New method for the determination of parabens and bisphenol A in human milk samples using ultrasound-assisted extraction and clean-up with dispersive sorbents prior to UHPLC–MS/MS analysis

Rodríguez-Gómez, R.; Dorival-García, Noemí; Zafra-Gómez, A.; Camino-Sánchez, F.J.; Ballesteros, O.

doi:10.1016/j.jchromb.2015.04.022

Cited by 41 publications

(13 citation statements)

References 41 publications

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“…Methyl para ‐hydroxybenzoate has a number of practical applications, eg, as a food preservative (it is called methylparaben and is coded under the number E218). ESI‐MS coupled with liquid chromatography, usually in negative ion mode, has been used for its analysis in various samples . Methyl ortho ‐hydroxybenzoate (methyl salicylate) has been found in various natural sources usually by using EI mass spectrometry coupled with gas chromatography .…”

Section: Resultsmentioning

confidence: 99%

“…ESI-MS coupled with liquid chromatography, usually in negative ion mode, has been used for its analysis in various samples. [38][39][40][41][42] Methyl ortho-hydroxybenzoate (methyl salicylate) has been found in various natural sources usually by using EI mass spectrometry coupled with gas chromatography. [43][44][45][46] It is worth adding that EI mass spectra of all methyl hydroxybenzoate isomers are very similar (http://webbook.nist.gov/chemistry/), which may cause a problem with their correct identification.…”

Section: Introductionmentioning

confidence: 99%

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Methyl group transfer upon gas phase decomposition of protonated methyl benzoate and similar compounds

et al. 2018

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Gas phase decompositions of protonated methyl benzoate and its conjugates have been studied by using electrospray ionization-collision induced dissociation-tandem mass spectrometry. Loss of CO molecule, thus transfer of methyl group, has been observed. In order to better understand this process, the theoretical calculations have been performed. For methyl benzoate conjugates, it has been found that position of substituent affects the loss of CO molecule, not the electron donor/withdrawing properties of the substituent. Therefore, electrospray ionization-mass spectrometry in positive ion mode may be useful for differentiation of isomers of methyl benzoate conjugates.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Methyl group transfer upon gas phase decomposition of protonated methyl benzoate and similar compounds

et al. 2018

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“…The concentration range of parabens in breast milk determined in this study agreed with data of a previous study by our group, 9 conducted with 16 lactating mothers in Brazil. Using different sample preparation techniques, Rodríguez-Gómez et al 7,8,33,34 developed analytical methods and determined parabens in human milk samples with concentrations ranging from 0.1 to 7.5 ng mL -1 , 0.5 to 37.0 ng mL -1 , 0.6 to 43.5 ng mL -1 and 1.02 to 18.1 ng mL -1 , respectively. Studies also conducted in Spain [37][38][39] determined parabens in a range from 0.12 to 8.1 ng mL -1 , 0.9 to 21 ng mL -1 and from 0.7 to 18.6 ng mL -1 , respectively.…”

Section: Concentration Of Parabens In Breast Milk Samples From Voluntmentioning

confidence: 99%

Determination of Parabens in Breast Milk Samples by Dispersive Liquid-Liquid Microextraction (DLLME) and Ultra-High-Performance Liquid Chromatography Tandem Mass Spectrometry

Grecco¹,

Souza²,

Acquaro³

et al. 2018

J. Braz. Chem. Soc.

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A reliable method was developed and validated based on dispersive liquid-liquid microextraction (DLLME) and ultra-high-performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS) to determine simultaneously methylparaben (MePB), ethylparaben (EtPB), propylparaben (PrPB), and butylparaben (BuPB) in breast milk samples. A central composite design 2 4 with four independent variables and five levels of variance was used to optimize the DLLME conditions. The DLLME/UHPLC-MS/MS method was linear from 5 (lower limit of quantification, LLOQ) to 100 ng mL -1 (upper limit of quantification, ULOQ). The inter-assay and intra-assay precision values presented coefficients of variation (CVs) lower than 15%, and the relative standard error of the inter-and intra-assay accuracy values was lower than 10.4%. The DLLME/UHPLC-MS/MS method was successfully applied to determine parabens in human milk samples obtained from sixteen volunteer lactating mothers.

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“…For the multiresidue analysis of either benzophenone or parabens and bisphenol A, ultrasound-assisted extraction, followed by a clean-up step with dispersive-SPE sorbents (PSA, C18) has been recently published [98,99].…”

Section: Ms/msmentioning

confidence: 99%

Bioanalytical challenge: A review of environmental and pharmaceuticals contaminants in human milk

Lopes

Barreiro

Cass

2016

Journal of Pharmaceutical and Biomedical Analysis

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New method for the determination of parabens and bisphenol A in human milk samples using ultrasound-assisted extraction and clean-up with dispersive sorbents prior to UHPLC–MS/MS analysis

Cited by 41 publications

References 41 publications

Methyl group transfer upon gas phase decomposition of protonated methyl benzoate and similar compounds

Methyl group transfer upon gas phase decomposition of protonated methyl benzoate and similar compounds

Determination of Parabens in Breast Milk Samples by Dispersive Liquid-Liquid Microextraction (DLLME) and Ultra-High-Performance Liquid Chromatography Tandem Mass Spectrometry

Bioanalytical challenge: A review of environmental and pharmaceuticals contaminants in human milk

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