New materials and devices for preventing catheter-related infections

Timsit, Jean‐François; Dubois, Yohann; Minet, Clémence; Bonadona, Agnès; Lugosi, M.; Ara-Somohano, Claire; Hamidfar-Roy, Rébecca; Schwebel, Carole

doi:10.1186/2110-5820-1-34

Cited by 61 publications

(42 citation statements)

References 102 publications

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“…The majority of CLABSI prevention programs implemented over the past decade have focused on sterile insertion of central lines; further reduction in hospital-onset CLABSIs might require inclusion of improved catheter maintenance in prevention bundles. 9,[16][17][18] In addition, given the progress made in reducing CLABSIs in critical care settings, the contribution of patients in other at-risk clinical settings to the total CLABSI burden might now be comparable to inpatient critical care, 19 representing logical additional targets for focused intervention; these settings may include high-risk inpatient wards and outpatient hemodialysis centers.…”

Section: Discussionmentioning

confidence: 99%

National Estimates of Central Line–Associated Bloodstream Infections in Critical Care Patients

Wise

Scott

Baggs

et al. 2013

Infect. Control Hosp. Epidemiol.

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OBJECTIVE-Recent studies have demonstrated that central line-associated bloodstream infections (CLABSIs) are preventable through implementation of evidence-based prevention practices. Hospitals have reported CLABSI data to the Centers for Disease Control and Prevention (CDC) since the 1970s, providing an opportunity to characterize the national impact of CLABSIs over time. Our objective was to describe changes in the annual number of CLABSIs in critical care patients in the United States. DESIGN-Monte Carlo simulation. SETTING-US acute care hospitals. PATIENTS-Nonneonatal critical care patients.METHODS-We obtained administrative data on patient-days for nearly all US hospitals and applied CLABSI rates from the National Nosocomial Infections Surveillance and the National Healthcare Safety Network systems to estimate the annual number of CLABSIs in critical care patients nationally during the period 1990-2010 and the number of CLABSIs prevented since 1990.RESULTS-We estimated that there were between 462,000 and 636,000 CLABSIs in nonneonatal critical care patients in the United States during 1990-2010. CLABSI rate reductions led to between 104,000 and 198,000 fewer CLABSIs than would have occurred if rates had remained unchanged since 1990. There were 15,000 hospital-onset CLABSIs in nonneonatal critical care patients in 2010; 70% occurred in medium and large teaching hospitals.CONCLUSIONS-Substantial progress has been made in reducing the occurrence of CLABSIs in US critical care patients over the past 2 decades. The concentration of critical care CLABSIs in

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Section: Discussionmentioning

confidence: 99%

National Estimates of Central Line–Associated Bloodstream Infections in Critical Care Patients

Wise

Scott

Baggs

et al. 2013

Infect. Control Hosp. Epidemiol.

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“…Colonization of short-term CVCs (< 15-20 days) typically occurs at the catheter exit site. 8 Initially, the thrombus occurs at the point of vein penetration. However, this response occurs wherever and whenever a vein wall is damaged by an indwelling catheter.…”

Section: Introductionmentioning

confidence: 99%

Central Venous Catheter Securement: Using the Healthcare and Technology Synergy Model to Take a Closer Look

Macklin

Blackburn

2015

Journal of the Association for Vascular Access

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Proper securement provides a safe vascular access device environment for both patients and health care providers. Successful securement protects central venous catheters from several sources of failure until the end of therapy by preventing central venous catheter movement during all phases of care. Movement causes vein trauma, bacterial migration, distal tip location variation, loss of dressing integrity, and even total dislodgement. Any of these events can have serious consequences, including catheter-related bloodstream infection, thrombosis, delay of treatment, catheter replacement, and potential hemorrhage, all of which can be life-threatening events, and increase costs. We review patient issues, practice issues, and the types of securement currently used in clinical settings.

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“…Due to emerging drug resistance and declining efficacy, these compounds are often used with higher doses and in combination, e.g. chlorhexidine and silver sulfadiazine [15][16][17]. The efficacy of these antimicrobial agents on medical devices was controversial in various clinical trial results, with some results supporting [16,18] use and others contradicting this [15,19,20].…”

Section: Introductionmentioning

confidence: 99%

Surface micropattern reduces colonization and medical device-associated infections

Qiu-hua

Mettetal

et al. 2017

Journal of Medical Microbiology

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* AbstractPurpose. Surface microtopography offers a promising approach for infection control. The goal of this study was to provide evidence that micropatterned surfaces significantly reduce the potential risk of medical device-associated infections.Methodology. Micropatterned and smooth surfaces were challenged in vitro against the colonization and transference of two representative bacterial pathogens -Staphylococcus aureus and Pseudomonas aeruginosa. A percutaneous rat model was used to assess the effectiveness of the micropattern against device-associated S. aureus infections. After the percutaneous insertion of silicone rods into (healthy or immunocompromised) rats, their backs were inoculated with S. aureus. The bacterial burdens were determined in tissues under the rods and in the spleens.Results. The micropatterns reduced adherence by S. aureus (92.3 and 90.5 % reduction for flat and cylindrical surfaces, respectively), while P. aeruginosa colonization was limited by 99.9 % (flat) and 95.5 % (cylindrical). The micropatterned surfaces restricted transference by 95.1 % for S. aureus and 94.9 % for P. aeruginosa, compared to smooth surfaces. Rats with micropatterned devices had substantially fewer S. aureus in subcutaneous tissues (91 %) and spleens (88 %) compared to those with smooth ones. In a follow-up study, immunocompromised rats with micropatterned devices had significantly lower bacterial burdens on devices (99.5 and 99.9 % reduction on external and internal segments, respectively), as well as in subcutaneous tissues (97.8 %) and spleens (90.7 %) compared to those with smooth devices.Conclusion. Micropatterned surfaces exhibited significantly reduced colonization and transference in vitro, as well as lower bacterial burdens in animal models. These results indicate that introducing this micropattern onto surfaces has high potential to reduce medical device-associated infections.

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New materials and devices for preventing catheter-related infections

Cited by 61 publications

References 102 publications

National Estimates of Central Line–Associated Bloodstream Infections in Critical Care Patients

National Estimates of Central Line–Associated Bloodstream Infections in Critical Care Patients

Central Venous Catheter Securement: Using the Healthcare and Technology Synergy Model to Take a Closer Look

Surface micropattern reduces colonization and medical device-associated infections

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