed within 6 months of neuro-ophthalmology presentation, and anemia was diagnosed by hemoglobin of <120 g/L in women and <130 g/L in men. Anemia was classified as microcytic (mean corpuscular volume (MCV) < 80 fL), normocytic (MCV 80-100 fL), and macrocytic (MCV > 100 fL) as well as mild (hemoglobin >110 g/L), moderate (hemoglobin 80–109 g/L), and severe (hemoglobin <80 g/L).Results:One hundred twenty-three IIH patients and 113 controls were included in the study. More IIH patients than controls had anemia (22.8%, 28/123 vs 10.6%, 12/113, P = 0.01) with an odds ratio of 2.48 (95% CI: 1.19, 5.16). There were no differences in severity of anemia or MCV between IIH patients and controls, with anemia most often being mild (57.1%, 16/28 vs 75%, 9/12) and normocytic (50.0%, 14/28 vs 50.0%, 6/12). However, 17.9% (5/28) of IIH patients had severe anemia compared with zero in the control group. IIH patients had a higher mean platelet count than controls (P < 0.001), and there were no differences on leukocyte counts.Conclusion:Idiopathic intracranial hypertension patients have a higher prevalence of anemia compared with non-IIH neuro-ophthalmology patients. The anemia was mostly mild and may be explained by other factors related to worse health status and obesity, including low socioeconomic status, poor nutrition, and polycystic ovary syndrome. However, as a CBC is a widely available test and anemia may influence the IIH disease course, we propose that this test be obtained in all patients with new papilledema.

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New Onset Severe Anemia and Fulminant Idiopathic Intracranial Hypertension

Cited by 10 publications

References 5 publications

Anemia and Spaceflight Associated Neuro-Ocular Syndrome (SANS)

Anemia and Spaceflight Associated Neuro-Ocular Syndrome (SANS)

Space Medicine: The Next Frontier of Medical Education

Anemia and Idiopathic Intracranial Hypertension: A Case–Control Study

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