New Natural Marine Antacid Drug from Cuttlebone

Abstract

Background: Antacids are the most commonly used medications for fast symptomatic relief of gastric disorders. Because of adverse effects, low efficiency and the high cost of some chemical antacids, identifying a natural medicine with high efficiency and low cost seems useful. Therefore, the aim of the present study was to prepare antacid tablets from Cuttlefish bone and assessment of its antacid properties. Methods: 24 different formulations of cuttlefish bone were prepared by direct compression using different fillers (starch, cellulose, lactose, and mixture of those) in different ratios of the drug. Characterization of powders and tablets was done on all formulations and marketed dosage forms (calcium carbonate and Al-Mg). Results: Weight uniformity, hardness, and friability of all formulations were in acceptable range. Tablets prepared by calcined cuttlebone disintegrated in longer time due to their higher hardness which were mostly higher than 5 Kg. Also, disintegration time of formulations 50-50 (lower dose of cuttlebone) was less than other tablets (2 minutes or less). Results of antacid capacity showed that formulations 90-10 and 80-20 raise the acidic pH of the medium above 7.5, which were the same as or more than the capacity of the marketed tablets.

Polymer composites for medical applications as artificial bones

“…Figure 10 shows that the Rockwell hardness increases as a function of the calcium carbonate content, which is a typical behavior for fillers [41]. Moreover, the addition of the hybrid filler causes a decrease in hardness, which, however, increases slightly as the filling increases.…”

The safety and efficacy of Houtou Jianweiling tablet in patients with chronic non-atrophic gastritis: a double-blind, non-inferiority, randomized controlled trial

“…The HTJWT is composed of six ingredients including H. mycelium , Cuttlebone , Vinegar Rhizoma Corydalis , Paeonia Lactiflora ( Jiubaishao ), Vinegar Xiangfu , and Glycyrrhiza . All the ingredients of the HTJWT have definite therapeutic effects to regulates Qi, relieve abdominal pain, abdominal distension, vomiting, acid reflux, bloating and belching while controlling liver-stomach coordination ( Tan et al, 2023 ) however, H. mycelium is the main ingredient of the formulation for treating CNAG ( Liu et al, 1990 ; Ou-Yang, 2008 ; He and Dai, 2011 ; Rahnama et al, 2013 ; Thomas et al, 2015 ; Wang et al, 2017 ; Mostoufi et al, 2018 ). The purpose of this trial was to offer scientific evidence that this TCM can be used as an alternative for the treatment of CNAG.…”

“…After clinical verification, the total significant efficiency and total effective rate of the HTJWT in treating CNAG caused by disharmony between the liver and stomach were 63.95% and 89.83%, respectively. Hericium mycelium along with five TCMs are considered to be vitally important to treat CNAG caused by disharmony between liver and stomach ( Liu et al, 1990 ; Wang et al, 2017 ; Mostoufi et al, 2018 ).…”

The Use of Shells of Marine Molluscs in Spanish Ethnomedicine: A Historical Approach and Present and Future Perspectives

“…Prepared formulations from cuttlebone showed appropriate physicochemical properties and high antacid capacity. Then, as proposed by Mostoufi et al [123], we can use formulations of cuttlefish bone as a good natural antacid drug that has fewer side effects, has high efficiency, is inexpensive, and is comparable with the marketed tablets and other antacid compounds.…”