New-Onset Diabetes Presenting With Hyperosmolar Hyperglycemic State in a Lean Adolescent With Atypical Rett Syndrome Using Antipsychotics

Vakharia, Mili; Pehlivan, Davut; Hoyos-Martínez, Alfonso; Glaze, Daniel G.; Tosur, Mustafa

doi:10.2337/cd21-0126

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…Adding to the confusion, monogenic forms of diabetes, including neonatal and maturity-onset diabetes of the young (MODY), are relatively rare causes of pediatric-onset diabetes 4 that may resemble T1D or T2D but require genetic testing for diagnosis. Atypical forms of diabetes or atypical presentations of common forms of diabetes are more frequent in non-European individuals 5 – 9 .…”

Section: Introductionmentioning

confidence: 99%

Inaccurate diagnosis of diabetes type in youth: prevalence, characteristics, and implications

Tosur,

Huang,

Inglis

et al. 2024

Sci Rep

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Classifying diabetes at diagnosis is crucial for disease management but increasingly difficult due to overlaps in characteristics between the commonly encountered diabetes types. We evaluated the prevalence and characteristics of youth with diabetes type that was unknown at diagnosis or was revised over time. We studied 2073 youth with new-onset diabetes (median age [IQR] = 11.4 [6.2] years; 50% male; 75% White, 21% Black, 4% other race; overall, 37% Hispanic) and compared youth with unknown versus known diabetes type, per pediatric endocrinologist diagnosis. In a longitudinal subcohort of patients with data for ≥ 3 years post-diabetes diagnosis (n = 1019), we compared youth with steady versus reclassified diabetes type. In the entire cohort, after adjustment for confounders, diabetes type was unknown in 62 youth (3%), associated with older age, negative IA–2 autoantibody, lower C-peptide, and no diabetic ketoacidosis (all, p < 0.05). In the longitudinal subcohort, diabetes type was reclassified in 35 youth (3.4%); this was not statistically associated with any single characteristic. In sum, among racially/ethnically diverse youth with diabetes, 6.4% had inaccurate diabetes classification at diagnosis. Further research is warranted to improve accurate diagnosis of pediatric diabetes type.

show abstract

Section: Introductionmentioning

confidence: 99%

Inaccurate diagnosis of diabetes type in youth: prevalence, characteristics, and implications

Tosur,

Huang,

Inglis

et al. 2024

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…Adding to the confusion, monogenic forms of diabetes, including neonatal and maturity-onset diabetes of the young (MODY), are relatively rare causes of pediatric-onset diabetes [4] that may resemble T1D or T2D but require genetic testing for diagnosis. Atypical forms of diabetes or atypical presentations of common forms of diabetes are more frequent in non-European individuals [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Imprecise Diagnosis of Diabetes Type in Youth: Prevalence, Characteristics, and Implications

Tosur

Huang

Inglis

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

Classifying diabetes at diagnosis is crucial for disease management but increasingly difficult due to overlaps in characteristics between the commonly encountered diabetes types. We evaluated the prevalence and characteristics of youth with diabetes type that was unknown at diagnosis or was revised over time. We studied 2073 youth with new-onset diabetes (median age [IQR]=11.4 [6.2] years; 50% male; 75% White, 21% Black, 4% other race; overall, 37% Hispanic) and compared youth with unknown versus known diabetes type, per pediatric endocrinologist diagnosis. In a longitudinal subcohort of patients with data for ≥3 years post-diabetes diagnosis (n=1019), we compared youth with unchanged versus changed diabetes classification. In the entire cohort, after adjustment for confounders, diabetes type was unknown in 62 youth (3%), associated with older age, negative IA-2 autoantibody, lower C-peptide, and no diabetic ketoacidosis (all, p<0.05). In the longitudinal subcohort, diabetes classification changed in 35 youth (3.4%); this was not statistically associated with any single characteristic. Having unknown or revised diabetes type was associated with less continuous glucose monitor use on follow-up (both, p<0.004). In sum, among racially/ethnically diverse youth with diabetes, 6.5% had imprecise diabetes classification at diagnosis. Further research is warranted to improve accurate diagnosis of pediatric diabetes type.

show abstract

New-Onset Diabetes Presenting With Hyperosmolar Hyperglycemic State in a Lean Adolescent With Atypical Rett Syndrome Using Antipsychotics

Cited by 2 publications

References 18 publications

Inaccurate diagnosis of diabetes type in youth: prevalence, characteristics, and implications

Inaccurate diagnosis of diabetes type in youth: prevalence, characteristics, and implications

Imprecise Diagnosis of Diabetes Type in Youth: Prevalence, Characteristics, and Implications

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