New N-terminal Fatty Acid Modified-Melittin Analogues With Potent Biological Activity
Sheng Huang,
Guoqi Su,
Shan Jiang
et al.
Abstract:Melittin, a natural antimicrobial peptide, displays a broad-spectrum antimicrobial activity, which has caused increasing attention as a potential antibiotic alternative. However, melittin has not been used widely at present due to its high hemolysis and low proteolytic stability. In this study, N-terminal fatty acid was conjugated to melittin to develop new melittin-derived lipopep-tides (MDLs) for improving the limitation of melittin. Our results showed that, the antimicrobial activity of MDLs was increased b… Show more
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