New observations on antigenic diversification of RNA viruses. Antigenic variation is not dependent on immune selection

Domingo, Esteban; Díez, José Manuel Olivares; Martı́nez, Miguel Ángel; Hernández, Jordi; Holguín, África; Borrego, Belén; Mateu, Mauricio G.

doi:10.1099/0022-1317-74-10-2039

Cited by 131 publications

(69 citation statements)

References 60 publications

(42 reference statements)

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“…FMDV has been one of the model systems for the study of the high potential for variation of RNA viruses (reviewed in [79][80][81]). The studies made by Domingo et al [78], mainly working with FMDV, and Holland et al [117] using the vesicular stomatitis virus (VSV) as model systems, have provided important experimental and conceptual support to the notion that populations of RNA viruses consist of multiple variants collectively termed quasispecies [87].…”

Section: Variability In Cell Culturementioning

confidence: 99%

Foot-and-mouth disease virus: a long known virus, but a current threat

et al. 2001

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-Foot-and-mouth disease virus (FMDV) was the first animal virus identified. Since then, FMDV has become a model system in animal virology and a considerable amount of information on its structure, biology and vaccinology has been obtained. However, the disease that this virus produces (FMD) still constitutes one of the main animal health concerns. In this review, we have attempted to summarise the state of the knowledge in different basic and applied areas of FMDV research, with emphasis on those aspects relevant to the control of the disease. FMDV / structure / immunity / vaccine / variability / diagnosisRésumé -Le virus de la fièvre aphteuse : un virus connu de longue date, qui demeure une menace. Le virus de la fièvre aphteuse a été le premier virus animal identifié. Depuis lors, il est devenu un système modèle en virologie animale, et une quantité importante d'informations sur sa structure, sa biologie et sa vaccinologie a été obtenue. Cependant la maladie provoquée par ce virus constitue encore une inquiétude majeure en santé animale. Dans cette revue, nous avons tenté de résumer l'état des connaissances dans différents domaines de recherche, à la fois fondamentaux et appliqués, sur le virus de la fièvre aphteuse, en mettant l'accent sur les aspects relatifs au contrôle de la maladie. virus de la fièvre aphteuse / immunité / vaccin / variabilité / diagnostic

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Section: Variability In Cell Culturementioning

confidence: 99%

Foot-and-mouth disease virus: a long known virus, but a current threat

et al. 2001

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“…Computer analysis indicates that this hypervariable region is very hydrophilic and antigenic (data not shown). It has been proposed that antigenic variation of viruses is the result of direct selection of variants by host immune responses, although new observations suggest that this may not be true for all viruses (reviewed by Domingo et al, 1993). This hypervariable region is likely to have evolved because of selection pressure by the host immune system; thus providing a possible explanation for the observed antigenic diversity among PRRSV isolates (Wensvoort et al, 1992;Nelson et al, 1993).…”

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confidence: 99%

Sequence comparison of open reading frames 2 to 5 of low and high virulence United States isolates of porcine reproductive and respiratory syndrome virus

Meng

Paul

Halbur

et al. 1995

Journal of General Virology

144

120

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The sequences ofORFs 2 to 5 of five United States (US) porcine reproductive and respiratory syndrome virus (PRRSV) isolates with differing virulence were determined. The nucleotide and deduced amino acid sequences of these isolates were compared with those of other known PRRSV isolates. The amino acid sequence identity between seven US PRRSV isolates was 91-99 % in ORF 2, 86-98 % in ORF 3, 92-99 % in ORF 4 and 88-97 % in ORF 5. The low virulence US isolate had highest sequence variation in ORFs 2 to 4 compared to the other US isolates. A hypervariable region with antigenic potential was identified within the major envelope glycoprotein. Phylogenetic analysis of ORFs 2 to 7 indicated the existence of at least three minor genotypes within the major US genotype. The low virulence US isolate formed a branch distinct from the other US isolates. The results of this study have implications for both the taxonomy of PRRSV and vaccine development.

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“…10 However, there are nonimmune-driven effects that can also result in quasispecies change and evolution. 11 These may reflect host metabolic changes or other events. One such event in particular has been studied extensively.…”

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confidence: 99%