High energy γ-ray can be used in many fields, such as nuclear resonant fluorescence, nuclear medicine imaging. One of the methods to generate high-energy γ-ray is nuclear resonant reaction. The 19F (p,αγ) 16O reaction was used to generate 6.13-MeV γ-ray in this work. The angular distribution of 6.13-MeV γ-ray was measured by six LaBr3 detectors. The thick-target yield curve of 6.13-MeV γ-ray had been measured. The maximum yield was determined to be (1.85 ± 0.01) × 10−8
γ/proton, which was measured by HPGe detector and LaBr3 detector. The absolute efficiency of all the detectors was calibrated using 60 Co and 27Al (p,γ) 28Si reaction at E
p = 992 keV. The cross section and total resonant width of the reaction were determined to be 95.1±1.0 mb (1 b = 10−24 cm2) and Γ
CM = 2.21±0.22 keV, respectively.