New light on exposure to chemicals and cardiovascular diseases

Broberg, Karin

doi:10.1136/heartjnl-2018-314130

Cited by 3 publications

(7 citation statements)

References 4 publications

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“…Chronic diseases have a multifactorial etiology and exposure at work to heavy metals and pesticides appears as an additional factor in this causal model, associated with CVD and subtypes, and it seems that cumulative exposures are more harmful. 14,15,17,18 However, little is known about the effects of chronic low-level exposure to heavy metals or pesticides on the development of CVD. Also, is known less about the development of CVD related to chemical exposure in doses below tolerance limits, however for long periods.…”

Section: Discussionmentioning

confidence: 99%

“…2 In addition to these factors, exposure at work to chemical substances as metals, solvents, and organic pollutants including pesticides, have been associated with hypertension and CVD. [11][12][13][14][15][16] A study involving Latinos in the United States found a high prevalence of coronary heart disease and atrial fibrillation in those exposed to metals and pesticides. 17 A similar relationship was observed in a case-control study in which Chinese workers exposed to metals have had a higher incidence of coronary artery disease.…”

mentioning

confidence: 99%

“…18 Yet, it seems that exposure to a different chemical or biological agent would have a direct or inflammatory effect on the occurrence of CVD. 18,19 Previous studies that investigated the association of exposure to chemical and biological agents at work with the occurrence of CVD were carried out in specific populations, 15,17,19,20 with a nonprobabilistic sample, 14,15,19,20 in middle and high income-countries. 14,17,20 However, no observational representative sample size study was found, specifically in countries in Latin America, such as Brazil, where working conditions are progressively deteriorating with a loss of rights and increasing informal work.…”

mentioning

confidence: 99%

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Exposure to Chemical and Biological Agents at Work and Cardiovascular Disease in Brazil

Carvalho

Tavares

Bastos³

et al. 2021

Journal of Occupational &Amp; Environmental Medicine

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Investigating the relationship between exposure to chemical and biological agents at work and the occurrence of cardiovascular diseases in a Brazilian national health survey. Methods: A cross-sectional study using the database of 36.442 participants from the Brazilian National Health Survey. Logistic Regression analysis was performed for multivariable models. Results: After adjustments for key confounders, we observed that those individuals exposed to chemical agents and biological materials at work had 62% (95% CI: 1.20; 2.20) and 66% (95% CI: 1.03; 2.65), respectively, higher odds of having cardiovascular disease compared to employed individuals who did not report exposure to biological materials/chemical agents at work. Conclusion: This study draws attention to the role of chemical and biological risks in the occurrence of cardiovascular diseases. In this sense, it is necessary developing systematic and intersectoral actions for Workers' Health Surveillance to promote health and prevent chronic non-communicable diseases.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Exposure to Chemical and Biological Agents at Work and Cardiovascular Disease in Brazil

Carvalho

Tavares

Bastos³

et al. 2021

Journal of Occupational &Amp; Environmental Medicine

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“…Despite the understanding of cardiovascular system development from initiation of embryo development progressively to heart development, Cardiovascular Diseases (CVDs) are the paramount reason for mortality almost world-wide [10] . As per the report of the World Health Organization (WHO), CVDs will be the reason for more than 20.0 million deaths of individuals every year, by the 2030 y [11] .…”

Section: Computationalmentioning

confidence: 99%

Scalable Design and Development of Modified Release Hydrochlorothiazide Formulation Employing Quality by Design Approach

Singhai¹,

Sharma²,

Paliwal³

et al. 2022

IJPS

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Singhai et al.: Quality by Design based Scalable Formulation Development of HydrochlorothiazideMyocardial infarction, generally known as 'heart attack' occurs predominantly during the early morning hours and a cause of millions of death worldwide. Hydrochlorothiazide is the recommended drug for the prevention of heart disease, but the commercial market lacks its long action (>4 h) formulation. The endeavor of the present research was to develop a quality product profile of hydrochlorothiazide modified release tablets (~14 h release) by applying computational quality by design approach. Three independent factors were identified by qualitative and quantitative risk assessment. Selected dependent variables were cumulative percent of dissolved hydrochlorothiazide in 2, 5, 8 and 12 h. Graphical tools like half normal, normal and Pareto charts were used to manage model selection. The graphical relationship among the critical, independent variables was represented using contour plot and three-dimensional surface plot. Design space was identified by plotting overlay plot using three factors, two-level full factorial design. Outstanding correlation was observed between predicted and actual values. Similarity factor (F2) of reproducible trials was 78 and 79, and content uniformity was 100.9 % and 100.4 %. Average weight, hardness, thickness, diameter and friability were within acceptable limits. Quality by design approach, along with quality risk management tool furnished an efficient and effective paradigm to structure quality modified release tablets of hydrochlorothiazide.

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“…In an editorial, Broberg4 discuss the possible mechanisms of occupational exposure to chemicals and CVD risk. “Many metals are strong inducers of oxidative stress which may result in CVD either directly or via increased inflammation.…”

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confidence: 99%