New-Onset Diabetes After Renal Transplantation (NODAT): Is It a Risk Factor for Renal Cell Carcinoma or Renal Failure?

Nie, Hai-bo; Wang, Wei; Zhao, Yang; Zhang, Xiaoming; Xiao, Yao; Zeng, Quan; Zhang, Changzhen; Zhang, Lei

doi:10.12659/aot.909099

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…Despite screening for RCC among KTx candidates, de novo RCC has been reported among KTx patients in both native kidneys [11,12,13,14,15,16,17,18], and transplanted kidneys [17,19,20]. However, the incidence and incidence trends of RCC among KTx patients remain unclear [11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42].…”

Section: Introductionmentioning

confidence: 99%

Incidence and Mortality of Renal Cell Carcinoma after Kidney Transplantation: A Meta-Analysis

Chewcharat

Thongprayoon

Bathini

et al. 2019

JCM

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Background: The incidence and mortality of renal cell carcinoma (RCC) after kidney transplantation (KTx) remain unclear. This study's aims were (1) to investigate the pooled incidence/incidence trends, and (2) to assess the mortality/mortality trends in KTx patients with RCC. Methods: A literature search was conducted using the MEDLINE, EMBASE and Cochrane databases from inception through October 2018. Studies that reported the incidence or mortality of RCC among kidney transplant recipients were included. The pooled incidence and 95% CI were calculated using a random-effect model. The protocol for this meta-analysis is registered with PROSPERO; no. CRD42018108994. Results: A total of 22 observational studies with a total of 320,190 KTx patients were enrolled. Overall, the pooled estimated incidence of RCC after KTx was 0.7% (95% CI: 0.5–0.8%, I2 = 93%). While the pooled estimated incidence of de novo RCC in the native kidney was 0.7% (95% CI: 0.6–0.9%, I2 = 88%), the pooled estimated incidence of RCC in the allograft kidney was 0.2% (95% CI: 0.1–0.4%, I2 = 64%). The pooled estimated mortality rate in KTx recipients with RCC was 15.0% (95% CI: 7.4–28.1%, I2 = 80%) at a mean follow-up time of 42 months after RCC diagnosis. While meta-regression analysis showed a significant negative correlation between year of study and incidence of de novo RCC post-KTx (slopes = −0.05, P = 0.01), there were no significant correlations between the year of study and mortality of patients with RCC (P = 0.50). Egger's regression asymmetry test was performed and showed no publication bias in all analyses. Conclusions: The overall estimated incidence of RCC after KTX was 0.7%. Although there has been a potential decrease in the incidence of RCC post-KTx, mortality in KTx patients with RCC has not decreased over time.

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Section: Introductionmentioning

confidence: 99%

Incidence and Mortality of Renal Cell Carcinoma after Kidney Transplantation: A Meta-Analysis

Chewcharat

Thongprayoon

Bathini

et al. 2019

JCM

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“…Transplantation is a replacement treatment alternative for patients with end‐stage kidney disease (Andersen et al, 2019). However, despite the benefits of renal transplantation, recipients encounter several problems including renal toxicity (Walsh & Dinavahi, 2016), hypertension (Severova‐Andreevska, Danilovska, Sikole, Popov, & Ivanovski, 2019), new‐onset diabetes mellitus (Nie et al, 2019), dyslipidemia and hyperuricemia following with the immunosuppressive drugs (Robledo et al, 2018). Furthermore, organ rejection can occur acutely or many years after transplantation to cause graft loss (Roth, 2017), and common complications of transplantation, such as malignancy, cardiovascular disease and infection significantly reduce the life expectancy of recipients (Kazımoğlu et al, 2019; Walsh & Dinavahi, 2016).…”

Section: Literature Reviewmentioning

confidence: 99%

Care Needs for Organ Transplant Recipients Scale: Development and psychometric testing

Chang

Lai

Tsai

et al. 2020

Journal of Renal Care

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Background Needs assessment can determine how large the gap is between needs and available services; however, no tools are available to assess the unmet needs of renal transplant recipients. Objectives The aim of this study was to develop the Care Needs for Organ Transplant Recipients Scale (CNOTRS) and examine its psychometric properties. Design A cross‐sectional design for instrument development and psychometric testing. Participants In total, 217 renal transplant recipients were recruited through convenience sampling. Methods An initial 36‐item CNOTRS was developed after a comprehensive literature review. After the CNOTRS was tested through content validity and face validity, the factor structure was explored using exploratory factor analysis (EFA). Convergent validity was examined using Pearson's correlation between the CNOTRS and Hospital Anxiety and Depression Scale (HADS). Known‐group validity was tested by comparing CNOTRS scores of patients grouped based on whether they had experienced complications or rejection. Results Twenty‐eight items with three factors (namely daily care and social interaction needs, psychological needs, and health system and service needs) were identified in EFA by parallel analysis and Velicer's MAP test. The psychological needs domain had a stronger positive correlation with the HADS than the other two domains. The known‐group validity was supported as a significant association between complications or rejection occurrence and unmet needs. The Cronbach's α of the CNOTRS was 0.94. Conclusions The CNOTRS demonstrated satisfactory reliability and validity to assess the care needs for renal transplant recipients and can assist health care professionals to tailor more personalised care for their individual needs.

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New-onset diabetes after kidney transplantation: Assessing urinary Wilm's tumor-1 protein to predict renal allograft dysfunction

de Andrade,

Souza,

Galdino

et al. 2024

Advances in Medical Sciences

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New-Onset Diabetes After Renal Transplantation (NODAT): Is It a Risk Factor for Renal Cell Carcinoma or Renal Failure?

Cited by 3 publications

References 18 publications

Incidence and Mortality of Renal Cell Carcinoma after Kidney Transplantation: A Meta-Analysis

Incidence and Mortality of Renal Cell Carcinoma after Kidney Transplantation: A Meta-Analysis

Care Needs for Organ Transplant Recipients Scale: Development and psychometric testing

New-onset diabetes after kidney transplantation: Assessing urinary Wilm's tumor-1 protein to predict renal allograft dysfunction

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