New-Onset Constipation at Acute Stage After First Stroke

Su, Yongjing; Zhang, Xiaoyan; Zeng, Jinsheng; Pei, Zhong; Cheung, Raymond Tak Fai; Zhou, Qiuping; Li, Ling; Yu, Jian; Jinquan, Tan; Zhang, Zhenlu

doi:10.1161/strokeaha.108.534776

Cited by 73 publications

(50 citation statements)

References 26 publications

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“…[9][10][11]21 However, no in vivo imaging studies showed previously that acute brain injury results in robust and rapid changes in the gut and gave insight into the mechanisms. The SPECT imaging with 99mTc-DTPA revealed early and transient changes in the gut after experimental stroke as identified by increases in DTPA signal 2 hours after reperfusion (by 64%, P = 0.025, Figures 5A and 5C), which recovered fully by Twenty-four hours after MCAo, DTPA signal intensity in the striatum correlates significantly with BBB injury as measured by IgG staining on brain sections.…”

Section: Experimental Stroke Leads To Rapid Gut Barrier Function Chanmentioning

confidence: 99%

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A Novel SPECT-Based Approach Reveals Early Mechanisms of Central and Peripheral Inflammation after Cerebral Ischemia

Szigeti

Horváth

Veres

et al. 2015

J Cereb Blood Flow Metab

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Inflammation that develops in the brain and peripheral organs after stroke contributes profoundly to poor outcome of patients. However, mechanisms through which inflammation impacts on brain injury and overall outcome are improperly understood, in part because the earliest inflammatory events after brain injury are not revealed by current imaging tools. Here, we show that singlephoton emission computed tomography (NanoSPECT/CT Plus) allows visualization of blood brain barrier (BBB) injury after experimental stroke well before changes can be detected with magnetic resonance imaging (MRI). Early 99mTc-DTPA (diethylene triamine pentaacetic acid) signal changes predict infarct development and systemic inflammation preceding experimental stroke leads to very early perfusion deficits and increased BBB injury within 2 hours after the onset of ischemia. Acute brain injury also leads to peripheral inflammation and immunosuppression, which contribute to poor outcome of stroke patients. The SPECT imaging revealed early (within 2 hours) changes in perfusion, barrier function and inflammation in the lungs and the gut after experimental stroke, with good predictive value for the development of histopathologic changes at later time points. Collectively, visualization of early inflammatory changes after stroke could open new translational research avenues to elucidate the interactions between central and peripheral inflammation and to evaluate in vivo 'multi-system' effects of putative anti-inflammatory treatments.

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Section: Experimental Stroke Leads To Rapid Gut Barrier Function Chanmentioning

confidence: 99%

“…Translocation of gut bacteria after stroke has also been documented. [9][10][11] However, it is currently unclear whether brain injury has organ-specific effects, which could be revealed with imaging techniques in vivo.…”

Section: Introductionmentioning

confidence: 99%

A Novel SPECT-Based Approach Reveals Early Mechanisms of Central and Peripheral Inflammation after Cerebral Ischemia

Szigeti

Horváth

Veres

et al. 2015

J Cereb Blood Flow Metab

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“…Thus, in the literature, the prevalence of intestinal constipation in patients suffering from stroke sequelae can range between 22.9% a 60%, although different definitions and research phases are identified in the studies. In some cases, prevalence rates were investigated in more acute patients or after a recent injury [10][11]19 and in others with chronic patients. 9,13 In the present study, this difference can be justified by the method -retrospective analysis of electronic patient chart -and the consequent impossibility to investigate other intestinal constipation symptoms.…”

Section: Discussionmentioning

confidence: 99%

Disfunção intestinal em pacientes com lesão cerebral decorrente de acidente vascular cerebral e traumatismo craniencefálico: estudo retrospectivo de uma série de casos

Dourado¹,

Engler²,

Oliveira³

2012

Texto contexto - enferm.

