New method for the synthesis of 15O-labeled carbon monoxide and 15O-labeled dioxide for rapid supply in clinical use

Miyake, Yoichi; Iida, Hidehiro; Hayashida, Kentaro; Ishida, Yoshiteru

doi:10.1016/j.ics.2004.04.060

Cited by 3 publications

(3 citation statements)

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“…An automated system, desirably combined with a dedicated cyclotron, would be the need to improve the logistics of the examination, under the concurrent operation of the radioactivity supply and the PET scanning. 28, 29 Noninvasive determination of the arterial input function without the arterial blood sampling is also a key issue for practical use of this technique. 30 Further evaluations are warranted.…”

Section: Discussionmentioning

confidence: 99%

Rapid Quantitative CBF and CMRO₂ Measurements from a Single PET Scan with Sequential Administration of Dual ¹⁵O-Labeled Tracers

Kudomi

Hirano

Koshino

et al. 2012

J Cereb Blood Flow Metab

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Positron emission tomography (PET) with 15O tracers provides essential information in patients with cerebral vascular disorders, such as cerebral blood flow (CBF), oxygen extraction fraction (OEF), and metabolic rate of oxygen (CMRO2). However, most of techniques require an additional C15O scan for compensating cerebral blood volume (CBV). We aimed to establish a technique to calculate all functional images only from a single dynamic PET scan, without losing accuracy or statistical certainties. The technique was an extension of previous dual-tracer autoradiography (DARG) approach, but based on the basis function method (DBFM), thus estimating all functional parametric images from a single session of dynamic scan acquired during the sequential administration of H215O and 15O2. Validity was tested on six monkeys by comparing global OEF by PET with those by arteriovenous blood sampling, and tested feasibility on young healthy subjects. The mean DBFM-derived global OEF was 0.57±0.06 in monkeys, in an agreement with that by the arteriovenous method (0.54±0.06). Image quality was similar and no significant differences were seen from DARG; 3.57%±6.44% and 3.84%±3.42% for CBF, and −2.79%±11.2% and −6.68%±10.5% for CMRO2. A simulation study demonstrated similar error propagation between DBFM and DARG. The DBFM method enables accurate assessment of CBF and CMRO2 without additional CBV scan within significantly shortened examination period, in clinical settings.

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Section: Discussionmentioning

confidence: 99%

Rapid Quantitative CBF and CMRO₂ Measurements from a Single PET Scan with Sequential Administration of Dual ¹⁵O-Labeled Tracers

Kudomi

Hirano

Koshino

et al. 2012

J Cereb Blood Flow Metab

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“…The limitation is due to the need for a sequential supply of two radioactive compounds, namely, 15 O 2 and C 15 O 2 , within a short interval, including radio-synthesis, quality control, and purity examination before administration. An automated synthesis system able to operate under the same operation system as for the 15 O-dedicated cyclotron would help to improve the logistics necessary in the procedures [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Applicability of emission-based attenuation map for rapid CBF, OEF, and CMRO2 measurements using gaseous 15O-labeled compounds

et al. 2015

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BackgroundCerebral blood flow (CBF), oxygen extraction fraction (OEF), and cerebral metabolic rate of oxygen (CMRO2) images have facilitated understanding of the pathophysiological basis of cerebrovascular disorders. Such parametric images can be rapidly, measured within around 15 min, using positron emission tomography (PET) with sequentially administered 15O-labeled oxygen and water. For further shortening, one option is to eliminate the transmission scan by applying an emission-based attenuation correction.MethodsThe validity of the present method was tested by comparing parametric values with emission-based attenuation correction to those with transmission-based correction. This was applied to 27 subjects who were diagnosed with or without cerebrovascular disorders. All subjects received the rapid CBF/OEF/CMRO2 PET measurements. An emission-based attenuation map was generated by estimating the edge of the brain tissue contour on an obtained sinogram and by assuming the uniform tissue coefficient to be 0.1 cm−1. Then images were reconstructed, and parametric images were computed.ResultsNo difference was apparent between the emission- and transmission-based methods. Paired t-test showed no significant differences in CBF, OEF, or CMRO2 values between the emission- and transmission-based methods, except in the parietal and occipital and cerebellum and occipital regions, and the differences were less than 10%. The regression analysis showed a close correlation of r = 0.89 to 0.99.ConclusionsThe present study revealed that the attenuation correction can be performed by the emission-based estimation method and clinical PET duration can be shortened for the CBF, OEF, and CMRO2 gas study.

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“…The most common tracers used for measuring oxygen consumption and blood volume are [ 15 O]O 2 and [ 15 O]CO, respectively (1–4). In general, these oxygen‐15 labelled tracers are produced using a cyclotron that accelerates deuterons onto a target filled with [ 14 N]N 2 containing a trace of oxygen (5–8). In recent years, cyclotrons have been developed that are capable of accelerating protons.…”

Section: Introductionmentioning

confidence: 99%

Pharmaceutical preparation of oxygen-15 labelled molecular oxygen and carbon monoxide gasses in a hospital setting

Luurtsema¹,

Boellaard²,

Greuter³

et al. 2010

Journal of Clinical Pharmacy and Therapeutics

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New method for the synthesis of 15O-labeled carbon monoxide and 15O-labeled dioxide for rapid supply in clinical use

Cited by 3 publications

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Rapid Quantitative CBF and CMRO₂ Measurements from a Single PET Scan with Sequential Administration of Dual ¹⁵O-Labeled Tracers

Rapid Quantitative CBF and CMRO₂ Measurements from a Single PET Scan with Sequential Administration of Dual ¹⁵O-Labeled Tracers

Applicability of emission-based attenuation map for rapid CBF, OEF, and CMRO2 measurements using gaseous 15O-labeled compounds

Pharmaceutical preparation of oxygen-15 labelled molecular oxygen and carbon monoxide gasses in a hospital setting

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New method for the synthesis of 15O-labeled carbon monoxide and 15O-labeled dioxide for rapid supply in clinical use

Cited by 3 publications

References 1 publication

Rapid Quantitative CBF and CMRO2 Measurements from a Single PET Scan with Sequential Administration of Dual 15O-Labeled Tracers

Rapid Quantitative CBF and CMRO2 Measurements from a Single PET Scan with Sequential Administration of Dual 15O-Labeled Tracers

Applicability of emission-based attenuation map for rapid CBF, OEF, and CMRO2 measurements using gaseous 15O-labeled compounds

Pharmaceutical preparation of oxygen-15 labelled molecular oxygen and carbon monoxide gasses in a hospital setting

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Rapid Quantitative CBF and CMRO₂ Measurements from a Single PET Scan with Sequential Administration of Dual ¹⁵O-Labeled Tracers

Rapid Quantitative CBF and CMRO₂ Measurements from a Single PET Scan with Sequential Administration of Dual ¹⁵O-Labeled Tracers