New Matrix Compounds for the Detection of Carboxyl-Containing Nonsteroidal Anti-Inflammatory Drugs by MALDI Mass Spectrometry

Khrushcheva, M. L.; Krivosheina, M. S.; Matveeva, Maria D.; Zhilyaev, D. I.; Борисов, Р. С.

doi:10.1134/s1070427220080182

Cited by 4 publications

(4 citation statements)

References 13 publications

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“…5 The esterification of carboxyl-containing drugs is a vital approach to enhance pharmaceutical absorption, efficacy, and stability while extending the half-life. 6 Therefore, the development of new methodologies for constructing ester-containing compounds has been an active research area in organic synthesis. 7 Along this line, Chemler 8 a and Li 8 b independently reported copper( ii )-promoted aminoacyloxylation of allenylsulfonamides for the synthesis of pyrroles bearing vinyl carboxylate esters by using copper carboxylate as a carboxylate source (Scheme 1a).…”

Section: Introductionmentioning

confidence: 99%

PhI(OAc)₂-mediated aminoacyloxylation of β,γ-unsaturated hydrazones using Togni reagent II as an acyloxyl precursor

Dong-fang

et al. 2023

Org. Biomol. Chem.

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Section: Introductionmentioning

confidence: 99%

PhI(OAc)₂-mediated aminoacyloxylation of β,γ-unsaturated hydrazones using Togni reagent II as an acyloxyl precursor

Dong-fang

et al. 2023

Org. Biomol. Chem.

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“…The mass spectrometer is an analytical chemistry instrument that can be used for the separation and detection of compounds. It plays an important role in biological research, food and drug analysis, environmental monitoring, and detection of explosives. − Miniature mass spectrometers have the advantages of small size and portability, so they are generally used in field detection scenarios. − The indicators for evaluating the performance of mass spectrometers include the resolution, sensitivity, mass accuracy, scan range, and scan speed. Among them, the resolution reflects the ability of the instrument to distinguish adjacent mass-to-charge ratio ions.…”

Section: Introductionmentioning

confidence: 99%

SR-Unet: A Super-Resolution Algorithm for Ion Trap Mass Spectrometers Based on the Deep Neural Network

Ai,

Zhao,

et al. 2023

Anal. Chem.

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The mass spectrometer is an important tool for modern chemical analysis and detection. Especially, the emergence of miniature mass spectrometers has provided new tools for field analysis and detection. The resolution of a mass spectrometer reflects the ability of the instrument to discriminate between adjacent mass-to-charge ratio ions, and the higher the resolution, the better the discrimination of complex mixtures. Quadrupole ion traps are generally considered as a low-resolution mass spectrometry method, but they have gained wide attention and development in recent years because of their suitability for miniaturization and high qualitative capability. For an ion trap mass spectrometer, the mass sensitivity and resolution can be mutually constrained and need to be balanced by setting an appropriate scanning speed. In this study, a super-resolution U-net algorithm (SR-Unet) is proposed for ion trap mass spectrometry, which can estimate the possible ions from the overlapping ion peaks of low-resolution spectra and improve the equivalent resolution while ensuring sufficient sensitivity and analysis speed of the instrument. By determining the mass spectra of a linear ion trap mass spectrometer (LTQ XL) in Turbo and Normal scan modes, the same unit mass resolution as that at a scan speed of 16,667 Da/s was successfully obtained at 125,000 Da/s. Also, the experiments demonstrated that the algorithm is capable of the mass-to-charge ratio and instrument migration. SR-Unet can be migrated and applied to a miniature mass spectrometer for cruise detection of volatile organic compounds (VOCs), and the identification of VOC species in Photochemical Assessment Monitoring Stations (PAMS) was improved from 31 to 50 species with the same monitoring and analysis speed requirement. Further, super-unit mass resolution peptide detection was achieved on a miniature mass spectrometer with the help of the SR-Unet algorithm, which reduced the full width at half-maxima (FWHM) of bradykinin divalent ions (m/z 531) from 0.35 to 0.15 Da at a scan speed of 375 Da/s and improved the equivalent resolution to 3540. The proposed method provides a new idea to enhance the field mixture detection capability of miniature ion trap mass spectrometers.