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Bowel dysfunction is a common complaint among patients with brain damage due to stroke and traumatic brain injury. The aim of this study was to investigate the prevalence of bowel dysfunction (anal incontinence and intestinal constipation) in patients with brain damage due to stroke and traumatic brain injury admitted for rehabilitation. This is a retrospective case series study, based on the analysis of data from 138 charts of patients admitted in the first half of 2009. The prevalence of bowel dysfunction was 41%, with 33 (24%) cases of anal incontinence and 37 (27%) cases of intestinal constipation. Motor impairment, mobility aid, changes in memory and communication were associated with the presence of anal incontinence. The prevalence of bowel dysfunction is high in this population. Early identification of the symptoms and its related factors promoting bowel retraining, may help to improve the quality of life of patients with bowel dysfunction. DESCRIPTORS:Constipation. Fecal incontinence. Stroke. Traumatic brain injury. DISFUNÇÃO INTESTINAL EM PACIENTES COM LESÃO CEREBRAL DECORRENTE DE ACIDENTE VASCULAR CEREBRAL E TRAUMATISMO CRANIENCEFÁLICO: ESTUDO RETROSPECTIVO DE UMA SÉRIE DE CASOS RESUMO:A disfunção intestinal é uma queixa comum entre pacientes com lesão cerebral decorrente de Acidente Vascular Cerebral e Traumatismo Craniencefálico. Este estudo objetivou pesquisar a prevalência da disfunção intestinal (incontinência anal e constipação intestinal) em pacientes com lesão cerebral decorrente de Acidente Vascular Cerebral e Traumatismo Craniencefálico, admitidos para reabilitação. Trata-se de um estudo retrospectivo de uma série de casos, a partir da análise dos dados de 138 prontuários de pacientes internados no primeiro semestre de 2009. A prevalência de disfunção intestinal foi 41%, sendo 33 (24%) incontinência anal e 37 (27%) constipação intestinal. Comprometimento motor, auxílio locomoção, alterações de memória e comunicação estiveram associados à presença de incontinência anal. A prevalência de disfunção intestinal é alta nessa população, identificá-la precocemente, bem como os fatores relacionados, e promover a reeducação intestinal, poderá contribuir para melhora na qualidade de vida dessas pessoas.DESCRITORES: Constipação intestinal. Incontinência fecal. Acidente vascular cerebral. Traumatismos encefálicos. DISFUNCCIÓN INTESTINAL EN PACIENTES CON DAÑO CEREBRAL COMO RESULTADO DE UNA LESION CEREBRAL TRAUMÁTICA Y ACCIDENTE CEREBROVASCULAR: UN ESTUDIO RETROSPECTIVO DE UNA SERIE DE CASOSRESUMEN: La disfunción del intestino es una queja común entre los pacientes con daño cerebral debido a una lesión cerebral traumática y accidente cerebrovascular. Este estudio tuvo como objetivo investigar la prevalencia de disfunción del intestino (incontinencia y constipación) en pacientes con daño cerebral debido a una lesión cerebral traumática y accidente cerebrovascular admitidos para la rehabilitación. Este es un estudio retrospectivo de una serie de casos a partir del análisis de los datos de 138 exped...

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“…Suvei dilakukan kembali tahun 2010 pada 8100 sampel berusia di atas 20 tahun dari empat negara termasuk Indonesia diperoleh hasil dari wawancara 16,2% mengalami konstipasi (Wald, 2010). Akan tetapi, Su, et al, (2009) melaporkan pasien stroke yang mengalami masalah konstipasi 55,2% dari 154 pasien pada serangan stroke yang pertama.…”

Section: Pendahuluanunclassified

Mengatasi Konstipasi Pasien Stroke dengan Masase Abdomen dan Minum Air Putih Hangat

Ginting

Waluyo

Sukmarini

2015

JKI

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AbstrakPerawat memiliki peranan yang penting mengatasi konstipasi pada pasien stroke selama perawatan di rumah sakit. Penelitian ini bertujuan untuk mengetahui perbedaan masase abdomen dengan masase abdomen dan minum air putih hangat pada pasien stroke yang mengalami konstipasi terhadap proses defekasi di Kota Medan. Penelitian kuasi eksperimen dengan dua kelompok intervensi dan satu kelompok kontrol menggunakan pendekatan purposive sampling dengan total empat puluh tujuh responden, masing-masing empat belas responden kelompok masase abdomen, enam belas responden kelompok masase abdomen dan minum air putih hangat, dan tujuh belas responden intervensi standar diobservasi setiap hari selama tujuh hari. Proses defekasi terhadap ketiga kelompok dilihat dari waktu terjadinya defekasi antara kelompok intervensi I dan II dengan nilai p= 0,015, dan dari frekuensi defekasi antara kelompok intervensi II dan kelompok kontrol dengan nilai p= 0,000. Hasil penelitian ini diharapkan dapat menjadi evidence based practice dalam asuhan keperawatan medikal bedah dalam memberikan intervensi keperawatan terhadap pasien stroke yang mengalami konstipasi sehingga perawatan terapi komplementer di bidang keperawatan dapat dikenal dan memberikan manfaat sebagai pencegahan dan pengobatan alami.

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New-Onset Constipation at Acute Stage After First Stroke

Abstract: New-onset constipation is a common complication of acute stroke. Its occurrence is associated with dependence and use of bedpan for defecation. Its development may predict a poor outcome at 12 weeks in patients with moderately severe stroke.

Cited by 73 publications

References 26 publications

A Novel SPECT-Based Approach Reveals Early Mechanisms of Central and Peripheral Inflammation after Cerebral Ischemia

A Novel SPECT-Based Approach Reveals Early Mechanisms of Central and Peripheral Inflammation after Cerebral Ischemia

Disfunção intestinal em pacientes com lesão cerebral decorrente de acidente vascular cerebral e traumatismo craniencefálico: estudo retrospectivo de uma série de casos

Mengatasi Konstipasi Pasien Stroke dengan Masase Abdomen dan Minum Air Putih Hangat

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