New lead (II) selective membrane potentiometric sensors based on chiral 2,6-bis-pyridinecarboximide derivatives

Hassan, Saad S. M.; Ghalia, M.H Abou; Amr, Abd El‐Galil E.; Mohamed, Ayman H. K.

doi:10.1016/s0039-9140(03)00038-9

Cited by 68 publications

(31 citation statements)

References 27 publications

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“…Although both electrodes presented worse detection limits when studies were made at pH 6.0, these values are similar, or better, than the detection limits for some reported lead(II) potentiometric sensors. 3,5,[9][10][11][12][13][14]16,18,19,29 The DTB and MB electrodes present similar detection limits at pH 4.2, which are minor compared to that obtained when the pH value is 6.0. According to our knowledge, there are no other papers with better detection limits for lead(II) ions than those presented here at pH 4.2.…”

Section: Cmcpes Characterizationmentioning

confidence: 73%

“…Besides mercury(II), copper(II), cadmium(II) and iron(III) ions must not to be present in the sample due to the high interference that they produce in the electrode potentiometric response. Therefore, in the last few years, to improve lead determinations, several potentiometric sensors with liquid membrane based on calixarene, [3][4][5][6] crown ethers, [7][8][9][10][11] benzyl disulfide, 12 capric acid, 13 piroxicam, 14 anthraquinone derivative, 15 Schiff base, 16 and other ionophores [17][18][19] have been reported.…”

Section: Introductionmentioning

confidence: 99%

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Potentiometrie Carbon Paste Sensors for Lead(II) Based on Dithiodibenzoic and Mercaptobenzoic Aeids

2006

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Experimental ReagentsAll reagents used were of analytical reagent grade. Dithiodibenzoic (DTB) acid and mercaptobenzoic (MB) acid were studied to characterize their abilities as modifier agents for lead(II) sensors. For both sensors, the best results were obtained with modified carbon paste electrodes with 24.1% of ligand. The pH influence on the potentiometric response was studied. The selectivity coefficients for both modified electrodes were tabulated. A potentiometric sensor based on DTB acid exhibited a more sensitive and selective response to lead ions than an MB electrode. The limits of detection for the DTB and MB electrodes were very similar, 5.01 × 10 -8 M and 3.98 × 10 -8 M, respectively, for lead(II) activity. The DTB sensor was applied to lead(II) ion determination in real samples and as an indicator electrode in potentiometric titrations. Natural and commercial humic acids were titrated using the DTB electrode to estimate the stability constant between these organic compounds and the lead(II) ions with successful results.

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Section: Cmcpes Characterizationmentioning

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Potentiometrie Carbon Paste Sensors for Lead(II) Based on Dithiodibenzoic and Mercaptobenzoic Aeids

2006

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“…Table 3 lists the linear range, detection limit, lifetime and slope of some of the lead-selective electrodes against the proposed lead-selective electrode for comparative purposes. [5][6][7][9][10][11] As can be seen from Table 3, many of the reported lead-selective electrodes respond to lead with a less than linear range, worse selectivity and also near Nernstian slope with respect to proposed lead-selective electrodes.…”

Section: Response Characteristics Of the Electrodesmentioning

confidence: 96%

“…1 During the past two decades, an extensive effort has been focused on the synthesis and characterization of various carriers with high selectivity for lead ion to develop new potentiometric sensors for the determination of Pb 2+ ions in different real samples. [2][3][4][5][6][7][8][9][10][11][12][13] However, these efforts on lead ion electrodes have not been very fruitful because the reported electrodes have either one, two or, in some cases, the entire figures of merits, which are no adequate (such as: near Nernstian slope, narrow linear range, high detection limit and interferences from various ions).…”

Section: Introductionmentioning

confidence: 99%

Bis(2-hydroxyacetophenone)ethylenediimine as a Neutral Carrier in a Coated-Wire Membrane Electrode for Lead(II)

2006

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A coated-wire ion-selective electrode (CWISE), based on a Schiff base as a neutral carrier, was successfully developed for the detection of Pb(II) in aqueous solution. CWISE exhibited a linear response with a Nernstian slope of 29.4 ± 0.5 mV/decade within the concentration range of 1.0 × 10 -5 -1.0 × 10 -1 M lead ion. CWISE has shown detection limits of 5.0 × 10 -6 M. The electrode exhibited good selectivity over a number of alkali, alkaline earth, transition and heavy metal ions. This sensor yielded a steady potential within 10 to 20 s at a linear dynamic range. The electrode was suitable for use in aqueous solutions in a pH range of 2.0 to 5.0. Applications of this electrode for the determination of lead in real samples and as indicator electrode for potentiometric titration of Pb 2+ ion using K2CrO4 are reported.

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“…In addition, the pharmacological and antitumor activities of many heterocyclic compounds have been reviewed (17)(18)(19). Recently, nitrogenous derivatives exhibited a general ionophoric potency for divalent cations (20) and are used as novel thiocyanate-selective membrane sensors (21). In view of these reports and in continuation of our previous work in heterocyclic chemistry, we have herein synthesized some new compounds containing steroidal structure for the evaluation of androgenic-anabolic activity as compared to testosterone as standard drug (Fig.…”

mentioning

confidence: 99%

New steroidal derivatives synthesized using 3β-hydroxyandrosten-17-one as starting material

El-Latif¹,

Abdulla²,

Amr³

2008

Acta Pharmaceutica

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Natural steroids and their synthetic congeners were extensively studied during the last decade (1, 2). In a previous work, some new heterocyclic compounds showing antiparkinsonian (3), antitumor (4-6), antimicrobial (7-10) and anti-inflammatory (11) activity were synthesized. We found that certain substituted steroidal derivatives showed androgenic, anabolic and anti-inflammatory activities (12). Steroidal pyrazolines are an interesting group of compounds, many of which possess wide spread pharmacological properties such as analgesic, antipyretic and antiandrogenic activities (13,14). These derivatives are also well known for their pronounced anti-inflammatory (15) activity and are used as potent antidiabetic agents (16). In addition, the pharmacological and antitumor activities of many heterocyclic compounds have been reviewed (17)(18)(19). Recently, nitrogenous derivatives exhibited a general ionophoric potency for divalent cations (20) and are used as novel thiocyanate-selective membrane sensors (21). In view of these reports and in continuation of our previous work in heterocyclic chemistry, we have herein synthesized some new compounds containing steroidal structure for the evaluation of androgenic-anabolic activity as compared to testosterone as standard drug (Fig. 1). Accepted February 5, 2008 In this study, we synthesized some new substituted steroidal derivatives using 3b-hydroxyandrosten-17-one (dehydroepiandrosterone) as starting material. The synthesized steroidal derivatives 1-11 were evaluated for their androgenic-anabolic activities compared to testosterone as positive control. Details of the synthesis, spectroscopic data and toxicity (LD 50 ) of synthesized compounds are reported.

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New lead (II) selective membrane potentiometric sensors based on chiral 2,6-bis-pyridinecarboximide derivatives

Cited by 68 publications

References 27 publications

Potentiometrie Carbon Paste Sensors for Lead(II) Based on Dithiodibenzoic and Mercaptobenzoic Aeids

Potentiometrie Carbon Paste Sensors for Lead(II) Based on Dithiodibenzoic and Mercaptobenzoic Aeids

Bis(2-hydroxyacetophenone)ethylenediimine as a Neutral Carrier in a Coated-Wire Membrane Electrode for Lead(II)

New steroidal derivatives synthesized using 3β-hydroxyandrosten-17-one as starting material

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