New Mechanism of the Reaction of O2¯ With H2o2: Significance for Biology

Afanasiev, I.B.; Kuprianova, N. S.; Letuchaia, A.V.

doi:10.1515/9783110866537.17

Cited by 4 publications

(1 citation statement)

References 11 publications

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“…200 nm increased with time. This absorption was ascertained to be due to hydrogen peroxide, ,, which is the product of the O 2 - disproportionation, on the basis of the similarity of this absorption to that of the AN solution containing hydrogen peroxide as well as the specific reaction of hydrogen peroxide with Ti 4+ (see the Experimental Section) . In further experiments to elucidate the mechanism of the disproportionation of O 2 - , a time-course of the absorbance at 300 nm was registered to avoid the overlapping of the absorption of O 2 - with that of hydrogen peroxide and in the case of the experiments in DMF and DMSO to prevent interference from the absorption of the solvents…”

Section: Resultsmentioning

confidence: 99%

Water-Induced Disproportionation of Superoxide Ion in Aprotic Solvents

et al. 1996

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The water-induced disproportionation of the electrogenerated superoxide ion (O2 -) in acetonitrile, dimethylformamide, and dimethyl sulfoxide media containing various concentrations of water as a Brønsted acid has been examined by UV−vis spectroscopy. Analysis of the kinetics as a function of O2 - and water concentrations and of the measurement time demonstrated that the disproportionation of O2 - by water in these media obeys a common mechanism: O2 - + H2O ⇄ HO2 • + OH- (k 1, k -1) HO2 • + O2 - → HO2 - + O2 (k 2) (HO2 •, hydroperoxyl radical; HO2 -, hydrogen peroxide anion). The solvent dependence of the obtained kinetic parameters of (k 1/k -1)k 2, k 1 and k -1/k 2 is discussed in terms of the solvation of O2 - and H2O as well as the effective acidities of H2O in different aprotic solvents.

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Section: Resultsmentioning

confidence: 99%

Water-Induced Disproportionation of Superoxide Ion in Aprotic Solvents

et al. 1996

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Involvement of reactive oxygen species in the microsomal S-oxidation of thiobenzamide

Younes

1985

Experientia

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Superoxide dismutase, catalase and methional proved capable of inhibiting the microsomal oxidation of thiobenzamide, which is most probably catalyzed by the flavin-containing monooxygenase. This indicates that excited oxygen species (e.g. X O-2,H2O2, X OH) are involved in the catalytic cycle of this enzymatic reaction. CO, which inhibits the cytochrome P-450-dependent oxygen radical formation, had no effect on the oxidation reaction, suggesting that the source of the reactive oxygen species is not the microsomal mixed-function oxidase.

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Molecular and functional aspects of superoxide dismutases

Gärtner

Weser

Biomimetic and Bioorganic Chemistry II

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New Mechanism of the Reaction of O2¯ With H2o2: Significance for Biology

Cited by 4 publications

References 11 publications

Water-Induced Disproportionation of Superoxide Ion in Aprotic Solvents

Water-Induced Disproportionation of Superoxide Ion in Aprotic Solvents

Involvement of reactive oxygen species in the microsomal S-oxidation of thiobenzamide

Molecular and functional aspects of superoxide dismutases

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