New lanostane-type triterpenoids, inonotsutriols D, and E, from Inonotus obliquus

Cytotoxic Evaluation of Compounds Isolated from the Aerial Parts of Hedyotis pilulifera and Methanol Extract of Inonotus obliquus

“…Generally, the long experience of ethnomedicine should not be underestimated and our previous results [6,[15][16][17][18] demonstrated that some popular plants of Estonian and Asian folk medicine showed cytotoxic effect. Anticancer activity of chaga extracts in vitro on HL-60 and HepG2 cells has also been shown by other authors [19][20]. In this study the anticancer action of extracts prepared from chaga sclerotium on human lung carcinoma (LU-1), colon adenocarcinoma (SW480), and oral epidermoid carcinoma (KB) is described for the first time.…”

Stimulated production of steroids in Inonotus obliquus by host factors from birch

“…Thus, polyphenols, triterpenoids, and polysaccharides in the birch were considered as simulators for the steroid biosynthesis of I. obliquus. Fungi digest food outside their bodies by releasing enzymes into the surrounding environment, breaking down organic matter into a form the fungus can then absorb (17,20,24,25). These compounds such as saccharides, terpenoids, and phenols not only involved in sterol biosynthesis directly, but also glucose derived from polysaccharides metabolism was beneficial for sterol biosynthesis.…”

Triterpenoids

“…39 Inonotsutriols D 37 and E 38 have been reported from the white rot fungus Inonotus obliquus. 40 glycosides with known genins, liouvillosides A 4 and A 5 , have been isolated from the sea cucumber Staurocucumis liouvillei. 46 Interesting new compounds from Schisandra species include henrischinins A-C 44-46 from Schisandra henryi with an oxabicyclo [3.2.1]octane moiety in the side chain, 47 the bisnorderivative schinarisanlactone A 47 from Schisandra arisanensis 48 and the tricyclic derivative schiglautone A 48 from the stems of Schisandra glaucescens.…”