New, Male-Specific Microsatellite Markers from the Human Y Chromosome

White, Paul S.; Tatum, Owatha L.; Deaven, Larry L.; Longmire, Jonathan L.

doi:10.1006/geno.1999.5782

Cited by 140 publications

(79 citation statements)

References 11 publications

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“…Two additional markers, DYS388 [29][30] and DYS461 31 were typed separately. The fragments were run on the ABI PRISM 3130xl Genetic Analyzer (Applied Biosystems).…”

Section: Methodsmentioning

confidence: 99%

Distinguishing the co-ancestries of haplogroup G Y-chromosomes in the populations of Europe and the Caucasus

Rootsi

Myres²,

Lin

et al. 2012

Eur J Hum Genet

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Haplogroup G, together with J2 clades, has been associated with the spread of agriculture, especially in the European context. However, interpretations based on simple haplogroup frequency clines do not recognize underlying patterns of genetic diversification. Although progress has been recently made in resolving the haplogroup G phylogeny, a comprehensive survey of the geographic distribution patterns of the significant sub-clades of this haplogroup has not been conducted yet. Here we present the haplogroup frequency distribution and STR variation of 16 informative G sub-clades by evaluating 1472 haplogroup G chromosomes belonging to 98 populations ranging from Europe to Pakistan. Although no basal G-M201* chromosomes were detected in our data set, the homeland of this haplogroup has been estimated to be somewhere nearby eastern Anatolia, Armenia or western Iran, the only areas characterized by the co-presence of deep basal branches as well as the occurrence of high sub-haplogroup diversity. The P303 SNP defines the most frequent and widespread G sub-haplogroup. However, its sub-clades have more localized distribution with the U1-defined branch largely restricted to Near/Middle Eastern and the Caucasus, whereas L497 lineages essentially occur in Europe where they likely originated. In contrast, the only U1 representative in Europe is the G-M527 lineage whose distribution pattern is consistent with regions of Greek colonization. No clinal patterns were detected suggesting that the distributions are rather indicative of isolation by distance and demographic complexities.

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“…Two additional markers, DYS388 [29][30] and DYS461 31 were typed separately. The fragments were run on the ABI PRISM 3130xl Genetic Analyzer (Applied Biosystems).…”

Section: Methodsmentioning

confidence: 99%

Distinguishing the co-ancestries of haplogroup G Y-chromosomes in the populations of Europe and the Caucasus

Rootsi

Myres²,

Lin

et al. 2012

Eur J Hum Genet

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“…Although large numbers of STR loci have been found widely spread all over the genome, only a few Y chromosome specific short tandem repeat polymorphisms have so far been studied. Of these, seven fulfil the criteria for application in forensic and population genetics (Kayser et al 1997 ;de Knijff et al 1997), and 12 other Y specific STRs were recently detected (White et al 1999 ;Ayub et al 2000). In this work we selected four of these new STRs in order to study some of the parameters that are important for their use in population and forensic studies.…”

Section: mentioning

confidence: 99%

Molecular characterisation of four human Y‐specific microsatellites (DYS434, DYS437, DYS438, DYS439) for population and forensic studies

GUSMAO

ALVES

Amorim

2001

Annals of Human Genetics

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In this work we present results on DYS434, DYS437, DYS438 and DYS439 loci studied in three population samples from North Portugal (N : 69), Macao (N : 59) and Mozambique (N : 64). Gene and haplotype diversity values are presented and compared. Gene diversity values ranged from 0.0290 to 0.0620 for DYS434 ; 0.0615 to 0.5959 for DYS437 ; 0.4906 to 0.6424 for DYS438 ; 0.5873 to 0.7038 for DYS439. The highest average gene diversity was found in Macao and the lowest in Mozambique. Haplotype diversity in North Portugal, Macao and Mozambique was calculated to be 0.925, 0.928 and 0.787, respectively.Allele and haplotype frequency distributions for all markers were compared between the three populations. At the haplotype level all the differences between pairs of samples were significant.Sequencing analysis was performed for all alleles found in the four loci. Identical flanking sequences were observed with most of the alleles differing only by the repeat number. However, two variations were found in allele 10 of DYS438 : one in a Macao sample presenting a TTTTA before the last TTTTC repetition and one in a Portuguese sample showing a base substitution (A\C) at position 7 downstream from the tandem repeat. A base substitution (C\T) at position 3 upstream from the repeat motif was also found in allele 14 of DYS437 in a sample from Mozambique.

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“…As more variable Y-STRs are discovered the potential to distinguish paternal lineages increases. Approximately 35 Y-STRs have been described to date [1,[5][6][7][8][9][10][11][12][13][14][15]. In total, these Y-STRs include: four dinucleotide (YCAI, YCAII, YCAII, and DYS288) six trinucleotide (DYF371, DYS388, DYS392, DYS425, DYS426, DYS436), 23 tetranucleotide (DYS19, DYS385, DYS389I, DYS389AB, DYS390, DYS391, DYS393, DYS434, DYS435, DY437, DYS439, DYS441, DYS442, DYS443, DYS444, DYS445, DYS460, DYS461, DYS462, G10123, A10, C4, and H4), and two pentanucleotide repeats (DXYS156Y, and DYS438).…”

Section: Introductionmentioning

confidence: 99%

Forensic value of 14 novel STRs on the human Y chromosome

Redd

Agellon

Kearney

et al. 2002

Forensic Science International

146

106

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We identified and characterized 14 novel short-tandem-repeats (STRs) on the Y chromosome and typed them in two samples, a globally diverse panel of 73 cell lines, and 148 individuals from a European-American population. These Y-STRs include eight tetranucleotide repeats (DYS449, DYS453, DYS454, DYS455, DYS456, DYS458, DYS459, and DYS464), five pentanucleotide repeats (DYS446, DYS447, DYS450, DYS452, and DYS463), and one hexanucleotide repeat (DYS448). Sequence data were obtained to designate a repeat number nomenclature. The gene diversities of an additional 22 Y-STRs, including the most commonly used in forensic databases, were directly compared in the cell line DNAs. Six of the 10 most polymorphic markers include the newly identified Y-STRs. Furthermore, these novel Y-STRs greatly improved the resolution of paternal lineages, above the level obtained with commonly used Y-STRs, in the European-American population. #

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New, Male-Specific Microsatellite Markers from the Human Y Chromosome

Cited by 140 publications

References 11 publications

Distinguishing the co-ancestries of haplogroup G Y-chromosomes in the populations of Europe and the Caucasus

Distinguishing the co-ancestries of haplogroup G Y-chromosomes in the populations of Europe and the Caucasus

Molecular characterisation of four human Y‐specific microsatellites (DYS434, DYS437, DYS438, DYS439) for population and forensic studies

Forensic value of 14 novel STRs on the human Y chromosome

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