New-onset diabetes after transplantation

mTOR Inhibition by Rapamycin Prevents β-Cell Adaptation to Hyperglycemia and Exacerbates the Metabolic State in Type 2 Diabetes

“…Posttransplantation diabetes is very common (48); it is conceivable that in this clinical setting, rapamycin adversely affects a preexisting metabolic syndrome and is toxic to endogenous or transplanted pancreatic islets. Indeed, recent studies (49,50) showed that rapamycin impaired islet engraftment and ␤-cell function following islet transplantation.…”

New-Onset Diabetes Mellitus After Heart Transplantation ― Incidence, Risk Factors and Impact on Clinical Outcome ―

“…2 Meanwhile, new-onset DM has not attracted as much clinical attention as pre-existing DM, and there are few studies on its impact on clinical outcomes after heart transplantation. 20 Klingenberg et al reported in the aforementioned study that the overall survival rate was similar between the non-diabetic (n=151) and new-onset DM patients (n=39; P=0.50), 7 and Cho et al also reported that the mid-term survival rate was not significantly different (92.9±4.1% vs. 85.8±3.2%; P=0.22) between the non-diabetic (n=140) and new-onset DM patients (n=54). 8 The present study involved a larger cohort of new-onset DM patients (n=88) during a longer follow-up period (median, 5.4 transplantation compared with new-onset or pre-existing DM patients; (2) there was no significant difference in long-term overall or event-free survival rate between the new-onset DM and the pre-existing DM groups; and (3) advanced age (>50), male gender, and high systolic PAP were significant risk factors for new-onset DM.…”

Post-transplant diabetes mellitus: risk factors, frequency of transplant rejections, and long-term prognosis

“…1 Studies have shown that the cumulative incidence of post-transplant diabetes mellitus in heart transplant recipients reaches about 32% at 5 years, similar to that reported in liver transplant patients. 2 In contrast, estimations about the incidence of new-onset diabetes after renal transplantation vary between 2% and 54%. 1,2 According to the data from the United Renal Data System during the period from 1996 to 2000 in the United States, the cumulative incidence of posttransplant diabetes mellitus was 9.1%, 16.0%, and 24% at 3, 12, and 36 months post-transplant, respectively.…”

“…2 In contrast, estimations about the incidence of new-onset diabetes after renal transplantation vary between 2% and 54%. 1,2 According to the data from the United Renal Data System during the period from 1996 to 2000 in the United States, the cumulative incidence of posttransplant diabetes mellitus was 9.1%, 16.0%, and 24% at 3, 12, and 36 months post-transplant, respectively. 3 In a study performed in Egypt assessing the most important post-transplant complications that resulted in death with functioning grafts, diabetes mellitus was found to be present in 22.9% of all the patients (hypertension in 59.5%, medical infections in 51.5%, hepatic complications in 22.9% and malignancies in 13%).…”