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“…With high sensitivity and specificity, mass spectrometry has been widely used and plays an increasingly important role in biological research, food and drug analysis, explosives detection, etc. − Compared with the large-scale instruments used in the laboratory, the miniaturized ion trap mass spectrometer is more suitable for on-site analysis because of its portability and has attracted the attention of more and more researchers. − Unfortunately, the reduction of the volume has brought a series of negative effects on instrument performance. For example, the reduction of the ion trap size limits the capacity of ion storage, intensifies the space charge effect inside; and the reduction of the radio frequency (RF) power supply volume limits the maximum RF voltage.…”

mentioning

confidence: 99%

SWIFTSIN: A High-Resolution Ion Isolation Waveform for the Miniaturized Linear Ion Trap Mass Spectrometer by Coarse to Fine Excitation

Ding

Lu³

et al. 2023

Anal. Chem.

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To figure out the reason for the drawback of the stored waveform inverse Fourier transform (SWIFT) waveform and realize the high-resolution ion isolation on the miniaturized linear ion trap mass spectrometer, we studied the efficiency that ions can be excited under different excitation durations and amplitudes at different frequencies and compared the overlap ratios of the effective excitation frequency bandwidths of the adjacent ions. According to this, we proposed a new coarse-to-fine isolation waveform named SWIFTSIN. By superposing one or more sinusoidal waveforms on the SWIFT waveform and modulating the phases of the superposed sinusoidal waveforms, the generated SWIFTSIN waveform can achieve unit mass isolation on the miniaturized linear ion trap mass spectrometer without reducing the intensity of the target ion. The isolation ability of the SWIFTSIN waveform was verified by isolating a single isotope peak in the mixed samples.

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New Matrix Compounds for the Detection of Carboxyl-Containing Nonsteroidal Anti-Inflammatory Drugs by MALDI Mass Spectrometry

Cited by 4 publications

References 13 publications

PhI(OAc)₂-mediated aminoacyloxylation of β,γ-unsaturated hydrazones using Togni reagent II as an acyloxyl precursor

PhI(OAc)₂-mediated aminoacyloxylation of β,γ-unsaturated hydrazones using Togni reagent II as an acyloxyl precursor

SR-Unet: A Super-Resolution Algorithm for Ion Trap Mass Spectrometers Based on the Deep Neural Network

SWIFTSIN: A High-Resolution Ion Isolation Waveform for the Miniaturized Linear Ion Trap Mass Spectrometer by Coarse to Fine Excitation

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New Matrix Compounds for the Detection of Carboxyl-Containing Nonsteroidal Anti-Inflammatory Drugs by MALDI Mass Spectrometry

Cited by 4 publications

References 13 publications

PhI(OAc)2-mediated aminoacyloxylation of β,γ-unsaturated hydrazones using Togni reagent II as an acyloxyl precursor

PhI(OAc)2-mediated aminoacyloxylation of β,γ-unsaturated hydrazones using Togni reagent II as an acyloxyl precursor

SR-Unet: A Super-Resolution Algorithm for Ion Trap Mass Spectrometers Based on the Deep Neural Network

SWIFTSIN: A High-Resolution Ion Isolation Waveform for the Miniaturized Linear Ion Trap Mass Spectrometer by Coarse to Fine Excitation

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Product

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PhI(OAc)₂-mediated aminoacyloxylation of β,γ-unsaturated hydrazones using Togni reagent II as an acyloxyl precursor

PhI(OAc)₂-mediated aminoacyloxylation of β,γ-unsaturated hydrazones using Togni reagent II as an acyloxyl precursor