New-onset IgA nephropathy following COVID-19 vaccination

Ma, Yaohui; Xu, Gaosi

doi:10.1093/qjmed/hcac185

Cited by 27 publications

(32 citation statements)

References 77 publications

(75 reference statements)

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“…[ 3 ]. Nevertheless, since massive vaccination, growing numbers of clinical cases concerning glomerular diseases such as membranous nephropathy (MN) [ 4 ], IgA nephropathy [ 5 , 6 ], and minimal change disease [ 7 ], etc., have been widely reported.…”

Section: Introductionmentioning

confidence: 99%

New-Onset and Relapsed Membranous Nephropathy post SARS-CoV-2 and COVID-19 Vaccination

2022

Viruses

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Since the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak and COVID-19 vaccination, new-onset and relapsed clinical cases of membranous nephropathy (MN) have been reported. However, their clinical characteristics and pathogenesis remained unclear. In this article, we collected five cases of MN associated with SARS-CoV-2 infection and 37 related to COVID-19 vaccination. Of these five cases, four (4/5, 80%) had acute kidney injury (AKI) at disease onset. Phospholipase A2 receptor (PLA2R) in kidney tissue was negative in three (3/5, 60%) patients, and no deposition of virus particles was measured among all patients. Conventional immunosuppressive drugs could induce disease remission. The underlying pathogenesis included the subepithelial deposition of viral antigens and aberrant immune response. New-onset and relapsed MN after COVID-19 vaccination generally occurred within two weeks after the second dose of vaccine. Almost 27% of patients (10/37) suffered from AKI. In total, 11 of 14 cases showed positive for PLA2R, and 20 of 26 (76.9%) presented with an elevated serum phospholipase A2 receptor antibody (PLA2R-Ab), in which 8 cases exceeded 50 RU/mL. Conventional immunosuppressive medications combined with rituximab were found more beneficial to disease remission for relapsed patients. In contrast, new-onset patients responded to conservative treatment. Overall, most patients (24/37, 64.9%) had a favorable prognosis. Cross immunity and enhanced immune response might contribute to explaining the mechanisms of MN post COVID-19 vaccination.

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Section: Introductionmentioning

confidence: 99%

New-Onset and Relapsed Membranous Nephropathy post SARS-CoV-2 and COVID-19 Vaccination

2022

Viruses

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“…The results of previous studies have shown that in respiratory illnesses, like chronic obstructive pulmonary disease (COPD), cystic brosis (CF) and asthma, a special type of immunoglobulin, called immunoglobulin A (IgA), increases in the body [53]. Further, during an attempt to prevent disease, humans were injected with serum containing IgA and satisfactory results were obtained, which indicated the usefulness of immunoglobulins against the coronavirus [54]. Also, a study by enzyme-linked immunosorbent assay (ELISA) evaluated the level of immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies in patients with the SARS-CoV-2 virus.…”

Section: Discussionmentioning

confidence: 99%

The association of gene expressions of MAP3K7, NF2, STK3 and STK4 therewith Quantum Resonance Magnetic Analyzer (QRMA) in COVID-19 patients

Abdolyousefi,

Kahkesh,

Saadi

et al. 2023

Preprint

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Objectives COVID-19 is initiated by coronavirus infections and it can principally damage the cell’s function of the lung. Assessment of some important genes may capability more operational administration in patients. Therefore, in the recent study, we investigated mRNA and protein expression of MAP3K7, NF2, STK3 and STK4 in virus-infected patients compared with the control group. In addition, we used Quantum Resonance Magnetic Analyzer (QRMA) in order to analyze blood lipids, basic physical quality, lung function and immune system which are divided into twenty-five different variables in patients compared to healthy individuals. Materials and Methods The statistical population was divided into two different groups: patients and healthy individuals. The Expression of the mRNA level of objective genes was assessed with the SYBR Green Real-time Polymerase Chain Reaction method. The protein level expression of target genes was calculated by Enzyme-linked Immunosorbent Assay. Furthermore, in this study, we use QRMA to analyze some quantities such as blood lipids, basic physical quality, lung function and immune system in patients compared to healthy individuals. Statistical analyses were accomplished with SPSS software (version, 18) and Graph-Pad Prism software (Graph-Pad Prism, version 8.0.1). Results The mRNA and protein expressions level of NF2, MAP3K7, STK3 and STK4 genes in the group of patients decreased significantly compared to healthy individuals. The evaluation of blood lipids, basic physical quality, lung function and immune system in the study by QRMA showed that the Arterial oxygen content Paco2, low-density lipoprotein-C, tonsil immune index and immunoglobulin index were significantly higher in patients group compared to healthy individuals. In contrast, the amount of High-density lipoprotein-C, bone marrow index, respiratory immune index and gastrointestinal immune index were significantly lower in patients group compared to healthy individuals. Conclusions Compared to healthy individuals, the amount of mRNA and protein expressed by NF2, MAP3K7, STK3 and STK4 genes was reduced in COVID-19 patients. In truth, these genes have some critical function in some cellular and sub-cellular pathways. Accordingly, when the expression of genes decreased maybe it can increase the influence of coronavirus. Various mechanisms are involved in COVID-19, the increasing of the amount of the arterial oxygen content Paco2, low-density lipoprotein-C, tonsil immune index, immunoglobulin index and decreasing the amount of the High-density lipoprotein-C, bone marrow index, respiratory immune index and gastrointestinal immune index in COVID-19 patients, can be involved in the effects of coronavirus. Therefore, a deep perception of the relationship between these objective genes and QRMA therewith pathogenesis of COVID-19 infections in a larger population with longer supplements is required.

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“…Recently, there have been a series of reports of patients with IgAN in whom gross hematuria developed after SARS-CoV-2 vaccination. 7 Despite the large number of accumulated COVID-19 cases, reports of gross hematuria associated with SARS-CoV-2 infection in patients with IgAN are extremely rare, with only 1 case reported to date. 8 Here, we report the cases of 5 Japanese patients with IgAN who presented with gross hematuria after SARS-CoV-2 infection under different clinical circumstances.…”

Section: Introductionmentioning

confidence: 99%

Gross Hematuria Following SARS-CoV-2 Infection in IgA Nephropathy: A Report of 5 Cases

Ueda¹,

Okabe²,

Shimizu³

et al. 2023

Kidney Medicine

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New-onset IgA nephropathy following COVID-19 vaccination

Cited by 27 publications

References 77 publications

New-Onset and Relapsed Membranous Nephropathy post SARS-CoV-2 and COVID-19 Vaccination

New-Onset and Relapsed Membranous Nephropathy post SARS-CoV-2 and COVID-19 Vaccination

The association of gene expressions of MAP3K7, NF2, STK3 and STK4 therewith Quantum Resonance Magnetic Analyzer (QRMA) in COVID-19 patients

Gross Hematuria Following SARS-CoV-2 Infection in IgA Nephropathy: A Report of 5 Cases

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