New model of focal cerebral ischemia in the miniature pig

Imai, Hideki; Konno, Kenjiro; Nakamura, Mitsunobu; Shimizu, Tatsuya; Kubota, Chisato; Seki, Koji; Honda, Fumiaki; Tomizawa, Shinichiro; Tanaka, Yoshiaki; Hata, Hidekazu; Saito, Nobuhito

doi:10.1038/sj.jcbfm.9591524.0529

Cited by 15 publications

(19 citation statements)

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“…This discrepancy could be ascribed to the vascular anatomical differences between species that may affect the functional recovery of the animals. In the miniature pig, triplicated MCAs emerge from the ICA (Imai et al, 2006), suggesting the existence of a higher number of lenticulostriatal arteries. This condition may improve collateral blood flow to the IC after AChAO, thus attenuating the ischemic impact and allowing fast neurological recovery.…”

Section: Other Studies Implementing the Achaomentioning

confidence: 98%

Internal capsule stroke in the common marmoset

et al. 2015

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Section: Other Studies Implementing the Achaomentioning

confidence: 98%

Internal capsule stroke in the common marmoset

et al. 2015

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“…A variety of animal models including pigs [31] and non-human primates [32] have been explored, but rat models of stroke are by far the most common choice for researchers. This is largely due to the similar neurovascular branching to humans [33,34], relatively low cost [35], and high number of validated behavioural tests of functional outcome in the rat [33,35,36].…”

Section: Introductionmentioning

confidence: 99%

Animal models of post-ischemic forced use rehabilitation: methods, considerations, and limitations

Livingston-Thomas

Tasker

2013

Exp & Trans Stroke Med

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Many survivors of stroke experience arm impairments, which can severely impact their quality of life. Forcing use of the impaired arm appears to improve functional recovery in post-stroke hemiplegic patients, however the mechanisms underlying improved recovery remain unclear. Animal models of post-stroke rehabilitation could prove critical to investigating such mechanisms, however modeling forced use in animals has proven challenging. Potential problems associated with reported experimental models include variability between stroke methods, rehabilitation paradigms, and reported outcome measures. Herein, we provide an overview of commonly used stroke models, including advantages and disadvantages of each with respect to studying rehabilitation. We then review various forced use rehabilitation paradigms, and highlight potential difficulties and translational problems. Lastly, we discuss the variety of functional outcome measures described by experimental researchers. To conclude, we outline ongoing challenges faced by researchers, and the importance of translational communication. Many stroke patients rely critically on rehabilitation of post-stroke impairments, and continued effort toward progression of rehabilitative techniques is warranted to ensure best possible treatment of the devastating effects of stroke.

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“…First, FBI is induced by transorbital frontotemporal permanent middle cerebral artery occlusion. In this model, consistent and predictable neurodegenerative changes have been identified in affected brain regions using MRI and histopathological analysis (Imai et al, ; Zhang et al, ). Second, FBI was produced in male infant piglets (2–4 weeks old) by photothrombotic occlusion of the middle cerebral artery.…”

Section: Miniature Pig As a Disease Preclinical Modelmentioning

confidence: 89%

Pig models of neurodegenerative disorders: Utilization in cell replacement‐based preclinical safety and efficacy studies

Doležalová

Hruška-Plocháň

Bjarkam

et al. 2014

J of Comparative Neurology

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An important component for successful translation of cell replacement-based therapies into clinical practice is the utilization of large animal models to conduct efficacy and/or safety cell dosing studies. Over the past few decades, several large animal models (dog, cat, nonhuman primate) were developed and employed in cell replacement studies; however, none of these models appears to provide a readily available platform to conduct effective and large-scale preclinical studies. In recent years, numerous pig models of neurodegenerative disorders were developed using both a transgenic approach as well as invasive surgical techniques. The pig model (naïve noninjured animals) was recently used successfully to define the safety and optimal dosing of human spinal stem cells after grafting into the central nervous system (CNS) in immunosuppressed animals. The data from these studies were used in the design of a human clinical protocol used in amyotrophic lateral sclerosis (ALS) patients in a Phase I clinical trial. In addition, a highly inbred (complete major histocompatibility complex [MHC] match) strain of miniature pigs is available which permits the design of comparable MHC combinations between the donor cells and the graft recipient as used in human patients. Jointly, these studies show that the pig model can represent an effective large animal model to be used in preclinical cell replacement modeling. This review summarizes the available pig models of neurodegenerative disorders and the use of some of these models in cell replacement studies. The challenges and potential future directions in more effective use of the pig neurodegenerative models are also discussed.

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New model of focal cerebral ischemia in the miniature pig

Cited by 15 publications

References 0 publications

Internal capsule stroke in the common marmoset

Internal capsule stroke in the common marmoset

Animal models of post-ischemic forced use rehabilitation: methods, considerations, and limitations

Pig models of neurodegenerative disorders: Utilization in cell replacement‐based preclinical safety and efficacy studies

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