Abstract:Background: Respiratory Syncytial Virus (RSV) is the major cause of severe acute respiratory tract illness in young children worldwide and a main pathogen for the elderly and immune-compromised people. In the absence of vaccines or effective treatments, a better characterization of the pathogenesis of RSV infection is required. To date, the pathophysiology of the disease and its diagnosis has mostly relied on chest X-ray and genome detection in nasopharyngeal swabs. The development of new imaging approaches is… Show more
“…In their brief report, Frétaud et al [ 8 ] combine tissue clearing and 3D deep imaging of the entire mouse lung to visualize Respiratory Syncytial Virus (RSV) infection at a cellular resolution. Deep tissue imaging using light-sheet or 2-photon microscopy allowed them to visualize the distribution of the RSV-infected cells in their tissue environment.…”
“…In their brief report, Frétaud et al [ 8 ] combine tissue clearing and 3D deep imaging of the entire mouse lung to visualize Respiratory Syncytial Virus (RSV) infection at a cellular resolution. Deep tissue imaging using light-sheet or 2-photon microscopy allowed them to visualize the distribution of the RSV-infected cells in their tissue environment.…”
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