New N-substituted derivatives of the drug riluzol

Straightforward Approach Toward Dihydrothiazoles via Intramolecular Bromocyclization

“…Riluzol is known as the only drug for the suppression of amyotrophic lateral sclerosis (ALS) progress. [10] Among the molecular recognition processes based on the photophysical behaviors, [11] thiazoline-metal-based receptors have found an important place as fluorescent probe for specific anion species in biomedical studies. [12] The predominant strategy toward the thiazoline core involves dehydrative cyclization of hydroxyethyl-thioureas using HCl [13] and carbonyl-and thiocarbonyldiimidazoles.…”