New method for production of 155Tb via 155Dy by irradiation of natGd by medium energy alpha particles

Moiseeva, A. N.; Алиев, Р. А.; Furkina, E. B.; Новиков, В. И.; Унежев, В. Н.

doi:10.1016/j.nucmedbio.2021.12.004

Cited by 12 publications

(6 citation statements)

References 24 publications

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“…The main drawback of these methods is the need for highly enriched (close to 100%) gadolinium-155 targets in order to produce terbium-155 with sufficient radionuclide purity. Recently, an indirect production route via dysprosium-155 was developed by Moiseeva et al enabling the production of terbium-155 with acceptable radionuclide purity without the need for highly enriched Gd targets 38 . The primary impurity is terbium-153 (T 1/2 = 2.34 days, E β+,av = 547.41 keV, I β+ = 100%), constituting less than 5.4% of the terbium-155 activity.…”

Section: Radionuclide Properties and Production Methods Of The Four C...mentioning

confidence: 99%

“…Though the impact is expected to be small, additional research is needed to fully understand the potential effects of this radionuclidic impurity on the body. Notably the use of enriched targets will further improve the yield of terbium-155 and reduce the impurities [38]. In a similar manner, the production of terbium-155 through the irradiation of dysprosium targets with α-particles, protons, or deuterons was investigated [39][40][41].…”

Section: Terbium-155mentioning

confidence: 99%

See 1 more Smart Citation

Terbium radionuclides for theranostic applications in nuclear medicine: from atom to bedside

Van Laere,

Koole,

Deroose

et al. 2024

Theranostics

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Terbium features four clinically interesting radionuclides for application in nuclear medicine: terbium-149, terbium-152, terbium-155, and terbium-161. Their identical chemical properties enable the synthesis of radiopharmaceuticals with the same pharmacokinetic character, while their distinctive decay characteristics make them valuable for both imaging and therapeutic applications. In particular, terbium-152 and terbium-155 are useful candidates for positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging, respectively; whereas terbium-149 and terbium-161 find application in α- and β - -/Auger electron therapy, respectively. This unique characteristic makes the terbium family ideal for the “matched-pair” principle of theranostics. In this review, the advantages and challenges of terbium-based radiopharmaceuticals are discussed, covering the entire chain from radionuclide production to bedside administration. It elaborates on the fundamental properties of terbium, the production routes of the four interesting radionuclides and gives an overview of the available bifunctional chelators. Finally, we discuss the preclinical and clinical studies as well as the prospects of this promising development in nuclear medicine.

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Section: Radionuclide Properties and Production Methods Of The Four C...mentioning

confidence: 99%

Section: Terbium-155mentioning

confidence: 99%

Terbium radionuclides for theranostic applications in nuclear medicine: from atom to bedside

Van Laere,

Koole,

Deroose

et al. 2024

Theranostics

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“…The curve obtained in this work is referred to as "TALYS modified" and is represented in Fig. 1 both for the reaction with protons and α particles, in comparison with the standard TENDL calculations and with the experimental data [6], [7], [18][19][20].…”

Section: Cross Section Analysismentioning

confidence: 99%

“…A study of the generator system 155 Dy/ 155 Tb was performed experimentally by Steyn et al [6] and by Moiseeva et al [7] for the reactions with protons and α particles respectively, providing a first estimation of activities and purities. Nevertheless, new investigations are necessary to identify the optimal conditions for the production of 155 Tb with high purity: a better description of the cross sections has to be achieved and the number of produced nuclides have to be carefully evaluated, taking into account the radioactive decay chains and also optimizing the timings for the two radiochemical separations.…”

Section: Introductionmentioning

confidence: 99%

¹⁵⁵Tb from natural targets: Reaction modeling of ^natTb(p, x) and ^natGd(α, x)

Colombi,

Fontana,

Carante

2024

EPJ Web Conf.

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Four terbium radionuclides (149Tb, 152Tb, 155Tb and 161Tb) are promising key players in the field of radiopharmaceutical production: in particular 155Tb emits Auger-electrons and γ rays suitable respectively for therapy and for SPECT imaging. In this work we investigate and compare two 155Tb generators by considering reactions of protons on natTb and of alpha particles on natGd for energies E<70 MeV. Both routes can be studied using intermediate energy cyclotrons for the production of 155Dy, the precursor of 155Tb. The two production routes are analyzed with the nuclear reaction code TALYS by varying the parameters of the models to improve the agreement between the calculated cross sections and the available experimental data. Realistic theoretical simulations for the production of 155Tb are performed by optimizing the activity and the purity of the final product, with a full simulation of the radiochemical separation procedure.

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“…The accordance of the simulation performed with TALYS 1.96 is low. Moiseeva et al [29] demonstrated that 155 Dy can be employed as a generator for 155 Tb. However, this production pathway ( nat Dy+d) gives rise to the co-production of other radioisotopes of Dy as 157 Dy that decays with a similar half-life (8.14 h) producing 157 Tb, and this would result in a low specific activity of the eluted solution.…”

Section: Nat Dy(dx) 155 Tb(cum)mentioning

confidence: 99%

Excitation functions of deuteron induced nuclear reactions on dysprosium targets for the production of the theranostic relevant isotopes of terbium

et al. 2022

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The physical properties of $${}^{149,152,155,161}$$ 149 , 152 , 155 , 161 Tb enable their use in both diagnostic and therapeutic applications in the field of nuclear medicine. For this reason the optimization of the production routes of these radionuclides is of widespread interest in research. In this work, the feasibility of the production of $${}^{155}$$ 155 Tb and $${}^{161}$$ 161 Tb via the nuclear reactions induced by deuterons on dysprosium target with natural isotopic abundances has been discussed. The cross sections of $${}^{nat}$$ nat Dy(d,x) reactions have been studied in the 12.5–32 MeV energetic range with the stacked-foil technique and the corresponding Thick Target Yields have been obtained. The presence of terbium and dysprosium contaminants ($${}^{156,160}$$ 156 , 160 Tb, $${}^{155,157,159}$$ 155 , 157 , 159 Dy) has been evaluated too.

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New method for production of 155Tb via 155Dy by irradiation of natGd by medium energy alpha particles

Cited by 12 publications

References 24 publications

Terbium radionuclides for theranostic applications in nuclear medicine: from atom to bedside

Terbium radionuclides for theranostic applications in nuclear medicine: from atom to bedside

¹⁵⁵Tb from natural targets: Reaction modeling of ^natTb(p, x) and ^natGd(α, x)

Excitation functions of deuteron induced nuclear reactions on dysprosium targets for the production of the theranostic relevant isotopes of terbium

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New method for production of 155Tb via 155Dy by irradiation of natGd by medium energy alpha particles

Cited by 12 publications

References 24 publications

Terbium radionuclides for theranostic applications in nuclear medicine: from atom to bedside

Terbium radionuclides for theranostic applications in nuclear medicine: from atom to bedside

155Tb from natural targets: Reaction modeling of natTb(p, x) and natGd(α, x)

Excitation functions of deuteron induced nuclear reactions on dysprosium targets for the production of the theranostic relevant isotopes of terbium

Contact Info

Product

Resources

About

¹⁵⁵Tb from natural targets: Reaction modeling of ^natTb(p, x) and ^natGd(α, x)