New Labdane-Type Diterpenoid and Cytotoxic Constituents of Hedychium coronarium

Cytotoxic Labdane Diterpenes, Norlabdane Diterpenes and Bis-Labdanic Diterpenes from the Zingiberaceae: A Systematic Review

“…Among the forty-four cytotoxic labdane-type diterpenes identified through this search, forty are characterized as labdane diterpenes (3-27, 29-37, 39-44), two as norlabdane diterpenes (28,38) and two as bis-labdanic diterpenes (1, 2) (Table 3 and Figure S1). The following sections will discuss the structural similarities and differences within each group of the labdane-type diterpenes and between the different groups of the labdane-type diterpenes.…”

“…In general, the basic framework and the relative stereochemistry for these compounds are similar to those of the labdane diterpenes, with the only difference being in the nature of the side chain at position C-9 of the decalin moiety. For compounds 28 and 38, instead of having a branched, six-membered carbon side chain, these compounds have either a three-membered (38) or a four-membered (28) aliphatic chain, in turn resulting in these compounds having fewer than 20 carbon atoms in their respective structures (Figure S1).…”

“…Weak MTT [38] HCT-116 Cell Line There were only two recent studies which evaluated the cytotoxicity of the labdanetype diterpenes from the Zingiberaceae against this cell line.…”

Anti-Inflammatory Terpenoids from the Rhizomes of Shell Ginger

“…It was a rare meroterpenoid resulting from the Diels−Alder cycloaddition between phenylpropanoic acid and monoterpene as a diene. Twenty-three known terpenoids were confirmed via comparison of their NMR data with the published data as pahangensin B (1), 37 coronarin D ethyl ether (6), 38 (12E)labda-8(17),12,14-trien-16,15-olide (7), 39 villosin (8), 40 labda-8 (17),13( 14)-dien-15,16-olide (10), 29 (12E)-labda-8(17),12-(13)-dien-16,15-olide (11), 38 (12S)-15,16-epoxy-12-hydroxylabda-8(17),13( 16),14-triene (13), 26 (12R)-15,16-epoxy-12hydroxy-labda-8(17),13( 16),14-triene ( 14), 26 12,15-epoxylabda-8(17),12,14-trien-16-al ( 16), 41 zerumin (17), 42 obtunone (18), 43 podocarpa-8,11,13-trien-12-ol (19), 44 podocarpa-8,11,13-trien-13-ol (21), 44 hedychiumin (22), 45 (11E)-14,15,16-trinorlabda-8(17),11-dien-13-al (23), 46 (11E)-14,15,16-trinorlabda-8(17),11-dien-13-oic acid (25), 39 13,14,15,16-tetranorlabda-8(l7)-en-12-oic acid (26), 26 isodrimenin ( 27), 47 α-cadinol (31), 48 α-eudesmol (32), 49 βeudesmol (33), 50 γ-eudesmol (34), 51 and caryophyllenol-I (35). 52 Anti-Inflammatory Activities.…”

High-Performance Thin Layer Chromatography Method Development to Estimate Phytoconstituents in Hedychium species

“…Numerous chemotypic forms of essential Oils have been recorded in literature are as follows: α-pinene, β-pinene,1,8-cineole, β-caryophyllene, γ-elemene, β-trans ocimenone, linalool, caryophyllene oxide, β-caryophyllene, caryophylladienol I. [3][4][5][6][7][8][9][10][11] The H. coronarium has a variety of pharmacological properties, such as anti-bacterial, antiangiogenic, anti-microbial, anti-oxidant, anti-inflammatory, anti-fungal, anti-urolithiasis, mosquito larvicidal, analgesic, cancer-chemopreventive, diuretic, anti-hypertensive, hypoglycemic and CNS depressive effects. Hence, the present study was planned to study the plant's pharmacognostic characteristics, such as its morphology and phytochemical screening of plant H. coronarium in different solvents like ethanol, chloroform, and water.…”