New-onset diabetes in COVID-19 and clinical outcomes: A systematic review and meta-analysis

COVID-19 and diabetes: Association intensify risk factors for morbidity and mortality

“…The fatality rate was observed at 24.96% in COVID-19 associated diabetic patients. Moreover, the numbers of adverse events were also more in DM patient than in non-diabetic subjects [55] . Fawares et al described a case study of a 46-year-old diabetic male patient with beginning physiological parameters that were virtually normal, but who developed DKA and AKI as a result of a growing imbalance in physiological parameters [56] .…”

“… Patient age (yrs) Gender Symptoms (COVID-19 infection) Disease history Medication history Management of co-morbid disease Serious complications observed Ref. 1 53 Male Tiredness, myalgia, ageusia, hyposmia, and one incident of vomiting Diabetes and hypertension Nil Diet, exercise, and lifestyle modification DKA, plasma blood glucose 1543 mg/dL, Glycated hemoglobin 13.0%, blood urea 32.10-136.9 mg/dL, Na: 139-164, mEq/L, K: 4.1-5.3 mEq/L [52] 2 78 Male Mild fever and dry cough Diabetes mellitus, hypertension, and recurrent ischemic stroke Statins, ARBs (losartan), and oral hypoglycemic agents NA On 9 th day of admission: Hyperosmolar hyperglycemic state (HHS), pulse 124b/min, BP 180/100, blood glucose 626 mg/dL, blood urea 64 mg/dL, serum Na: 167 mEq/L, serum K 4.2 mEq/L, serum osmolality 378 mOsm/kg [53] 3 46 Male Weakness, myalgia, hyposmia, vomiting, polydipsia, polyuria Diabetes and hypertension Nil Diet, exercise, and lifestyle modification Diabetic Ketoacidosis (DKA) and Acute Kidney Injury (AKI), thrombocytopenia, pneumonia, CRP 4.03-19.8 mg/ml, Na: 139-164mEq/L, serum K: 4.1-5.3 mEq/L [55] New onset of diabetes after COVID-19 Sr. no. Type of study Mean Age (y) Study population Setting Diabetic prevalence (%) Ref.…”

Novel appearance of hyperglycemia/diabetes, associated with COVID-19

“…We have read with great interest the work by Shrestha et al [ 1 ] regarding new-onset hyperglycemia/ diabetes (DM) in patients with coronavirus disease 2019 (COVID-19). With an erudite meta-analysis the authors found that the pooled prevalence of COVID-19-associated hyperglycemia was 25.23% and that the prevalence of COVID-19-associated new-onset DM was 19.70%[ 1 ].…”

“…Thus, it would be interesting if the results of the study by Shrestha et al [ 1 ] were presented separately-if possible-for critically and non-critically ill patients with COVID-19 and compared to non-COVID-19 patients.…”

Promoting a Syndemic Approach for Cardiometabolic Disease Management During COVID-19: The CAPISCO International Expert Panel

“…At the same time, patients with COVID-19 infection are more prone to the development of new-onset diabetes mellitus (7). Investigators from different areas have emphasized the clinical relevance of the increased incidence of diabetes after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (8,9). Furthermore, COVID-19 is associated with cardiovascular injury attributed to heightened inflammation, endothelial dysfunction and microthrombi formation (10)(11)(12)(13).…”