New OFSEP recommendations for MRI assessment of multiple sclerosis patients: Special consideration for gadolinium deposition and frequent acquisitions

Brisset, Jean-Christophe; Hannoun, Salem; Améli, Roxana; Anxionnat, René; Audoin, Bertrand; Attyé, Arnaud; Bannier, Élise; Barillot, Christian; Salem, Douraı̈ed Ben; Boncoeur-Martel, M. P.; Bonhomme, Gabrielle R.; Bonneville, Fabrice; Billen, Claire; Brisset, Jean Christophe; Cervenanski, F.; Claise, Béatrice; Commowick, Olivier; Constans, Jean-Marc; Dardel, Pascal; Desal, Hubert; Denis, Vincent; Durand‐Dubief, Françoise; Ferré, Jean-Christophe; Gaultier, Aurélie; Gérardin, Emmanuel; Glattard, T.; Grand, Sylvie; Grenier, Thomas; Guillevin, Rémy; Guttmann, Charles R.G.; Krainik, Alexandre; Kremer, Stéphane; Lion, Stéphanie; Champfleur, Nicolas Menjot de; Mondot, Lydiane; Outteryck, Olivier; Pyatigorskaya, Nadya; Pruvo, Jean‐Pierre; Rabasté, Sylvain; Ranjeva, Jean Philippe; Roch, J. Albendea; Sadik, Jean-Claude; Sappey–Marinier, Dominique; Savatovsky, Julien; Tanguy, Jean‐Yves; Tourbah, Ayman; Tourdias, Thomas; Brochet, Bruno; Casey, Romain; Cotton, François; Sèze, Jérôme De; Douek, P.; Guillemin, Françis; Laplaud, David‐Axel; Lebrun-Frénay, Christine; Mansuy, L; Moreau, T.; Olaiz, Javier; Pelletier, Jean; Rigaud‐Bully, Claire; Stankoff, Bruno; Vukusic, Sandra; Debouverie, M.; Edan, Gilles; Ciron, Jonathan; Lubetzki, Catherine; Vermersch, P.; Labauge, Pierre; Defer, Gilles; Berger, Ėric; Clavelou, Pierre; Gout, Olivier; Thouvenot, Éric; Heinzlef, Olivier; Al-Khedr, A.; Bourre, Bertrand; Casez, Olivier; Cabre, Philippe; Montcuquet, Alexis; Créange, Alain; Camdessanché, J.-P.; Bakchine, Serge; Maurousset, Aude; Patry, I.; Broucker, T. de; Pottier, Corinne; Neau, Jean‐Philippe; Labeyrie, Céline; Nifle, Chantal

doi:10.1016/j.neurad.2020.01.083

Cited by 50 publications

(43 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Groups 2 and 3 were selected from the “Observatoire Francais de la Sclérose En Plaques” (OFSEP) database 8 . Group‐2 included 30 MS patients with 3DT1, 3DFLAIR, and 3DDIR available 9 . Group‐3 included 164 MS patients with 2DT2, and 3DFLAIR available 9,10 .…”

Section: Methodsmentioning

confidence: 99%

“…Group‐2 included 30 MS patients with 3DT1, 3DFLAIR, and 3DDIR available 9 . Group‐3 included 164 MS patients with 2DT2, and 3DFLAIR available 9,10 . Images were acquired on three different MRI machines following the common standardized OFSEP MRI protocol 9,10 .…”

Section: Methodsmentioning

confidence: 99%

“…Group‐3 included 164 MS patients with 2DT2, and 3DFLAIR available 9,10 . Images were acquired on three different MRI machines following the common standardized OFSEP MRI protocol 9,10 . 2DT2 sequence was acquired and evaluated in the axial plane, whereas 3D sequences were acquired in the sagittal plane and reconstructed with high‐resolution in axial and coronal planes (Table 1 and Figure 1).…”

Section: Methodsmentioning

confidence: 99%

“…It is based on a multicentric MRI dataset acquired on three different MR systems. Even if MRI protocols and sequences parameters were standardized according to the OFSEP MRI protocol,8,9 some biases related to software upgrade and machine type and age still persist. Nonetheless, only images with a good signalto-noise ratio and of high quality were included in this study, thereby reducing as much as possible interference.…”

mentioning

confidence: 99%

See 3 more Smart Citations

MRI to detect and localize the area postrema in multiple sclerosis: The role of 3D‐DIR and 3D‐FLAIR

Farges

Hannoun

Benini

et al. 2021

Journal of Neuroimaging

Self Cite

View full text Add to dashboard Cite

Background And Purpose: Area postrema (AP) is a highly vascularized paired 2 mm-long anatomical structure, localized on the dorsal inferior surface of the medulla oblongata, at the caudal end of the fourth-ventricle. AP is principally affected in AP syndrome, which is commonly associated with autoimmune inflammatory diseases, including essentially neuromyelitis optica spectrum disorder (NMOSD). The aim of this study is to assess the best cerebral MRI sequences and planes for AP detection in order to assist or aid in the diagnosis of difficult NMOSD cases.Methods: 3DT1, 2DT2, 3D-fluid-attenuated inversion recovery (3DFLAIR), and 3Ddouble inversion recuperation (3DDIR), routinely used in inflammatory diseases, were analyzed and scored based on quality (0-2), and ability to detect AP in each plane (0 = no detection, 1 = probable detection, 2 = obvious detection). Based on image availability, subjects were divided into three groups: Group-1, including 100 randomly selected subjects with 3DT1 and 3DFLAIR, Group-2, including 30 multiple sclerosis (MS) patients from the "Observatoire Français de la Sclérose En Plaques" (OFSEP) with 3DT1, 3DFLAIR, and 3DDIR, and Group-3, including 164 OFSEP MS patients with 3DFLAIR and 2DT2.Results: AP was undetectable on 3DT1 and 2DT2. AP was detected in 87% of 3DFLAIR in Group-1, 90% in Group-2, and 90% in Group-3. AP was also detected in 100% of 3DDIR images in the axial plane.Conclusions: As evidenced, AP was easily assessed on 3DDIR and 3DFLAIR emphasizing the importance of adding these sequences to NMOSD MRI-protocols. Moreover, the most effective imaging plane in identifying AP was the axial plane.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

