New lectins from Codium isthmocladum Vickers show unique amino acid sequence and antibiofilm effect on pathogenic bacteria

Carneiro, Rômulo Farias; Duarte, Philippe Lima; Chaves, Renata Pinheiro; Silva, Suzete Roberta da; Feitosa, Ramon Rodrigues; Sousa, Bruno; Alves, Antônio Willame da Silva; Vasconcelos, Mayron Alves de; Rocha, B.A.M.; Teixeira, Edson Holanda; Sampaio, Alexandre Holanda; Nagano, Celso Shiniti

doi:10.1007/s10811-020-02198-x

Cited by 7 publications

(3 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, two recently isolated lectins from the green alga C. isthmocladum with galactose-binding activity were found to inhibit biofilm formation of Staphylococcus aureus and S. epidermidis up to 60%, compared to the control samples ( Table 2 ). However, they did not display any significant antibacterial or antibiofilm activity against Escherichia coli [ 71 ]. The mannose-binding lectin griffithsin, derived from the red macroalga genus Griffithsia sp., has become a main focus of research since it was isolated in 2004 [ 72 ].…”

Section: Bioactive Properties and Mechanisms Of Actionmentioning

confidence: 99%

“…Reduced wound size and faster closure in treated mice [ 93 ] Phaeophyceae Sargassum fusiforme Lectin In vitro, antioxidant Dosage of 1.6 mg/mL inhibited 77.23% DPPH; 4 mg/mL inhibited 68.97% ABTS [ 40 ] Saccharina japonica GP In vitro, antioxidant DPPH (IC 50 = 0.12 mg/mL), ABTS (IC 50 = 0.05 mg/mL), FRAP (IC 50 = 0.3 mg/mL) and xanthine oxidase (70%, 0.2 mg/mL) inhibition [ 94 ] Undaria pinnatifida GP In vitro, antidiabetic Rat intestinal (IC 50 = 0.29 mg/mL) and yeast (IC 50 = 0.11 mg/mL) α-glucosidase inhibition. Retained >60% of inhibitory activity after thermal treatments [ 95 ] Chlorophyceae Codium isthmocladum 2 lectins In vitro, antibiofilm Binding to monosaccharide residues of the biofilms with preference to α-linkages [ 71 ] Halimeda renschii Lectin In vitro, antiviral High mannose-binding lectin, bonded with Influenza H3N2 viral envelope hemagglutinin, preventing infection [ 96 ] Boodlea coacta Lectin In vitro, antiviral High mannose-binding lec...…”

Section: Bioactive Properties and Mechanisms Of Actionmentioning

confidence: 99%

See 1 more Smart Citation

Seaweed-Derived Proteins and Peptides: Promising Marine Bioactives

et al. 2022

View full text Add to dashboard Cite

Seaweeds are a typical food of East-Asian cuisine, to which are alleged several beneficial health effects have been attributed. Their availability and their nutritional and chemical composition have favored the increase in its consumption worldwide, as well as a focus of research due to their bioactive properties. In this regard, seaweed proteins are nutritionally valuable and comprise several specific enzymes, glycoproteins, cell wall-attached proteins, red algae phycobiliproteins, lectins, peptides, or mycosporine-like amino acids. This great extent of molecules has been reported to exert significant antioxidant, antimicrobial, anti-inflammatory, antihypertensive, antidiabetic, or antitumoral properties. Hence, knowledge on algae proteins and derived compounds have gained special interest for the potential nutraceutical, cosmetic or pharmaceutical industries based on these bioactivities. Although several molecular mechanisms of action on how these proteins and peptides exert biological activities have been described, many gaps in knowledge still need to be filled. Updating the current knowledge related to seaweed proteins and peptides is of interest to further asses their potential health benefits. This review addresses the characteristics of seaweed protein and protein-derived molecules, their natural occurrence, their studied bioactive properties, and their described potential mechanisms of action.

show abstract

Section: Bioactive Properties and Mechanisms Of Actionmentioning

confidence: 99%

Section: Bioactive Properties and Mechanisms Of Actionmentioning

confidence: 99%

Seaweed-Derived Proteins and Peptides: Promising Marine Bioactives

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Bioactive compounds derived from proteins such as lectins can be obtained from Codium species. Carneiro et al (2020) isolated lectins from C. isthmocladum and found two novel lectins, CiL-1 and CiL-2, with unique sequences not found in other lectins.…”

Section: Proteinsmentioning

confidence: 99%

A concise review of the bioactivity and pharmacological properties of the genus Codium (Bryopsidales, Chlorophyta)

2022

View full text Add to dashboard Cite

The genus Codium is one of the most important genera of marine green macroalgae. Its distribution is widespread worldwide and it has a high degree of diversity in species and characteristics. This genus plays an important ecological role in marine ecosystems as it is a primary producer. However, some species in the genus Codium are invasive species and may disturb the functioning of the ecosystem. Economically, Codium has promising potential as a source of diverse nutritional and pharmacological compounds. Codium is edible, has a high nutrient value, and is rich in bioactive compounds. Hence, some species of Codium have been consumed as food and used as herbal medicines in some Asian countries. In recent decades, studies of the bioactivity and pharmacological properties of the genus Codium have attracted the attention of scientists. This review aims to identify gaps in studies analyzing Codium that have been conducted in the past three decades by assessing published research articles on its bioactivity and pharmacological properties. Compounds obtained from Codium have demonstrated significant biological activities, such as immunostimulatory, anticoagulant, anticancer, anti-inflammatory, antioxidant, antiviral, antibacterial, antifungal, antitumor, anti-angiogenic, osteoprotective, and anti-obesity activities. This review provides information that can be used as a future guideline for sustainably utilizing the genus Codium.

show abstract

The Seaweed a Gold Mine for Drugs

Kumar

Arunkumar

2023

Sustainable Development and Biodiversity

View full text Add to dashboard Cite

New lectins from Codium isthmocladum Vickers show unique amino acid sequence and antibiofilm effect on pathogenic bacteria

Cited by 7 publications

References 46 publications

Seaweed-Derived Proteins and Peptides: Promising Marine Bioactives

Seaweed-Derived Proteins and Peptides: Promising Marine Bioactives

A concise review of the bioactivity and pharmacological properties of the genus Codium (Bryopsidales, Chlorophyta)

The Seaweed a Gold Mine for Drugs

Contact Info

Product

Resources

About