New Observations in a Child with Angiofollicular Lymph Node Hyperplasia (Castlemanʼs Disease) Originated from the Mesenteric Root

Hung, Iou‐Jih; Kuo, Tseng‐Tong; Lin, Jainn-Jim

doi:10.1097/00043426-199208000-00013

Cited by 20 publications

(9 citation statements)

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“…4,5,7 Because of its vascularization, there is risk of massive hemorrhage during surgery. 5 The unicentric plasma cell variant (U-PCV) occurs in approximately 20% of patients with CD. It is characterized by hypertrophy of a single lymph node chain.…”

Section: Discussionmentioning

confidence: 99%

Retroperitoneal unicentric Castleman's disease (giant lymph node hyperplasia): case report

et al. 2007

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CONTEXT AND OBJECTIVE: Castleman's disease, or giant lymph node hyperplasia, is a rare disorder of the lymphoid tissue that causes lymph node enlargement. It is considered benign in its localized form, but aggressive in the multicentric type. The definitive diagnosis is based on postoperative pathological findings. The aim here was to describe a case of retroperitoneal unicentric Castleman's disease in the retroperitoneum. CASE REPORT: A 61-year old white male with weight loss and listlessness presented with moderate arterial hypertension and leukopenia. Abdominal tomography revealed a 5 x 4 x 5 cm oval mass of low attenuation, with inner calcification and intense enhancement on intravenous contrast, located in the retroperitoneal region, between the left kidney and the aorta, at the renal hilus. Exploratory laparotomy revealed a non-pulsatile solid oval mass situated in the retroperitoneum, adjacent to the left renal hilus. The retroperitoneal lesion was removed in its entirety. Examination of frozen samples revealed benign lymph node tissue and histopathological examination of the surgical sample revealed hyaline-vascular giant lymph node hyperplasia (Castleman's disease). The patient was discharged on the 12th day without significant events. Two months after the operation, the patient was readmitted with severe cardiac insufficiency, acute renal failure and bronchopneumonia, which progressed to acute respiratory insufficiency, sepsis and death.

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Section: Discussionmentioning

confidence: 99%

Retroperitoneal unicentric Castleman's disease (giant lymph node hyperplasia): case report

et al. 2007

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“…Several authors have recommended abdominal CT or even exploratory laparotomy in children with growth retardation, hypergammaglobulinemia, and anemia [ 5,12,14,15,16,17]. While supporting this advice we would like to emphasize the role of exploratory laparotomy in cases with a typical history.…”

Section: Discussionmentioning

confidence: 96%

“…As with adult cases, most pediatric cases are detected incidentally or because of local growth producing a mass [4]. Early diagnosis of mesenteric CD is difficult, especially in children [12]. This is reflected in the long-standing nature of many of the cases, Goebel et al [13] and Bjarnason et al [8] reporting cases of 20 years' and 11 years' duration, respectively.…”

Section: Introductionmentioning

confidence: 99%

Castleman's disease of the mesentery in a child: A case of seven years' duration without typical x-ray findings

Mäkipernaa¹,

Ashorn²,

Arajärvi³

et al. 1997

Med. Pediatr. Oncol.

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“…However, the laboratory data became normal only after removal of the mass 8. Most cases with the syndrome was associated with CD of P‐C or mixed type 3,9,10. Only 2 of the 11 patients with CD and the syndrome showed intrathoracic involvement 10,11.…”

Section: Discussionmentioning

confidence: 99%

Paraneoplastic syndrome and intrathoracic Castleman disease

Hung

Lin

Yang

2005

Pediatric Blood & Cancer

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We report two cases of intrathoracic Castleman disease presenting with paraneoplastic syndrome. Patient 1 was a 10-year-old girl with short stature. She was found to have delayed bone age, slow growth velocity, and iron-deficiency anemia, which was refractory to treatment. Thrombocytosis and hypergammaglobulinemia were later detected. Chest X-ray revealed a hilar mass. Patient 2 was a 14-year-old boy who had severe cough, progressive mucocutaneous erosion, and dermatitis. Chest X-ray showed a mediastinal mass. Sections of skin biopsy showed findings consistent with pemphigus disease. In each case, the histological diagnosis of Castleman disease was made.

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New Observations in a Child with Angiofollicular Lymph Node Hyperplasia (Castlemanʼs Disease) Originated from the Mesenteric Root

Cited by 20 publications

References 0 publications

Retroperitoneal unicentric Castleman's disease (giant lymph node hyperplasia): case report

Retroperitoneal unicentric Castleman's disease (giant lymph node hyperplasia): case report

Castleman's disease of the mesentery in a child: A case of seven years' duration without typical x-ray findings

Paraneoplastic syndrome and intrathoracic Castleman disease

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