MRI to detect and localize the area postrema in multiple sclerosis: The role of 3D‐DIR and 3D‐FLAIR

Farges

Hannoun

Benini

et al. 2021

Journal of Neuroimaging

Self Cite

View full text Add to dashboard Cite

show abstract

“…In this Controversies in MS , the utility of post-contrast magnetic resonance imaging (MRI) to evaluate disease activity in multiple sclerosis (MS) is debated in light of the safety concerns secondary to Gadolinium tissue deposition. 1 This public health issue is of high relevance for providers involved in the care of patients with MS, as post-Gadolinium MRI is the most powerful paraclinical tool for unraveling symptomatic and clinically silent disease, associated with acute inflammation. 2 Thus, reaching a consensus opinion is important.…”

mentioning

confidence: 99%

Gadolinium should always be used to assess disease activity in MS – Commentary

Bagnato

2020

Mult Scler

View full text Add to dashboard Cite

Whole Brain Adiabatic T_1rho and Relaxation Along a Fictitious Field Imaging in Healthy Volunteers and Patients With Multiple Sclerosis: Initial Findings

Jambor

Steiner

Pesola

et al. 2021

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Background In preclinical models of multiple sclerosis (MS), both adiabatic T1rho (T1ρadiab) and relaxation along a fictitious field (RAFF) imaging have demonstrated potential to noninvasively characterize MS. Purpose To evaluate the feasibility of whole brain T1ρadiab and RAFF imaging in healthy volunteers and patients with MS. Study Type Single institutional clinical trial. Subjects 38 healthy volunteers (24–69 years) and 21 patients (26–59 years) with MS. Five healthy volunteers underwent a second MR examination performed within 8 days. Clinical disease severity (The Expanded Disability Status Scale [EDSS] and The Multiple Sclerosis Severity Score [MSSS]) was evaluated at baseline and 1‐year follow‐up (FU). Field Strength/Sequence RAFF in second rotating frame of reference (RAFF2) was performed at 3 T using 3D‐fast‐field echo with magnetization preparation, RF amplitude of 11.74 μT while the corresponding value for T1ρadiab was 13.50 μT. T1‐, T2‐, and FLAIR‐weighted images were acquired with reconstruction voxel size 1.0 × 1.0 × 1.0 mm3. Assessment The parametric maps of T1ρadiab and RAFF2 (TRAFF2) were calculated using a monoexponential model. Semi‐automatic segmentation of MS lesions, white matter (WM), and gray matter (GM), and WM tracks was performed using T1‐, T2‐, and FLAIR‐weighted images. Statistical Tests Regression analysis was used to evaluate correlation of T1ρadiab and TRAFF2 with age and disease severity while a Friedman test followed by Wilcoxon Signed Rank test for differences between tissue types. Short‐term repeatability was evaluated on voxel level. Results Both T1ρadiab and TRAFF2 demonstrated good short‐term repeatability with relative differences on voxel level in the range of 6.1%–11.9%. Differences in T1ρadiab and TRAFF2 between the tissue types in MS patients were significant (P < 0.05). T1ρadiab and TRAFF2 correlated (P < 0.001) with baseline EDSS/MSSM and disease progression at FU (P < 0.001). Data Conclusion Whole brain T1ρadiab and TRAFF2 at 3 T was feasible with significant differences in T1ρadiab and TRAFF2 values between tissues types and correlation with disease severity. Evidence Level 1 Technical Efficacy Stage 1

show abstract

New OFSEP recommendations for MRI assessment of multiple sclerosis patients: Special consideration for gadolinium deposition and frequent acquisitions

Cited by 50 publications

References 42 publications

MRI to detect and localize the area postrema in multiple sclerosis: The role of 3D‐DIR and 3D‐FLAIR

MRI to detect and localize the area postrema in multiple sclerosis: The role of 3D‐DIR and 3D‐FLAIR

Gadolinium should always be used to assess disease activity in MS – Commentary

Whole Brain Adiabatic T_1rho and Relaxation Along a Fictitious Field Imaging in Healthy Volunteers and Patients With Multiple Sclerosis: Initial Findings

Contact Info

Product

Resources

About

New OFSEP recommendations for MRI assessment of multiple sclerosis patients: Special consideration for gadolinium deposition and frequent acquisitions

Cited by 50 publications

References 42 publications

MRI to detect and localize the area postrema in multiple sclerosis: The role of 3D‐DIR and 3D‐FLAIR

MRI to detect and localize the area postrema in multiple sclerosis: The role of 3D‐DIR and 3D‐FLAIR

Gadolinium should always be used to assess disease activity in MS – Commentary

Whole Brain Adiabatic T1rho and Relaxation Along a Fictitious Field Imaging in Healthy Volunteers and Patients With Multiple Sclerosis: Initial Findings

Contact Info

Product

Resources

About

Whole Brain Adiabatic T_1rho and Relaxation Along a Fictitious Field Imaging in Healthy Volunteers and Patients With Multiple Sclerosis: Initial Findings