New Labdane diterpenes as intestinal α-glucosidase inhibitor from antihyperglycemic extract of Hedychium spicatum (Ham. Ex Smith) rhizomes

Reddy, P. Prabhakar; Tiwari, Ashok Kumar; Rao, R. Ranga; Madhusudhana, K.; Rao, V. Rama Subba; Ali, Amtul Z.; Babu, K. Suresh; Rao, J. Madhusudana

doi:10.1016/j.bmcl.2009.03.045

Cited by 63 publications

(12 citation statements)

References 13 publications

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“…Morus alba is another plant species for which AG inhibitory activity has been well-studied [44], and its leaf extracts exhibited AG inhibition activity with an IC50 value of 91.63 µg/mL compared to that of acarbose (IC50: 402.33 µg/mL) [45]. A range of bioactive compounds isolated from the leaves of Mango (Mangifera indica L.) were screened for their inhibitory effect against AG and among them arjunolic acid and actinidic acid exhibited inhibitory activity with IC50 values of 239.60 ± 25.00 and 297.37 ± 8.12 7.08 µg/mL (9.68 µg/mL) [34] Iminosugars N-(9 -methoxynonyl)-1-deoxynojirimycin…”

Section: Plants With Ag Inhibitory Activitymentioning

confidence: 99%

Alpha Glucosidase Inhibitory Activities of Plants with Focus on Common Vegetables

Assefa

Yang

Chae

et al. 2019

Plants

112

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Type-2 diabetes mellitus is one of the most prevalent metabolic diseases in the world, and is characterized by hyperglycemia (i.e., high levels of glucose in the blood). Alpha-glucosidases are enzymes in the digestive tract that hydrolyze carbohydrates into glucose. One strategy that has been developed to treat type-2 diabetes is inhibition of the activity of alpha-glucosidases using synthetic drugs. However, these inhibitors are usually associated with gastrointestinal side effects. Therefore, the development of inhibitors from natural products offers an alternative option for the control of hyperglycemia. In recent years, various studies have been conducted to identify alpha-glucosidases inhibitors from natural sources such as plants, and many candidates have transpired to be secondary metabolites including alkaloids, flavonoids, phenols, and terpenoids. In this review, we focus on the alpha-glucosidases inhibitors found in common vegetable crops and the major classes of phytochemicals responsible for the inhibitory activity, and also as potential/natural drug candidates for the treatment of type-2 diabetes mellitus. In addition, possible breeding strategies for production of improved vegetable crops with higher content of the inhibitors are also described.Plants 2020, 9, 2 2 of 17 potential α-glucosidase inhibitors (AGIs) have been extensively screened or studied and acarbose, miglitol, voglibose, and 1-deoxynojirimycin (DNJ) are currently commercialized anti-glucosidase drugs (Figure 1; [7]) against type-2 diabetes, a chronic condition in which the body becomes resistant to the normal effects of insulin, resulting in ineffectiveness at managing the blood glucose levels.

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Section: Plants With Ag Inhibitory Activitymentioning

confidence: 99%

Alpha Glucosidase Inhibitory Activities of Plants with Focus on Common Vegetables

Assefa

Yang

Chae

et al. 2019

Plants

112

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“…Among these, eremanthin exhibited hypoglycemic and hypolipidemic activities [23], while andrographolide was potent for diabetic control [24,25,26,27]. There were several other reports on antidiabetic activity of diterpenes and their synthetic derivatives [28,29,30,31,32].…”

Section: Introductionmentioning

confidence: 99%

Momilactones A and B Are α-Amylase and α-Glucosidase Inhibitors

et al. 2019

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Momilactones A (MA) and B (MB) are the active phytoalexins and allelochemicals in rice. In this study, MA and MB were purified from rice husk of Oryza sativa cv. Koshihikari by column chromatography, and purification was confirmed by high-performance liquid chromatography, thin-layer chromatography, gas chromatography-mass spectrometry, liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS), and 1H and 13C nuclear magnetic resonance analyses. By in vitro assays, both MA and MB exerted potent inhibition on α-amylase and α-glucosidase activities. The inhibitory effect of MB on these two key enzymes was greater than that of MA. Both MA and MB exerted greater α-glucosidase suppression as compared to that of the commercial diabetic inhibitor acarbose. Quantities of MA and MB in rice grain were 2.07 ± 0.01 and 1.06 ± 0.01 µg/dry weight (DW), respectively. This study was the first to confirm the presence of MA and MB in refined rice grain and reported the α-amylase and α-glucosidase inhibitory activity of the two compounds. The improved protocol of LC-ESI-MS in this research was simple and effective to detect and isolate MA and MB in rice organs.

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“…Accordingly, recent research seems to have granted special interest for the search of effective natural α-amylase and ACE inhibitors. In the same vein, essential oil isolated from plant sources, have attracted a great deal of attention in the biomedical arena particularly for their broad spectrum of therapeutic properties and relatively low toxicity [7,8]. Numerous studies have confirmed that consumption of omega-3 reduces the risk of developing chronic diseases such as diabetes and heart disease [9-11].…”

Section: Introductionmentioning

confidence: 99%

Inhibitory potential of omega-3 fatty and fenugreek essential oil on key enzymes of carbohydrate-digestion and hypertension in diabetes rats

et al. 2011

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Backgrounddiabetes is a serious health problem and a source of risk for numerous severe complications such as obesity and hypertension. Treatment of diabetes and its related diseases can be achieved by inhibiting key digestives enzymes-related to starch digestion secreted by pancreas.MethodsThe formulation omega-3 with fenugreek terpenenes was administrated to surviving diabetic rats. The inhibitory effects of this oil on rat pancreas α-amylase and maltase and plasma angiotensin-converting enzyme (ACE) were determined.Resultsthe findings revealed that administration of formulation omega-3 with fenugreek terpenenes (Om3/terp) considerably inhibited key enzymes-related to diabetes such as α-amylase activity by 46 and 52% and maltase activity by 37 and 35% respectively in pancreas and plasma. Moreover, the findings revealed that this supplement helped protect the β-Cells of the rats from death and damage. Interestingly, the formulation Om3/terp modulated key enzyme related to hypertension such as ACE by 37% in plasma and kidney. Moreover administration of fenugreek essential oil to surviving diabetic rats improved starch and glucose oral tolerance additively. Furthermore, the Om3/terp also decreased significantly the glucose, triglyceride (TG) and total-cholesterol (TC) and LDL-cholesterol (LDL-C) rates in the plasma and liver of diabetic rats and increased the HDL-Cholesterol (HDL-Ch) level, which helped maintain the homeostasis of blood lipid.Conclusionoverall, the findings of the current study indicate that this formulation Om3/terp exhibit attractive properties and can, therefore, be considered for future application in the development of anti-diabetic, anti-hypertensive and hypolipidemic foods.

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New Labdane diterpenes as intestinal α-glucosidase inhibitor from antihyperglycemic extract of Hedychium spicatum (Ham. Ex Smith) rhizomes

Cited by 63 publications

References 13 publications

Alpha Glucosidase Inhibitory Activities of Plants with Focus on Common Vegetables

Alpha Glucosidase Inhibitory Activities of Plants with Focus on Common Vegetables

Momilactones A and B Are α-Amylase and α-Glucosidase Inhibitors

Inhibitory potential of omega-3 fatty and fenugreek essential oil on key enzymes of carbohydrate-digestion and hypertension in diabetes rats

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