New nomenclature for mpox (monkeypox) and monkeypox virus clades

Ulaeto, David O.; Агафонов, А. В.; Burchfield, Jennifer; Carter, Lisa; Happi, Christian; Jakob, Robert; Krpelanová, Eva; Kuppalli, Krutika; Lefkowitz, Elliot J.; Mauldin, Matthew R; Oliveira, Túlio de; Onoja, Anyebe Bernard; Otieno, James R.; Rambaut, Andrew; Subissi, Lorenzo; Yinka-Ogunleye, Adesola; Lewis, Rosamund

doi:10.1016/s1473-3099(23)00055-5

Cited by 61 publications

(47 citation statements)

References 5 publications

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“…Thus, the epidemiological differences of the 2022 outbreak suggested the use of the novel nomenclature to better characterize this new clade (defined B.1) and to avoid offense or economic effect for any ethnic, regional, or other groups. 4 Since the beginning of the MPXV outbreak, more than 86 309 laboratory-confirmed cases in 110 countries have been reported with 107 deaths. 2 The cases primarily involved men who had sex with men (MSM), most of whom were between the ages of 20 and 50 years and had occurred in a multi-country outbreak with no epidemiological link to West and/or Central Africa.…”

Section: Introductionmentioning

confidence: 99%

Temporal intra‐host variability of mpox virus genomes in multiple body tissues

Rueca

Tucci

Mazzotta

et al. 2023

Journal of Medical Virology

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Whole‐genome sequencing (WGS) has been widely used for the genomic characterization and the phylogenesis of mpox virus (MPXV) 2022 multi‐country outbreak. To date, no evidence has been reported on intra‐host evolution within samples collected over time from a single patient with long‐term infection. Fifty‐one samples were collected from five patients at different time points post‐symptom onset. All samples were confirmed as MPXV DNA positive, amplified by a multiplexed PCR amplicon, and sequenced by WGS. Complete MPXV genomes were assembled by reference mapping and then aligned to perform phylogenetic and hierarchical clustering analysis. Large intra‐host variability was observed among the MPXV genomes sequenced from samples of two immunocompromised with advanced HIV‐1 infection patients with prolonged MPXV shedding. Overall, 20 nucleotide mutations were identified in the 32 genomes from HIV patients, differently distributed in samples collected from different tissues and at different time points. No sequence compartmentalization nor variation was observed in the three patients with rapid viral clearance. MPXV exhibits adaptation to changing environments within the infected host and consequently demonstrates tissue compartmentalization. Further studies are needed to elucidate the role of this adaptation in forming a pool of genetic variability and contributing to viral persistence and its clinical implications.

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Section: Introductionmentioning

confidence: 99%

Temporal intra‐host variability of mpox virus genomes in multiple body tissues

Rueca

Tucci

Mazzotta

et al. 2023

Journal of Medical Virology

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“…1,2 Recently, the World Health Organisation responded to concerns of social stigma and discrimination by recommending to change the name of the infection to Mpox. 3 Mpox (MPX) circulated in West and Central Africa with small, short-lived outbreaks outside of Africa. 4,5 Starting in May of 2022, a global outbreak of MPX was reported, which grew to over 85,765 cases in 110 countries, as of February 13, 2023.…”

Section: Conflict Of Interest : Nonementioning

confidence: 99%

Mpox in the New York Metropolitan area, Summer 2022

Keller

Gnanaprakasam

Glassman

et al. 2023

Preprint

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Early in the 2022 Mpox (MPX) global outbreak, caseloads in the New York Metropolitan area climbed rapidly before other US urban areas. This case series summarizes the authors’ clinical experience detecting and treating MPX, during a quickly evolving outbreak. Clinical outcomes were recorded with a focus on varied clinical presentation and outcomes such as complications and response to experimental tecovirimat therapy. A focal or multifocal rash was the most common presenting symptom in 91% of patients. Almost two thirds (62%) of patients had anogenital involvement. Proctitis was one of the most painful presentations with 75% requiring antiviral treatment and 3 patients needing hospitalization for pain management. Most patients responded promptly to antiviral treatment with tecovirimat. Five out of 10 patients treated with tecovirimat reported symptom resolution within 48 – 72 hours of therapy and another 3 saw resolution within first 96 hours. Two patients had poor response to tecovirimat. This series includes the only reported case of an HIV positive, immunocompetent patient who experienced recurrent anal ulcers due to Mpox and required a second course of tecovirimat. Other unique presentations included urethritis, abscess formation and MPX infection post-vaccination. Control of this current Mpox outbreak was possible due to timely diagnosis and the availability of both a licensed vaccine and an investigational drug.

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“…Monkeypox is a zoonotic disease caused by a double‐stranded DNA virus known as Family Poxviridae , subfamily Chordopoxvirinae , genus Orthopoxvirus , species Monkeypox virus 1,2 . Recently, the World Health Organisation responded to concerns of social stigma and discrimination by recommending to change the name of the infection to Mpox 3 . Mpox (MPX) circulated in West and Central Africa with small, short‐lived outbreaks outside of Africa 4,5 .…”

Section: Demographics N (%) Demographics N (%)mentioning

confidence: 99%

mentioning

confidence: 99%