New nitroindazole-porphyrin conjugates: Synthesis, characterization and antibacterial properties

Eddahmi, Mohammed; Sousa, Vera; Moura, Nuno M. M.; Dias, Cristina J.; Bouissane, Latifa; Faustino, Maria A. F.; Cavaleiro, José A. S.; Gomes, Ana T. P. C.; Almeida, Adelaide; Neves, Maria G. P. M. S.; Rakib, El Mostapha

doi:10.1016/j.bioorg.2020.103994

Cited by 4 publications

(2 citation statements)

References 64 publications

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“…Our interest is centered on the functionalization of β-pyrrolic positions of meso -tetraarylporphyrins aiming to prepare new porphyrinic derivatives with adequate properties to be used in different fields [ 57 ], namely as photosensitizers in Photodynamic Therapy (PDT) or antimicrobial PDT [ 13 , 58 , 59 , 60 , 61 , 62 , 63 , 64 ]. We then report here an efficient synthetic approach to obtain a novel series of mononuclear heteroleptic porphyrin-iridium(III) complexes 4 and 5 via porphyrin derivatives 2 bearing a bipyridine unit (see Scheme 1 and Scheme 2 ).…”

Section: Introductionmentioning

confidence: 99%

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New Bis-Cyclometalated Iridium(III) Complexes with β-Substituted Porphyrin-Arylbipyridine as the Ancillary Ligand: Electrochemical and Photophysical Insights

Moura

Serra

Bastos

et al. 2022

IJMS

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An efficient synthetic access to new cationic porphyrin-bipyridine iridium(III) bis-cyclometalated complexes was developed. These porphyrins bearing arylbipyridine moieties at β-pyrrolic positions coordinated with iridium(III), and the corresponding Zn(II) porphyrin complexes were spectroscopically, electrochemically, and electronically characterized. The features displayed by the new cyclometalated porphyrin-bipyridine iridium(III) complexes, namely photoinduced electron transfer process (PET), and a remarkable efficiency to generate 1O2, allowing us to envisage new challenges and opportunities for their applications in several fields, such as photo(catalysis) and photodynamic therapies.

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Section: Introductionmentioning

confidence: 99%

“…, and H-4 C ), 6.76-6.64 (4H, m, H-5 C , H-5 F , H-4 E , and H-2 G , 6 G ), 6 59. 6.53 (2H, m, H-5 E , and H-4 D ), 6.29 (1H, td, J = 7.6 and 1.2 Hz, H-5 D ), 6.00 (1H, d, J = 7.5 Hz, H-6 C ), 5.85 (1H, d, J = 7.1 Hz, 6 E ), 5.48 (1H, d, J = 7.4 Hz, H-6 D ) ppm.…”

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confidence: 99%

New Bis-Cyclometalated Iridium(III) Complexes with β-Substituted Porphyrin-Arylbipyridine as the Ancillary Ligand: Electrochemical and Photophysical Insights

Moura

Serra

Bastos

et al. 2022

IJMS

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Study of N‐methyl‐5‐nitroindazolylacrylonitriles as a Function of Quantum Parameters Employing Density Function Theory Methods: Comparative Theoretical Study and Nonlinear Optical Properties

et al. 2023

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The synthesis of N-methyl-5-nitroindazolylacrylonitriles 2 a-l by a Knoevenagel condensation reaction with a series of aldehydes in the presence of piperidine allowed the preparation of the desired products the yields are good to excellent. N-Methyl-5-nitroindazolylacrylonitriles (2 a-l) were verified by 1 H, 13 C NMR and mass spectrometry. In this current work, the reactivity indices defined within the Conceptual DFT of the targeted molecules through DFT/B3LYP/6-311G(d,p) calculations were studied. The 1 H NMR, UV-vis and IR spectroscopy chemical shifts of all synthesized 5-nitroindazoles 2 a-l were calculated and the results were compared to the results of the experimental data. In this series of compounds, the 2 e has the lowest hyperpolarizability, which results being the most stable and having the least response to nonlinear optics (NLO). In contrast, the compound 2 l has the highest hyperpolarizability, which fallouts being the least stable and having a high response to NLO. Every chemical has a significant threedimensional p-electronic delocalization, which is crucial for understanding NLO responses.

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A Tris-Aldehyde Porphyrin Synthon: Synthesis and Characterization of 5,10,15-tris-(4’-(4-Formylphenoxy) propoxyphenyl)-20-(4-nitrophenyl)-porphyrin

Sharma

Sengupta

2023

Organic Preparations and Procedures International

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New nitroindazole-porphyrin conjugates: Synthesis, characterization and antibacterial properties

Cited by 4 publications

References 64 publications

New Bis-Cyclometalated Iridium(III) Complexes with β-Substituted Porphyrin-Arylbipyridine as the Ancillary Ligand: Electrochemical and Photophysical Insights

New Bis-Cyclometalated Iridium(III) Complexes with β-Substituted Porphyrin-Arylbipyridine as the Ancillary Ligand: Electrochemical and Photophysical Insights

Study of N‐methyl‐5‐nitroindazolylacrylonitriles as a Function of Quantum Parameters Employing Density Function Theory Methods: Comparative Theoretical Study and Nonlinear Optical Properties

A Tris-Aldehyde Porphyrin Synthon: Synthesis and Characterization of 5,10,15-tris-(4’-(4-Formylphenoxy) propoxyphenyl)-20-(4-nitrophenyl)-porphyrin

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