“…Potential mechanism related to chronic tacrolimus use and imbalance immunological function in liver themselves, have been hypothesized base on the reports in LT children both in retrospective, prospective, case-controlled, and in vitro studies. 6,9,11,12,26,27 Chronic exposure to oral tacrolimus, the calcineurin inhibitor, might skew the Th2 response and alter gastrointestinal barrier, and eventually increases a risk of FA development due to the improper allergen exposure. 28 However, the present study showed that outgrowing of de novo FA patients did not related to a change in immunosuppressive protocol.…”