New method for antibiotic release from bone cement (polymethylmethacrylate): Redefining boundaries

Carbó-Laso, Esther; Sanz-Ruíz, Pablo; Real, J. C. del; Ballesteros, Yolanda; Paz, E.; Arán-Aı́s, Francisca; Sánchez-Navarro, M.; Pérez-Limiñana, M.A.; López-Torres, Irene Isabel; Vaquero-Martín, Javier

doi:10.1016/j.recote.2017.12.005

Cited by 3 publications

(6 citation statements)

References 21 publications

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“…The antibiotic-impregnated cements remain a gold standard [ 20 , 21 ]. Among antibiotics usually applied for bone cements, are vancomycin [ 22 ], rifampicin [ 23 ], gentamycin [ 24 , 25 ], vancomycin, and gentamycin [ 26 ], cefazolin and gentamicin, and amphotericin against various bacteria and Candida biofilms [ 27 ], vancomycin, gentamycin and amphotericin [ 28 ], vancomycin, daptomycin, and tobramycin [ 29 ]. Antibiotic-loaded bone cements are effective by 20 to 84% to reduce the risk of prosthetic joint infection after implantation surgery [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of Different Nanometals Implemented in PMMA Bone Cement on Biological and Mechanical Properties

et al. 2022

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Cemented arthroplasty is a common process to fix prostheses when a patient becomes older and his/her bone quality deteriorates. The applied cements are biocompatible, can transfer loads, and dampen vibrations, but do not provide antibacterial protection. The present work is aimed at the development of cement with antibacterial effectivity achieved with the implementation of nanoparticles of different metals. The powders of Ag, Cu with particles size in a range of 10–30 nm (Cu10) and 70–100 nm (Cu70), AgCu, and Ni were added to PMMA cement. Their influence on compression strength, wettability, and antibacterial properties of cement was assessed. The surface topography of samples was examined with biological and scanning electron microscopy. The mechanical properties were determined by compression tests. A contact angle was observed with a goniometer. The biological tests included an assessment of cytotoxicity (XTT test on human cells Saos-2 line) and bacteria viability exposure (6 months). The cements with Ag and Cu nanopowders were free of bacteria. For AgCu and Ni nanoparticles, the bacterial solution became denser over time and, after 6 months, the bacteria clustered into conglomerates, creating a biofilm. All metal powders in their native form in direct contact reduce the number of eukaryotic cells. Cell viability is the least limited by Ag and Cu particles of smaller size. All samples demonstrated hydrophobic nature in the wettability test. The mechanical strength was not significantly affected by the additions of metal powders. The nanometal particles incorporated in PMMA-based bone cement can introduce long-term resistance against bacteria, not resulting in any serious deterioration of compression strength.

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Section: Introductionmentioning

confidence: 99%

Influence of Different Nanometals Implemented in PMMA Bone Cement on Biological and Mechanical Properties

et al. 2022

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“…Dry bone cement absorbs water, and water-soluble drugs are released with the random and irregular thermal motion of water molecules [45] . The factors which affect the drug release rate from the bone cement include: 1) absorption of water, surface area and porosity of bone cement, 2) nature and content of drug and 3) mixing method [46][47][48] . Faster water absorption, larger surface area and higher porosity lead to a higher drug release rate and release amount.…”

Section: Es-pmma Bone Cement Release Characteristicsmentioning

confidence: 99%

Release Characteristics of Enoxaparin Sodium Loaded Polymethylmethacrylate Bone Cement

Sun

et al. 2020

Preprint

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Background: This study aimed to prepare the polymethylmethacrylate (PMMA) bone cement release system with different concentrations of enoxaparin sodium (ES) and to investigate the release characteristics of ES after loading into the PMMA bone cement. Methods: In the experimental group, 40g Palacos®R PMMA bone cement was loaded with various amount of ES 4000, 8000, 12000, 16000, 20000, and 24000 AXaIU, respectively. The control group was not loaded with ES. Scanning electron microscopy (SEM) was used to observe the surface microstructure of the bone cement in the two groups. In the experiment group, the mold was extracted continuously with pH7.4 Tris-HCL buffer for 10 days. The extract solution was collected every day and the anti-FXa potency was measured. The experiment design and statistical analysis were conducted using a quantitative response parallel line method. Results: Under the SEM, it was observed that ES was filled in the pores of PMMA bone cement polymer structure and released from the pores after extraction. There was a burst effect of the release. The release amount of ES on the first day was 0.415, 0.858, 1.110, 1.564, 1.952 and 2.513 respectively from the six groups with various ES loading amount of 4000, 8000, 12000, 16000, 20000 and 24000 AXaIU, all reaching the peak of release on the first day. The release decreased rapidly on the next day and entered the plateau phase on the fourth day. Conclusion: PMMA bone cement can be used as a carrier to effectively release enoxaparin sodium within a short term.

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“…29 Some antibiotics, such as rifampin, have been shown to interfere with cement curing and may not be ideal for use. 5 However, new technology with alternative delivery systems, like rifampin in microencapsulating in alginate beads, may allow broader coverage of infecting organisms as greater rates of antibiotic resistance emerge. 5 Common doses of antibiotics added to cement for treatment of periprosthetic joint infection are shown in Table 1.…”

Section: Declaration Of Conflicting Interestsmentioning

confidence: 99%

“…5 However, new technology with alternative delivery systems, like rifampin in microencapsulating in alginate beads, may allow broader coverage of infecting organisms as greater rates of antibiotic resistance emerge. 5 Common doses of antibiotics added to cement for treatment of periprosthetic joint infection are shown in Table 1. There are a wide variety of published quantities of antibiotics, with the trend generally going toward higher doses.…”

Section: Declaration Of Conflicting Interestsmentioning

confidence: 99%

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What Determines the Type and Dose of Antibiotic That Is Needed to Be Added to the Cement Spacer in Patients With Infected Total Ankle Arthroplasty (TAA)?

Shakked

Lorenzo²

2019

Foot Ankle Int.

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Recommendation:We recommend tailoring the antibiotic in cement spacers to the infecting organism if it has been identified, as is typically done in total knee and hip arthroplasty. Otherwise, broad-spectrum antibiotics may be utilized. Medical comorbidities should always be considered, especially with regard to renal function and allergy profile. A thermostable antibiotic should be added to cement.Level of Evidence:Consensus.Delegate Vote:Agree: 100%, Disagree: 0%, Abstain: 0% (Unanimous, Strongest Consensus).

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New method for antibiotic release from bone cement (polymethylmethacrylate): Redefining boundaries

Cited by 3 publications

References 21 publications

Influence of Different Nanometals Implemented in PMMA Bone Cement on Biological and Mechanical Properties

Influence of Different Nanometals Implemented in PMMA Bone Cement on Biological and Mechanical Properties

Release Characteristics of Enoxaparin Sodium Loaded Polymethylmethacrylate Bone Cement

What Determines the Type and Dose of Antibiotic That Is Needed to Be Added to the Cement Spacer in Patients With Infected Total Ankle Arthroplasty (TAA)?

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