“…Taking into account the above-reported existing methodologies and their limitations, as well the recent advances in artificial intelligence (AI), the application of machine-learning algorithms appears to be a promising approach for diagnosis and prediction in several fields, such as ACL injury [ 24 , 25 , 26 , 27 , 28 , 29 , 30 ], and, more generally, in biomedicine approaches [ 31 , 32 , 33 ]. Focusing on ACL, diagnosis and prediction represent two correlated analyses that permit us to solve two different issues.…”