New mechanisms of disease and parasite-host interactions

Souza, Tiago Alves Jorge de; Carli, Gabriel José de; Pereira, Tiago Campos

doi:10.1016/j.mehy.2016.06.012

Cited by 2 publications

(3 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cancer development is a multistep process caused by aberrant gene expression via genetic and epigenetic mechanisms, which results in neoplastic cell initiation, promotion, and finally progression [ 298 ]. In recent years, there has been significant improvement in the knowledge of the molecular mechanisms that guide the host-parasite interaction [ 299 ], also thanks to numerous in vitro and in vivo studies [ 11 , 22 ]. This has led to a significant number of hypotheses relating to how this relationship can drive neoplastic development, and consequently to potential therapeutic targets.…”

Section: Carcinogenic Mechanismsmentioning

confidence: 99%

“…However, caution is needed when distinguishing a true neoplastic phenomenon from parasite life cycle stages based on abnormal larval proliferation, as in the enigmatic case of the fatal zoonotic tapeworm Sparganum proliferum [ 375 , 382 ]. From a broader perspective, this scenario has led to the theorization of new and unconventional interactions between host and parasite [ 299 ].…”

Section: Carcinogenic Mechanismsmentioning

confidence: 99%

See 1 more Smart Citation

Cancerogenic parasites in veterinary medicine: a narrative literature review

Fonti

Parisi

Mancianti

et al. 2023

Infect Agents Cancer

View full text Add to dashboard Cite

Parasite infection is one of the many environmental factors that can significantly contribute to carcinogenesis and is already known to be associated with a variety of malignancies in both human and veterinary medicine. However, the actual number of cancerogenic parasites and their relationship to tumor development is far from being fully understood, especially in veterinary medicine. Thus, the aim of this review is to investigate parasite-related cancers in domestic and wild animals and their burden in veterinary oncology. Spontaneous neoplasia with ascertained or putative parasite etiology in domestic and wild animals will be reviewed, and the multifarious mechanisms of protozoan and metazoan cancer induction will be discussed.

show abstract

Section: Carcinogenic Mechanismsmentioning

confidence: 99%

Section: Carcinogenic Mechanismsmentioning

confidence: 99%

Cancerogenic parasites in veterinary medicine: a narrative literature review

Fonti

Parisi

Mancianti

et al. 2023

Infect Agents Cancer

View full text Add to dashboard Cite

show abstract

“…Sparganum proliferum, a lethal zoonotic tapeworm, is a perplexing illustration of how a real neoplastic phenomenon can be separated from parasite life cycle stages based on larval growth (Conn 2016;Kikuchi et al 2021). More broadly, this hypothetical situation has given rise to the theory of new and unusual host-parasite interactions (de Souza et al 2016). Non-human ductal carcinoma has a broad molecular profile, and Veterinary Oncology identifies atypical routes of tumor transmission, such as contagious infectious malignancies in dogs, Tasmanian devils, golden hamsters, and sea urchins (Kattner et al 2021).…”

Section: Unusual Oncological Phenomena: Exploring Host-parasite Inter...mentioning

confidence: 99%

Chances of Cancer in Veterinarians Due to Zoonotic Cases

2023

IJAB

View full text Add to dashboard Cite

Zoonosis, an infectious disease transmitted from animals to humans, are inherent occupational hazard in veterinary practice. The potential correlation between the incidence of cancer and the occupational exposure of veterinarians to zoonosis has been discussed. While the risks associated with zoonotic infections have been extensively studied, there is a limited understanding of the potential long-term health consequences for veterinarians, particularly concerning cancer development. The research employs a retrospective cohort design, utilizing health records and occupational histories of veterinarians over an extended period. By analyzing data from diverse veterinary settings, including small and large animal practices, research laboratories, and wildlife rehabilitation centers, this study aims to identify patterns and trends in cancer occurrence among this unique occupational group. Furthermore, the investigation delves into specific zoonotic agents veterinarians may encounter during their professional activities, such as bacteria, viruses, and parasites, and assesses their potential carcinogenic effects. Factors such as duration of exposure, protective measures, and individual susceptibility will be considered in the analysis to provide a comprehensive evaluation of the relationship between occupational exposure to zoonotic agents and the likelihood of developing cancer. The findings of this study could have significant implications for veterinary occupational health and safety practices. Understanding the potential risks veterinarians face in their daily interactions with animals and zoonotic agents may lead to the development of targeted preventive measures, improved safety protocols, and enhanced awareness within the veterinary community. Ultimately, this research contributes to the broader conversation surrounding occupational health in veterinary medicine and highlights the importance of proactive measures to safeguard the well-being of veterinary professionals.

show abstract

New mechanisms of disease and parasite-host interactions

Cited by 2 publications

References 18 publications

Cancerogenic parasites in veterinary medicine: a narrative literature review

Cancerogenic parasites in veterinary medicine: a narrative literature review

Chances of Cancer in Veterinarians Due to Zoonotic Cases

Contact Info

Product

Resources

About