New long-acting injectable microspheres prepared by IVL-DrugFluidic™ system: 1-month and 3-month in vivo drug delivery of leuprolide

Application of biodegradable microsphere injections: an anticancer perspective

“…Recently, investigators have reported a new preparation method for leuprolide microspheres based on micro-electromechanical systems and the IVL-DrugFluidic™ microsphere technology of the microfluidic system. 85 PLGA-based 1 month formulation and PLA 3-based formulation prepared based on this technique was compared with commercially available microspheres. The results showed that the microspheres produced by the IVL-DrugFluidic™ system have the advantages of reducing the initial burst release, increasing the level of testosterone inhibition, and stabilizing the concentrations of API in the plasma.…”

Human immunodeficiency virus infection challenges: Current therapeutic limitations and strategies for improved management through long‐acting injectable formulation

“…44 Enhancing the body's tolerance to drugs is one approach to providing long-acting treatments by prolonging their gradual, controlled release while maintaining their active ingredients. 52 Currently, a patient must follow these steps to initiate the regimen: (1) assessing the patient's suitability for treatment, (2) establishing tolerability by initiating therapy with an oral formulation before…”

“…47,57 Through injectable modes of administration, therapeutic drugs can be delivered with controlled release over extended periods, ranging from days to months, utilising LAI formulations. 47,52,58 In addition to reducing the frequency of pills and promoting privacy, long-acting injectables can help overcome further barriers to oral adherence. 59,60 LAI formulations are scientifically engineered to enhance medication pharmacokinetics and therapeutic efficacy while being safer and more efficient.…”

“…Preparing LAI formulations can involve creating microspheres containing small or large molecular therapeutic compounds distributed or dissolved in biodegradable or biocompatible. 52 Among the most popular drug delivery systems are biodegradable polymeric microspheres, which offer advantages such as prolonged drug release, complete in vivo degradation, and high biocompatibility. This can enhance patient compliance and significantly lessen the negative consequences of repeated therapy.…”

“…Patient compliance can be improved to achieve better treatment outcomes 44 . Enhancing the body's tolerance to drugs is one approach to providing long‐acting treatments by prolonging their gradual, controlled release while maintaining their active ingredients 52 . Currently, a patient must follow these steps to initiate the regimen: (1) assessing the patient's suitability for treatment, (2) establishing tolerability by initiating therapy with an oral formulation before transitioning to the injectable formulation (often referred to as a “lead‐in period”), (3) administering a high initial dosage (loading dose), if tolerated, and (4) then continuing with gradually lowering doses every one to 2 months 53 .…”