New isatin derivatives

Mesropyan, E. G.; Avetisyan, A. A.

doi:10.1134/s1070428009110013

Cited by 8 publications

(3 citation statements)

References 39 publications

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“…A number of review articles illustrating the chemistry and biological activity of isatins have been published. Reviews that discuss the utility of isatin as a precursor for the synthesis of other heterocyclic compounds are also available [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

3-Hydrazinoindolin-2-one derivatives: Chemical classification and investigation of their targets as anticancer agents

Ibrahim

Abou‐Seri

Abdel‐Aziz

2016

European Journal of Medicinal Chemistry

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Section: Introductionmentioning

confidence: 99%

3-Hydrazinoindolin-2-one derivatives: Chemical classification and investigation of their targets as anticancer agents

Ibrahim

Abou‐Seri

Abdel‐Aziz

2016

European Journal of Medicinal Chemistry

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“…A number of review articles, including a comprehensive survey by da Silva et al [21] describing the synthesis and chemistry of isatin have been published [22][23][24]. Reviews that discuss the utility of isatin as a precursor for the synthesis of other heterocyclic compounds are also available [25][26][27].…”

Section: Fig (1) the Chemical Structures Of Isatin (1) And Indigo (mentioning

confidence: 99%

Recent Highlights in the Development of Isatin-Based Anticancer Agents

Vine¹,

Matesic²,

Locke³

et al. 2013

Advances in Anticancer Agents in Medicinal Chemistry

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Isatin (1H-indole-2,3-dione) and its derivatives are responsible for a broad spectrum of biological activities. Among these the cytotoxic and antineoplastic properties have been the most widely reported. The synthetic versatility of the isatin, due to its privileged scaffold, has led to the generation of a large number of structurally diverse derivatives which include analogues derived from either mono-, di-, and trisubstitution of the aryl ring A, and/or those obtained by derivatisation of the isatin nitrogen and C2/C3 carbonyl moieties. These compounds inhibit cancer cell proliferation and tumour growth via interaction with a variety of intracellular targets such as DNA, telomerase, tubulin, P-glycoprotein, protein kinases and phosphatases. Herein we review recent highlights in the development of isatin-based compounds as anticancer agents with a particular focus on the cytotoxicity and structure activity relationships. Abstract:Isatin (1H-indole-2,3-dione) and its derivatives are responsible for a broad spectrum of biological activities. Among these the cytotoxic and antineoplastic properties have been the most widely reported. The synthetic versatility of the isatin, due to its privileged scaffold, has led to the generation of a large number of structurally diverse derivatives which include analogues derived from either mono-, di-, and tri-substitution of the aryl ring A, and/or those obtained by derivatisation of the isatin nitrogen and C2/C3 carbonyl moieties. These compounds inhibit cancer cell proliferation and tumour growth via interaction with a variety of intracellular targets such as DNA, telomerase, tubulin, Pglycoprotein, protein kinases and phosphatases. Herein we review recent highlights in the development of isatin-based compounds as anticancer agents with a particular focus on the cytotoxicity and structure activity relationships.

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“…Они ингибируют рост опухолей, оказывают противовирусное, противобактериальное, противогрибковое действие, влияют на ЦНС, обладают противотуберкулезной активностью. В связи с этим, получение новых производных изатинов, изучение их свойств, использование в качестве строительных блоков для синтеза других гетероциклических структур является актуальной и перспективной задачей [1,2].…”

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Синтез Новых Производных Изатина, Содержащих 1,2,3-Триазольное Кольцо

Галстян¹,

Еганян²,

Кочикян³

2022

Chemical Journal of Armenia

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Взаимодействием N-пропаргилизатина с бензилазидами в условиях CuAAC (Cu-catalyzed azide-alkyne cycloaddition) клик реакции были получены соответствующие 1,2,3-триазолоизатины с хорошими выходами. На базе последних получены соответствующие тиосемикарбазоны, которые могут являться синтонами для построения новых гетероциклических систем.

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New isatin derivatives

Abstract: The review compiles published data on the synthesis and biological action of new isatin derivatives containing in their composition additional oxygen, nitrogen, or sulfur heterocycles.

Cited by 8 publications

References 39 publications

3-Hydrazinoindolin-2-one derivatives: Chemical classification and investigation of their targets as anticancer agents

3-Hydrazinoindolin-2-one derivatives: Chemical classification and investigation of their targets as anticancer agents

Recent Highlights in the Development of Isatin-Based Anticancer Agents

Синтез Новых Производных Изатина, Содержащих 1,2,3-Триазольное Кольцо

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