New Methods of Analysis and Investigation of Terpenoid Indole Alkaloids

Goldhaber-Pasillas, Guitele Dalia; Choi, Young Hae; Verpoorte, Robert

doi:10.1016/b978-0-12-408061-4.00009-2

Cited by 4 publications

(1 citation statement)

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“…Figure 24. Indole alkaloids -strychnine, brucine, asterriquinone, physostigmine, and rivastigmine [50] With methods of extraction developing since the 1960s, with many efforts concentrating on the efficiency and environmental impact of the process, terpenoid indole alkaloids and their pharmacological properties continue to attract attention as some of them are already marketed as anticancer, antihypertensive, or hypoglycemic agents, for example [52]. Some monoterpene indole alkaloids are in high demand, such as vinblastine (Catharanthus roseus) and camptothecin (Camptotheca acuminata, Nothapodytes foetida), currently used as chemotherapic drugs, and eyes have turned toward metabolic engineering.…”

Section: Natural and Synthetic Indolesmentioning

confidence: 99%

Breakthroughs in Indole and Indolizine Chemistry – New Synthetic Pathways, New Applications

Ghinea¹,

Dinică²

2016

Scope of Selective Heterocycles From Organic and Pharmaceutical Perspective

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Indole and indolizines heterocyclic aromatic compounds structurally and chemically isomeric with indoles are an important class of N-fused heterocyclic compounds due to their interesting biological and optical properties. Different strategies for generating diverse collections of small molecules with indole and indolizine moieties have been developed. They can be synthesized by means of classical and nonclassical pathways. The present study discusses the versatile nature of indole/indolizine derivatives, new green methods for their synthesis, their possible mechanism of action and also provides information about current/future prospects of the topics and different indole/indolizine derivatives in pharmaceutical/clinical trials. With the remarkable number of approved indole-containing drugs as well as the importance of the indolizine moiety, it can be easily concluded that indole and indolizine derivatives offer perspectives on how pyrrole scaffolds might be exploited in the future as bioactive molecules against a broad range of diseases.

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Section: Natural and Synthetic Indolesmentioning

confidence: 99%