Abstract:The fast sodium channel (FSC) is one of the most important channels in the cardiomyocytes. It leads the activation of the cardiac action potentials and its dysfunction may leads to many severe pathologies. However, the currently widely used FSC model is not developed for mouse, and relatively outdated compared with the emerging experimental data on mouse atria, making the model less reliable in investigating the mechanisms underlying atrial arrhythmias. In this work, we intend to develop a new model for the mo… Show more
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