New Isoflavanes from Spatholobus suberectus and Their Cytotoxicity against Human Breast Cancer Cell Lines

Abstract

The rattans of Spatholobus suberectus Dunn are a traditional Chinese medicine activating blood circulation and removing stasis. They have often been used for the traditional Chinese medicinal treatment of breast cancer in modern China. In this study, four novel isoflavanes (1–3 and 5) and four known analogues (4 and 6–8) were isolated from an ethanolic extract of the rattans of S. suberectus. Their structures were elucidated by extensive spectroscopic analyses and electronic circular dichroism studies. MCF-7 and MDA-MB-231 human breast cancer cell lines were used to evaluate the cytotoxic effects of the isolates. Interestingly, compounds 1 and 2 only inhibited the proliferation of MCF-7 cells, while compound 6 showed a selective cytotoxicity against MDA-MB-231 cells. However, compound 4 had significant cytotoxicity against both MCF-7 and MDA-MB-231 cell lines.

The Antitriple Negative Breast cancer Efficacy of Spatholobus suberectus Dunn on ROS‐Induced Noncanonical Inflammasome Pyroptotic Pathway

“…Earlier, several studies were reported that SSD comprised of various bioactive compounds, viz., (-)-sativan, formononetin, isoliquiritigenin, genistein, naringenin, medicarpin, prestegane, naringenin, blumenol A, protocatechuic acid, liquiritigenin, 7,4′-dihydroxy-8-methoxy-isoflavone, protocatechuic acid, glycyroside, and dulcisflavan that possesses cytotoxicity, anticancer, and antimutagenic properties [ 7 , 8 , 13 , 14 , 19 ]. The present study is also exhibited five distinguished bioactive compounds, viz., catechin, procyanidin B2, epicatechin, genistein, and formononetin, and all of them have greater antitumor, antimutagenic, and potential genotoxic effects [ 31 , 32 , 54 – 59 ].…”

“…SSD has widely been used in conventional medicines that possess various pharmacological activities, viz., antioxidant, antimutagenic, antiplatelet, immunomodulatory, antibacterial, antiviral, neuroprotection, and blood circulation improvement [7][8][9][10][11][12]. SSD comprises several bioactive compounds in which flavonoids are predominant, including 3 ′ ,4 ′ ,7-trihydroxyflavone, 3 ′ -hydroxy-8-methoxyvestitol, butin, calycosin, dihydrokaempferol, dihydroquercetin, eriodictyol, liquiritigenin, plathymenin, and prunetin, and many of them exert anticancer properties [11,13,14]. Furthermore, numerous experimental pieces of evidence have been shown that crude extracts of SSD produce a favorable outcome in the management of cancer [15][16][17] and coronary heart diseases [18].…”

Review of Natural Compounds for the Management and Prevention of Lymphoma

“…Spatholobus suberectus Dunn (SSD) regulated the miR-657ATF-2 and induced endoplasmic reticulum (ER) stress related apoptosis along with reactive oxygen species (ROS) generation [11]. Additionally, SSD has been reported regarding its anticancer effect in breast cancer and glioma [11][12][13][14]. To date, Salvia miltiorrhiza (SM) is one of the well-known natural components considered as a cure for various human diseases.…”

Isoliquiritigenin Derivative Regulates miR-374a/BAX Axis to Suppress Triple-Negative Breast Cancer Tumorigenesis and Development

“…Spatholobus suberectus Dunn (S. suberectus), a common Chinese herb used for treating blood-stasis related diseases, exerted potential anticancer effects (Kang et al, 2003;Kim et al, 2018;Lim et al, 2019). Especially, S. suberectus and flavonoids from S. suberectus, displayed a potent inhibitory effect on breast cancer (Peng et al, 2019b). S. suberectus could inhibit breast cancer cells migration through PI3K/ AKT pathway and suppress breast cancer cells proliferation through lactate dehydrogenase (Wang et al, 2013b;Sun et al, 2016).…”