New Lipo-Phosphoramidates for Gene Delivery

Abstract

International audienceLipo-phosphoramidates constitute an interesting class of synthetic vectors for gene delivery. A structure-activity relationship study points out that the incorporation of the linoleyl polyunsaturated lipid chains produces efficient vectors for gene delivery in the lung. In addition, neutral lipo-phosphoramidates possessing an imidazole motif in the polar head region have been successfully employed in association with a cationic lipophosphoramide to improve in vitro transfection efficiencies. Our recent achievements on this topic are briefly summarized here

Synthetic Nucleic Acid Delivery Systems: Present and Perspectives

“…Moreover, the cytotoxicity against A549, A375, SKMEL28 cell lines followed the same trend, with BSV18 being the least cytotoxic amphiphile. 127,129 In vivo results showed good transfection activity for BSV18-based lipoplexes in a mouse model of lung delivery aimed at cystic fibrosis treatment. 130 Surprisingly, in vivo 60e was significantly more efficient than 60f.…”