New insights on transition metal coordination compounds with biological active azole and nitroimidazole derivatives

Novel Sulfone 2-Aminobenzimidazole Derivatives and Their Coordination Compounds: Contribution of the Ethyl and Phenyl Substituents on Non-Covalent Molecular Interactions; Biological Antiproliferative Activity

“…Anal. calculated for ZnC 22 A solution of the ligand (0.1267 g, 0.5 mmol) and CdCl 2 •2.5H 2 O (0.0572 g, 0.25 mmol) in 15 mL of ethanol was stirred under reflux for 30 min. The reaction mixture was left to stand at room temperature.…”

“…An example of the relevance of the specificity of non-covalent interactions is found with the interaction of coordination compounds with the quadruplex conformation of DNA, found at the telomeres of chromosomes in guanine rich sections, and that has been related to cell aging and apoptosis [16][17][18][19][20] The continuous study of non-covalent interactions has been relevant to the design of biologically active compounds [21]. We have been interested in the design of biologically active ligands and their corresponding transition metal coordination compounds, specifically focused on the influence of non-covalent interactions into their biological properties [22].…”

Silver(i) complexes containing antifungal azoles: significant improvement of the anti-Candida potential of the azole drug after its coordination to the silver(i) ion

“…16–18 It is thus not surprising that research of metal complexes as antifungals is quite popular nowadays. 19,20…”

Anti-toxoplasma activity and DNA-binding of copper(II) and zinc(II) coordination compounds with 5-nitroimidazole-based ligands

“…Due to reported clinical resistance and side effects, the use of 5-nitroimidazoles as ligands to generate coordination compounds has been reported as an alternative for the treatment against parasites and bacteria [ 11 ]. We have been interested in investigating the biological activity of a series of coordination compounds with nitroimidazole derivatives; among them tinidazole complexes were synthesized.…”