New laboratory perspectives for evaluation of vivax malaria infected patients: a useful tool for infection monitoring

Alves-Junior, Eduardo Rodrigues; Gomes, Luciano Teixeira; Dombroski, Thaís Caroline Dallabona; Nery, Andréia Ferreira; Vandresen-Filho, Samuel; Nakazato, Luciano; Fontes, Cor Jésus Fernandes; Rios-Santos, Fabrício

doi:10.1016/j.bjid.2020.04.001

Cited by 7 publications

(9 citation statements)

References 42 publications

(42 reference statements)

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“…The ESR of infected subjects was significantly higher than those of the controls. The result obtained in this study is in line with previous reports [14,15] of Brewerton and James [14].…”

Section: Discussionsupporting

confidence: 93%

Haematological Derrangement Due to <i>P. falciparum</i> Infection in Patients of Selected Health Centres in Ardo-Kola Local Government Area, Taraba State

Sambo¹,

Chibuzor²,

Chinwe³

et al. 2020

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“…The ESR of infected subjects was significantly higher than those of the controls. The result obtained in this study is in line with previous reports [14,15] of Brewerton and James [14].…”

Section: Discussionsupporting

confidence: 93%

Haematological Derrangement Due to <i>P. falciparum</i> Infection in Patients of Selected Health Centres in Ardo-Kola Local Government Area, Taraba State

Sambo¹,

Chibuzor²,

Chinwe³

et al. 2020

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“…Elevations in γGT and ALP have also been reported in relation to liver injury in uncomplicated malaria ( Reuling et al., 2018 ). Moreover, bilirubinemia has been suggested as a common marker of Pv acute infection and as a predictor of infection severity ( Alves-Junior et al., 2020 ; Odedra et al., 2020 ; Almeida et al., 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Epidemiological characteristics of P. vivax asymptomatic infections in the Peruvian Amazon

Villasis

Castillo

Guzmán

et al. 2022

Front. Cell. Infect. Microbiol.

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IntroductionHerein, we tested the hypothesis that Asymptomatic P. vivax (Pv) infected individuals (Asym) feature different epidemiological, clinical and biochemical characteristics, as well as hematological parameters, potentially predictive of clinical immunity in comparison to symptomatic Pv infected individuals (Sym).MethodologyBetween 2018 - 2021, we conducted 11 population screenings (PS, Day 0 (D0)) in 13 different riverine communities around Iquitos city, in the Peruvian Amazon, to identify Pv Sym and Asym individuals. A group of these individuals agreed to participate in a nested case - control study to evaluate biochemical and hematological parameters. Pv Asym individuals did not present common malaria symptoms (fever, headache, and chills), had a positive/negative microscopy result, a positive qPCR result, reported no history of antimalarial treatment during the last month, and were followed-up weekly until Day 21 (D21). Control individuals, had a negative malaria microscopy and qPCR result, no history of antimalarial treatment or malaria infections during the last three years, and no history of comorbidities or chronic infections.ResultsFrom the 2159 individuals screened during PS, data revealed a low but heterogeneous Pv prevalence across the communities (11.4%), where most infections were Asym (66.7%) and submicroscopic (82.9%). A total of 29 Asym, 49 Sym, and 30 control individuals participated in the nested case - control study (n=78). Ten of the individuals that were initially Asym at D0, experienced malaria symptoms during follow up and therefore, were included in the Sym group. 29 individuals remained Asym throughout all follow-ups. High levels of eosinophils were found in Asym individuals in comparison to Sym and controls.ConclusionFor the first-time, key epidemiological, hematological, and biochemical features are reported from Pv Asym infections from the Peruvian Amazon. These results should be considered for the design and reshaping of malaria control measures as the country moves toward malaria elimination.

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“…These findings further promote the potential roles of the fibrinolytic markers in the diagnosis of PJI. Despite the fibrinolytic markers, several plateletrelated markers, such as platelet count (PLT), mean platelet volume (MPV) and plateletcrit (PCT), have also been found to fluctuate during inflammatory and infection [12,13]. Recent research has reported that the migrating platelets collect and bundle the microbial invaders, boost the activity of phagocytes and activate innate immune responses during infection [14].…”

Section: Introductionmentioning

confidence: 99%

Globulin and albumin to globulin ratio precisely diagnose periprosthetic joint infection and determine the timing of second-stage reimplantation

Shang

Fei

et al. 2022

J Orthop Surg Res

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Background Periprosthetic joint infection (PJI) is one of the most challenging complications of total joint arthroplasty (TJI). An early and accurate diagnosis of PJI is associated with better treatment outcomes. However, whether the platelet-related markers and globulin-related markers can be used to assist the diagnosis of PJI remains elusive. Methods A total of 206 patients who underwent revision hip or knee arthroplasty in our institution were divided into two groups: 79 patients in PJI group and 127 patients in aseptic failure group. The levels of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), platelet-related markers including platelet count (PLT), mean platelet volume (MPV), plateletcrit (PCT) and PLT to MPV ratio (PMR) and globulin-related markers such as globulin (GLB), albumin to globulin ratio (AGR) and PLT to AGR ratio were compared. The diagnostic value was measured using area under the curve (AUC) after constructing receiver operating characteristic (ROC) curves. The potential of each marker for determining the timing of second-staged reimplantation was also evaluated. Results Significantly increased levels of ESR, CRP, PLT, PCT, PMR, GLB and PLT to AGR ratio were identified in PJI group, while decreased levels of MPV and AGR were also found. The diagnostic values of all platelet-related markers and GLB were considered as fair, and good diagnostic values of AGR and PLT to AGR ratio were found, which were comparable to those of ESR and CRP. The levels of GLB and AGR can also be used to predict negative culture result and the timing of second-stage reimplantation. Conclusions Globulin and albumin to globulin ratio were found to have good diagnostic values for PJI, and they can precisely predict the culture results and persistent infection.

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New laboratory perspectives for evaluation of vivax malaria infected patients: a useful tool for infection monitoring

Cited by 7 publications

References 42 publications

Haematological Derrangement Due to <i>P. falciparum</i> Infection in Patients of Selected Health Centres in Ardo-Kola Local Government Area, Taraba State

Haematological Derrangement Due to <i>P. falciparum</i> Infection in Patients of Selected Health Centres in Ardo-Kola Local Government Area, Taraba State

Epidemiological characteristics of P. vivax asymptomatic infections in the Peruvian Amazon

Globulin and albumin to globulin ratio precisely diagnose periprosthetic joint infection and determine the timing of second-stage reimplantation

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New laboratory perspectives for evaluation of vivax malaria infected patients: a useful tool for infection monitoring

Cited by 7 publications

References 42 publications

Haematological Derrangement Due to &lt;i&gt;P. falciparum&lt;/i&gt; Infection in Patients of Selected Health Centres in Ardo-Kola Local Government Area, Taraba State

Haematological Derrangement Due to &lt;i&gt;P. falciparum&lt;/i&gt; Infection in Patients of Selected Health Centres in Ardo-Kola Local Government Area, Taraba State

Epidemiological characteristics of P. vivax asymptomatic infections in the Peruvian Amazon

Globulin and albumin to globulin ratio precisely diagnose periprosthetic joint infection and determine the timing of second-stage reimplantation

Contact Info

Product

Resources

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Haematological Derrangement Due to <i>P. falciparum</i> Infection in Patients of Selected Health Centres in Ardo-Kola Local Government Area, Taraba State

Haematological Derrangement Due to <i>P. falciparum</i> Infection in Patients of Selected Health Centres in Ardo-Kola Local Government Area, Taraba State