New-Onset Postoperative Atrial Fibrillation After Isolated Coronary Artery Bypass Graft Surgery and Long-Term Survival

Filardo, Giovanni; Hamilton, Cody; Hebeler, Robert F.; Hamman, Baron L.; Grayburn, Paul A.

doi:10.1161/circoutcomes.108.816843

Cited by 115 publications

(78 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Even when using this comprehensive adjustment, POAF remained a significant and independent predictor of longterm mortality. The results of our study, supported by the results of other well-conducted studies in the field of coronary surgery, 1,5,8,11 provide strong evidence for a significant impact of POAF on long-term survival.…”

Section: Impact Of Poaf On Operative Mortalitysupporting

confidence: 87%

See 1 more Smart Citation

Statins Reduce Short‐ and Long‐Term Mortality Associated With Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting: Impact of Postoperative Atrial Fibrillation and Statin Therapy on Survival

Girerd¹,

Daleau²,

Voisine

et al. 2012

Clinical Cardiology

View full text Add to dashboard Cite

Background:Postoperative atrial fibrillation (POAF) is a frequent complication of coronary artery bypass grafting (CABG) surgery. The objective of this study was to determine the impact of POAF on both short‐ and long‐term mortality following isolated CABG.Hypothesis:POAF is associated with a poorer short and long‐term mortality following CABG.Methods:We retrospectively analyzed the preoperative and operative data of 6728 consecutive patients undergoing a first isolated CABG.Results:The incidence of POAF was 27.8%. Operative mortality was higher in patients with POAF compared to those without POAF (2.3% vs 0.9%, P < 0.001). On multivariate analysis, POAF remained an independent predictor of operative mortality (odds ratio [OR]: 1.78, P = 0.01). Patients with POAF also had reduced long‐term survival (6‐year survival: 85.3% vs 89.2%, P < 0.001). After adjusting for other predictors of mortality, POAF was significantly associated with increased long‐term mortality (hazard ratio [HR]: 1.35, P = 0.04). Of note, after adjustment for potential confounders, statin treatment had a highly protective effect in POAF patients for both operative mortality (OR: 0.38, P = 0.003) and long‐term mortality (HR: 0.62, P = 0.03), whereas it had no significant effect in patients without POAF.Conclusions:POAF is an independent predictor of both short‐ and long‐term mortality following CABG. Moreover, statin therapy was independently associated with better survival in patients with POAF.Dr. Pibarot holds the Canada Research Chair in Valvular Heart Diseases, Canadian Institutes of Health Research. Dr. Mathieu is a research scholar from the Fonds de Recherches en Santé du Québec, Montreal, Canada. Dr. Després has served as a speaker for Abbott Laboratories, AstraZeneca, Solvay Pharma, GlaxoSmithKline, and Pfizer Canada Inc.; has received research funding from Eli Lilly Canada; and has served on the advisory boards of Novartis, Theratechnologies, Torrent Pharmaceuticals Ltd., and Sanofi‐Aventis. The authors have no other funding, financial relationships, or conflicts of interest to disclose.

show abstract

Section: Impact Of Poaf On Operative Mortalitysupporting

confidence: 87%

“…Although POAF appears to be a benign complication in the majority of patients, the present study and other recent studies 1,5,8,12 have pinpointed that POAF is a strong and independent predictor of both operative and late mortality. Patients who develop POAF should be considered at higher risk for adverse outcomes in the short and long term.…”

Section: Discussionsupporting

confidence: 50%

Statins Reduce Short‐ and Long‐Term Mortality Associated With Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting: Impact of Postoperative Atrial Fibrillation and Statin Therapy on Survival

Girerd¹,

Daleau²,

Voisine

et al. 2012

Clinical Cardiology

View full text Add to dashboard Cite

show abstract

“…The development of AF is extremely common after cardiac surgery and is associated with longer intensive care unit and hospital stays, increased morbidity and mortality, and higher utilisation of healthcare resources [6][7][8][9][10][11]. For these reasons, it is of utmost importance to identify patients who are at risk for the development of postoperative AF (POAF), and to take due precautions in the preoperative period.…”

Section: Introductionmentioning

confidence: 99%

Usefulness of HATCH score as a predictor of atrial fibrillation after coronary artery bypass graft

et al. 2016

View full text Add to dashboard Cite

A b s t r a c tBackground: Atrial fibrillation (AF) after coronary artery bypass graft (CABG) surgery is associated with increased morbidity and mortality. The HATCH score was originally devised to predict the progression of paroxysmal AF to persistent AF. Aim:To determine whether the HATCH score predicts the development of AF after CABG surgery. Methods:The medical records of 284 consecutive patients, who underwent CABG surgery between January 2013 and December 2014, were retrospectively reviewed for the development of AF in the postoperative (POAF) period. The HATCH score, and clinical and echocardiographic parameters were evaluated for all patients.Results: Seventy (25%) patients developed POAF. The HATCH scores were higher in the POAF group (2.8 ± 1.8 vs. 1.1 ± 1.2, p < 0.001). The area of the HATCH score under the curve in the receiver operating characteristics analysis was 773 (95% CI 706-841, p < 0.001). When the HATCH score was 2 or more as a threshold, there was for POAF 72% sensitivity and 75% specificity. Conclusions:The results of the present study suggest that the HATCH score can be used to predict the development of POAF.

show abstract

“…SVEC progressing to AF was further characterised by a small prospective study by Wallmann et al, who reported that patients with more frequent SVEC's were at higher risk of developing AF (OR of 9.3, p = 0.01) than those with less frequent supraventricular ectopy. 7 Left atrial size was also significantly larger in the group developing AF compared to those remaining in sinus rhythm.…”

Section: Journal Of Atrial Fibrillation Journal Reviewmentioning

confidence: 91%

Supraventricular Ectopic Activity: When Excessive it is not all Benign!

Thomas¹,

Nguyen²

2010

J.A.F.I.B

View full text Add to dashboard Cite

Stroke is a significant cause of mortality and disabling morbidity. The major subtypes of stroke are divided into thrombo-embolic, haemorrhagic and cryptogenic, with each having different predisposing risk factors and management strategies. Atrial fibrillation (AF) is the commonest arrhythmia predisposing to thrombo-embolic stroke. The incidence of AF increases with age, affecting up to 5% in the elderly population. Electrophysiology studies have implicated that spontaneous atrial ectopic beats that originate in or near pulmonary veins adjacent to the left atrium, may initiate paroxysms of AF

show abstract

New-Onset Postoperative Atrial Fibrillation After Isolated Coronary Artery Bypass Graft Surgery and Long-Term Survival

Cited by 115 publications

References 31 publications

Statins Reduce Short‐ and Long‐Term Mortality Associated With Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting: Impact of Postoperative Atrial Fibrillation and Statin Therapy on Survival

Statins Reduce Short‐ and Long‐Term Mortality Associated With Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting: Impact of Postoperative Atrial Fibrillation and Statin Therapy on Survival

Usefulness of HATCH score as a predictor of atrial fibrillation after coronary artery bypass graft

Supraventricular Ectopic Activity: When Excessive it is not all Benign!

Contact Info

Product

Resources

About