New onset of diabetes after transplantation — An overview of epidemiology, mechanism of development and diagnosis

Kesiraju, Sailaja; Paritala, Purna; Rao, Uma Maheswara; Sahariah, S

doi:10.1016/j.trim.2013.10.006

Cited by 54 publications

(43 citation statements)

References 85 publications

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“…Although the blood glucose level was maintained below 150 mg/dL, diabetes potentiates immunosuppression and increases the possibility of any infection [10].…”

Section: Discussionmentioning

confidence: 99%

Asymptomatic Mycotic Aneurysm of Ascending Aorta After Heart Transplantation: A Case Report

Behzadnia

Ahmadi

Mandegar

et al. 2015

Transplantation Proceedings

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“…Although the blood glucose level was maintained below 150 mg/dL, diabetes potentiates immunosuppression and increases the possibility of any infection [10].…”

Section: Discussionmentioning

confidence: 99%

Asymptomatic Mycotic Aneurysm of Ascending Aorta After Heart Transplantation: A Case Report

Behzadnia

Ahmadi

Mandegar

et al. 2015

Transplantation Proceedings

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“…Bu nedenlen NODAT'ın bildirilen prevalansı, %2 ile %53 arasında geniş değişkenlik göstermektedir (5,6). Kasiske ve ark.…”

Section: Prevalans Ve İnsidansunclassified

New-Onset Diabetes After Renal Transplantation

Bozkurt¹

2015

Turk Neph Dial Transpl

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ÖZBöbrek nakli sonrası gelişen diyabet (new-onset diabetes mellitus after transplantation, NODAT) böbrek alıcılarında yaygın olarak görülmektedir. NODAT, mikrovasküler ve kardiyovasküler hastalıklara yatkınlık kazandarak, hem greft sağkalımı azaltmakta hem de mortaliteyi artırmaktadır. Var olan ya da nakil sonrasında ortaya çıkan birçok risk faktörü ile kullanılan immünosüpresifler NODAT oluşumuyla ilişkilidir. Farklı sınıflandırma sistemleri ve tanımlamalardan dolayı böbrek nakli sonrası gelişen NODAT'ın gerçek insidansını belirlemek zordur. NODAT ve NODAT ile ilişkili faktörlerin iyi bilinmesi, yüksek riskli hastaların ayırt edilmesinde ve önleme/tedavi yaklaşımlarının belirlenmesinde klinisyenler için büyük önem taşımaktadır. NODAT riski, önleyici tedbirler alınarak ve immünosüpresif kullanımının iyi planlaması ile azaltılabilmektedir. Tanı sonrası NODAT'a yönelik özel antihiperglisemik tedavinin uygulanması, glisemik kontrol için gerekli olup nakil sonrası mortalite ve morbiditenin anlamlı ölçüde azalmasına katkı sağlamaktadır. Bu derlemede, NODAT gelişiminde rol oynayan risk faktörleri, tanı ve tedavi yaklaşımları güncel bilgiler ışığında özetlenecektir. ANAHTAR SÖZCÜKLER: Böbrek nakli, Böbrek nakli sonrası yeni başlayan diyabet (NODAT), Diabetes mellitus, İnsülin direnci ABSTRACTNew-onset diabetes mellitus after transplantation (NODAT) is common in kidney recipients, threatening health and longevity by predisposing to microvascular and cardiovascular disease and by reducing graft survival. Several risk factors, already present before or arising after transplantation, in particular the employed immunosuppressive regimens, have been related to the development of NODAT. The real incidence of NODAT after kidney transplantation is difficult to establish, because different classification systems and definitions have been employed over the years. Awareness of NODAT and of the NODATrelated factors is of paramount importance for the clinicians in order to individuate higher risk patients and arrange screening strategies. The risk of NODAT can be reduced by planning preventive measures and by tailoring immunosuppressive regimens according to the patient characteristics. Once NODAT has been diagnosed, the administration of specific antihyperglycemic therapy is mandatory to reach a tight glycemic control, which contributes to significantly reduce posttransplant mortality and morbidity. In this review, we summarize current knowledge on risk factors, diagnosis, treatment of NODAT.

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Section: Introductionmentioning

confidence: 99%

“…It affects 2-50% of renal transplant recipients and is associated with graft failure, cardiovascular complications, infection, and mortality [2,3]. As in type 2 diabetes mellitus (T2DM), decreased insulin secretion, increased insulin resistance, or a combination of both are believed to be involved in PTDM [3,4]. Although various risk factors such as older age, obesity, hepatitis C infection, and type of immunosuppressive regimen are well established, they do not fully account for the development of PTDM [3].…”

Section: Introductionmentioning

confidence: 99%

“…As in type 2 diabetes mellitus (T2DM), decreased insulin secretion, increased insulin resistance, or a combination of both are believed to be involved in PTDM [3,4]. Although various risk factors such as older age, obesity, hepatitis C infection, and type of immunosuppressive regimen are well established, they do not fully account for the development of PTDM [3]. Recently, many studies have been conducted to analyze genetic polymorphisms as markers for PTDM [5,6].…”

Section: Introductionmentioning

confidence: 99%

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Association of leptin receptor gene polymorphisms with post-transplant diabetes mellitus: Short report and literature review

Kim¹,

Ihm²,

Lee³

et al. 2017

Transplant Open

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Background: Post-transplant diabetes mellitus (PTDM) is a common and important metabolic complication after renal transplantation. Although genetic variants of the leptin (LEP) and leptin receptor (LEPR) gene have been reported to be associated with insulin resistance and diabetes mellitus, few studies have examined these variants in patients with post-transplant diabetes mellitus (PTDM). In this study, we investigated the association between LEP and LEPR polymorphisms and PTDM in renal transplant recipients. We also reviewed the literature on the genetic variants associated with development of PTDM.

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New onset of diabetes after transplantation — An overview of epidemiology, mechanism of development and diagnosis

Cited by 54 publications

References 85 publications

Asymptomatic Mycotic Aneurysm of Ascending Aorta After Heart Transplantation: A Case Report

Asymptomatic Mycotic Aneurysm of Ascending Aorta After Heart Transplantation: A Case Report

New-Onset Diabetes After Renal Transplantation

Association of leptin receptor gene polymorphisms with post-transplant diabetes mellitus: Short report and literature review

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