New nanohybrid materials for biophotonics

Sajti, Csaba Lảszlỏ; Giorgio, S.; Khodorkovsky, Vladimir; Marine, W.

doi:10.1007/s00339-007-4137-z

Cited by 15 publications

(8 citation statements)

References 11 publications

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“…The ZnO NPs in ethanol were prepared by laser ablation according to [14]. The typical NP size was 17 nm with the dispersion about 25%.…”

Section: Resultsmentioning

confidence: 99%

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Synthesis and spectroscopic properties of 4-amino-1,8-naphthalimide derivatives involving the carboxylic group: a new molecular probe for ZnO nanoparticles with unusual fluorescence features

Bekere¹,

Gachet²,

Lokshin³

et al. 2013

Beilstein J. Org. Chem.

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SummaryOf a series of 4-substituted 1,8-naphthalimides, fluorescent 4-(6-piperidinyl-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)benzoic acid (4) was found to be a sensitive molecular probe for ZnO nanoparticles. We investigated in detail one- and two-photon absorption properties of this fluorophore. In nonpolar solvents, the acid 4 absorbs at about 400 nm and fluoresces at 500 nm with a fluorescence lifetime of about 7 ns, similar to the ester 6 and typical of the lifetimes of other derivatives of this type. Although the anionic form of this acid is not fluorescent, partial ionization of 4 in polar solvents, such as ethanol and acetonitrile, is not only accompanied by the expected decrease in the fluorescence quantum yield, but also gives rise to bathochromic shifts of both absorption and fluorescence and dual fluorescence with lifetimes of 0.2–0.3 ns and 6 ns ascribed to the formation of anionic complexes. The interaction with the ZnO surface brings about further considerable changes in the fluorescence patterns.

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“…The ZnO NPs in ethanol were prepared by laser ablation according to [14]. The typical NP size was 17 nm with the dispersion about 25%.…”

Section: Resultsmentioning

confidence: 99%

“…The phenyl moiety can serve as a rigid spacer, while the carboxylic group can function as an anchor for grafting the fluorophore to metal oxide surfaces. This approach to the modification of ZnO nanoparticles produced by femtosecond laser ablation was demonstrated to afford nanohybrid materials for biophotonic applications [13–14]. …”

Section: Introductionmentioning

confidence: 99%

Synthesis and spectroscopic properties of 4-amino-1,8-naphthalimide derivatives involving the carboxylic group: a new molecular probe for ZnO nanoparticles with unusual fluorescence features

Bekere¹,

Gachet²,

Lokshin³

et al. 2013

Beilstein J. Org. Chem.

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“…During the past decade, the pulsed laser ablation process has been shown to be a promising technique for chemically pure synthesis of nanoparticles (NPs) in liquid solutions. − Among the advantages of this method, we can mention the simplicity of the experimental setup, the possibility of synthesis of various materials ranging from metallic and semiconductor NPs to more complex materials , and rather complicated structures, such as core−shell NPs . In addition, laser pulses can be also used to fragment, reshape, and conjugate NPs. − Under carefully chosen experimental conditions, the stability of the obtained colloidal solutions can be very high, so that the NPs can be used for many applications in such fields as medicine, sensing, electronics, optics, and biophotonics.…”

Section: Introductionmentioning

confidence: 99%

“…During the past decade, the pulsed laser ablation process has been shown to be a promising technique for chemically pure synthesis of nanoparticles (NPs) in liquid solutions. [1][2][3][4] Among the advantages of this method, we can mention the simplicity of the experimental setup, the possibility of synthesis of various materials ranging from metallic 5 and semiconductor NPs 6 to more complex materials 7,8 and rather complicated structures, such as core-shell NPs. 9 In addition, laser pulses can be also used to fragment, reshape, and conjugate NPs.…”

Section: Introductionmentioning

confidence: 99%

On Nanoparticle Formation by Laser Ablation in Liquids

Itina

2010

J. Phys. Chem. C

143

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Nanoparticle formation by laser ablation in liquids is studied numerically. We investigate such processes as cluster ejection, cluster nucleation, and aggregation. First, laser plume formation, its expansion, and confinement by the liquid are considered. These processes are connected with the formation of two shock waves: one moving inside the solid and the second one propagating in the liquid. If short and ultrashort laser pulses are used, the created plasma plume does not absorb laser radiation. In this case, a larger energy fraction is transferred into the solid during much shorter time, so that the ablation process is explosive. As a result, cluster precursors are ejected directly from the target, and the created plasma is confined to a smaller volume. Shorter laser pulses thus provide more favorable conditions for nanoparticle formation. In addition to the following short plasma expansion stage, a much longer aggregation process occurring in the liquid phase is found to affect the final size distribution.

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“…Our study demonstrates that a set of measures at different levels of care provide a signi cant economic bene t. It should be noted that the potential bene ts of the implementation of this type of programme include not only a reduction in the number of ED revisits to the emergency room, but also an improvement in the quality of life of patients. Several studies have shown an improvement in the quality of life with an intervention programme for chronic treatments [14][15][16][17], which is a bene t to be considered after the investment made. However, the results of the clinical trial did not include this aspect in this group of patients, not allowing to perform a quality-adjusted year's analysis.…”

Section: Discussionmentioning

confidence: 99%

Cost-Effectiveness Analysis of Implementing a Secondary Prevention Programme in Those Patients Who Visited an Emergency Department for Drug-Related Problems

Ruiz

Juanes‐Borrego

Puig

et al. 2021

Preprint

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Background: To evaluate the cost-effectiveness of a secondary prevention programme in patients admitted to the Emergency department due drug-related problems (DRPs) Methods: A decision model compared costs and outcomes of patients admitted to the Emergency department with drug-related problems included in Anatomical Therapeutic Classification (ATC) groups A, B or C was designed, based on the results of a randomized clinical trial (NCT03607097). Model variables and costs, along with their distributions, were obtained from the trial results and the literature. The study was performed from the perspective of the National Health System including only direct costs. The Incremental Cost-Effectiveness ratio (ICER) was analysed regarding the ability of the programme to reduce emergency department revisits. Uncertainty in ICERs was evaluated with probabilistic sensitivity analyses. Results: According to the results of the proposed model, the implementation of a secondary prevention programme for DRPs reduces the cost associated with Emergency Department revisits, with an annual net benefit of €87,639. Considering a mortality rate attributable to readmission for DRPs of 4.7%, the cost per life-years gained (LYG) with the implementation of this program was €2,205. In the short term, the reduction in the number of revisits due to the implementation of the programme was the variable that most affected the model, with the benefit threshold value corresponding to a relative reduction of 12.4% of the number of revisits in patients with DRPs to obtain benefits with the implementation of this type of programme. Conclusions: Implementing a secondary prevention programme is cost-effective on patients admitted to the emergency department with DRPs. Implementation costs will be exceeded by reducing revisits to the emergency department.

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New nanohybrid materials for biophotonics

Cited by 15 publications

References 11 publications

Synthesis and spectroscopic properties of 4-amino-1,8-naphthalimide derivatives involving the carboxylic group: a new molecular probe for ZnO nanoparticles with unusual fluorescence features

Synthesis and spectroscopic properties of 4-amino-1,8-naphthalimide derivatives involving the carboxylic group: a new molecular probe for ZnO nanoparticles with unusual fluorescence features

On Nanoparticle Formation by Laser Ablation in Liquids

Cost-Effectiveness Analysis of Implementing a Secondary Prevention Programme in Those Patients Who Visited an Emergency Department for Drug-Related Problems

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